Compile Data Set for Download or QSAR
Report error Found 8 Enz. Inhib. hit(s) with all data for entry = 50018106
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50404041(CHEMBL5287751)
Affinity DataIC50: 0.583nMAssay Description:Inhibition of full length SHP2 (unknown origin) using DiFMUP as substrate preincubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50087879(NSC-87877 | CHEMBL472004)
Affinity DataIC50: 295nMAssay Description:Inhibition of recombinant GST-tagged full length human SHP2 E76K mutant expressed in Escherichia coli DH5alpha using DiFMUP as substrate incubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50087879(NSC-87877 | CHEMBL472004)
Affinity DataIC50: 318nMAssay Description:Inhibition of recombinant GST/PTP-fused human SHP2 (205 to 593 residues) expressed in Escherichia coli DH5alpha using DiFMUP as substrate incubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50546211(CHEMBL4796034)
Affinity DataIC50: 1.89E+4nMAssay Description:Inhibition of 6His-tagged TEV protease fused human SHP2 (1 to 525 residues) expressed in Escherichia coli BL21 star (DE3) using DiFMUP as substrate p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50546213(CHEMBL4754197)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of 6His-tagged TEV protease fused human SHP2 (1 to 525 residues) expressed in Escherichia coli BL21 star (DE3) using DiFMUP as substrate p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50404071(CHEMBL5268667)
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition of wild type SHP2 PTP domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50546210(CHEMBL1434615)
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of 6His-tagged TEV protease fused human SHP2 (1 to 525 residues) expressed in Escherichia coli BL21 star (DE3) using DiFMUP as substrate p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50404040(CHEMBL5288934)
Affinity DataKi:  730nMAssay Description:Inhibition of SHP2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed