Compile Data Set for Download or QSAR
Report error Found 17 Enz. Inhib. hit(s) with all data for entry = 50013742
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50569187(CHEMBL4861646)
Affinity DataKd:  5.95E+3nMAssay Description:Binding affinity to human wild type RIPK1 (M1/K305) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50569187(CHEMBL4861646)
Affinity DataKd:  7.20nMAssay Description:Binding affinity to human wild type RIPK3 (M1/Q307) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 0.580nMAssay Description:Inhibition of PDGFRA (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition measured after 6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50085415(G6416 (GW5074) | 3-(3,5-dibromo-4-hydroxybenzylide...)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of BRAF (unknown origin) in presence of ATP by Lanthascreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
LigandPNGBDBM25045(CHEMBL538346 | mTOR Inhibitor, PI103 | PI-103 | 3-...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human PI3Kalpha using ATP as substrate at 25 uM incubated for 60 mins by ADP-glo based luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM25045(CHEMBL538346 | mTOR Inhibitor, PI103 | PI-103 | 3-...)
Affinity DataIC50: 7.20nMAssay Description:Inhibition of mTOR (unknown origin) using ATP as substrate after 60 mins by Lance ultra assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 43nMAssay Description:Inhibition of CDK4/Cyclin D3 (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM2579(CHEMBL388978 | Staurosporine, 8 | Staurosporin, 4 ...)
Affinity DataIC50: 78nMAssay Description:Inhibition of EGFR (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition measured after 60 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50569187(CHEMBL4861646)
Affinity DataIC50: 152nMAssay Description:Inhibition of PDGFRA (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition measured after 6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetActivin receptor type-1B(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50110205(4-(4-Benzo[1,3]dioxol-5-yl-5-pyridin-2-yl-1H-imida...)
Affinity DataIC50: 158nMAssay Description:Inhibition of human ALK4 using ATP as substrate incubated for 60 mins by ADP-glo based luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50569187(CHEMBL4861646)
Affinity DataIC50: 1.36E+3nMAssay Description:Inhibition of BRAF (unknown origin) in presence of ATP by Lanthascreen TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetActivin receptor type-1B(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50569187(CHEMBL4861646)
Affinity DataIC50: 3.74E+3nMAssay Description:Inhibition of human ALK4 using ATP as substrate incubated for 60 mins by ADP-glo based luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
LigandPNGBDBM50569187(CHEMBL4861646)
Affinity DataIC50: 7.77E+3nMAssay Description:Inhibition of human PI3Kalpha using ATP as substrate at 25 uM incubated for 60 mins by ADP-glo based luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50569187(CHEMBL4861646)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK4/Cyclin D3 (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50569187(CHEMBL4861646)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of mTOR (unknown origin) using ATP as substrate after 60 mins by Lance ultra assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50569187(CHEMBL4861646)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EGFR (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition measured after 60 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50569187(CHEMBL4861646)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO-K1 cells by QPatch - automated patch-clamp technologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed