PMID

Data

Article Title

Organization

Discovery and Characterization of the Topical Soft JAK Inhibitor CEE321 for Atopic Dermatitis.

Novartis

Use of a pharmacophore model for the design of EGFR tyrosine kinase inhibitors: isoflavones and 3-phenyl-4(1H)-quinolones.

Novartis

PYRROLE DERIVATIVE OR PHARMACEUTICALLY OR SITOLOGICALLY ACCEPTABLE SALTS THEREOF, AND COMPOSITION FOR PREVENTION, AMELIORATION OR TREATMENT OF GASTROINTESTINAL DISORDERS COMPRISING SAME AS ACTIVE INGREDIENT

Hana Pharm Co.

THIENOPYRROLE COMPOUNDS

Gilead Sciences

Cannabinoid Receptor Modulating Compounds

THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human

SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER

Astrazeneca

Antibiotics for veterinary staphylococcal infections

The George Washington University

METHODS FOR TREATING A PULMONARY DISEASE WITH AN ALK-5 (TGF BETA R1) INHIBITOR

Thirona Bio

Substituted 1,1′-biphenyl compounds, analogues thereof, and methods using same

Arbutus Biopharma

PROTEOLYSIS TARGETING CHIMERAS AND METHODS OF USE THEREOF

University of Maryland, Baltimore

Process route of compound of formula (IV), crystal form and preparation method therefor

Shandong Danhong Pharmaceutical Co.

INDOLINE DERIVATIVES AS DDR1 AND DDR2 INHIBITORS

Chiesi Farmaceutici

HETEROCYCLIC DERIVATIVE INHIBITOR AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

Shanghai Hansoh Biomedical Co.

TETRAHYDROTHIENO PYRIDINE DERIVATIVES AS DDRS INHIBITORS

Chiesi Farmaceutici

Pyrazole-containing macrophage migration inhibitory factor inhibitors

Yale University

KIT KINASE INHIBITORS AND METHODS OF USE THEREOF

Deciphera Pharmaceuticals, LLC

MACROCYCLIC COMPOUNDS AS PROTEASOME INHIBITORS

Cornell University

Pyrazolopyridine compounds and uses thereof

Incyte

MASP INHIBITORY COMPOUNDS AND USES THEREOF

Bayer Aktiengesellschaft

cGAS INHIBITORS

Eli Lilly

Heterocyclic sulfonamide derivative and medicine comprising same

Ea Pharma

ENPP1 inhibitors and their use for the treatment of cancer

The Leland Stanford Junior University

Naphthyridinone compounds as JAK2 V617F inhibitors

Incyte

Imidazole-containing inhibitors of ALK2 kinase

Biocryst Pharmaceuticals

Indoleamine-2,3-dioxygenase inhibitor, preparation method therefor and use thereof

Hinova Pharmaceuticals

Alkyne substituted quinazoline compound and methods of use

Newgen Therapeutics

Cyclic peptide immunomodulators

Bristol-Myers Squibb

Aromatic heterocyclic substituted olefin compound, preparation method for same, pharmaceutical composition of same, and applications thereof

Shanghai Yingli Pharmaceutical

Quinoline analogs as phosphatidylinositol 3-kinase inhibitors

Nanjing Zhengxiang Pharmaceuticals

Sulfonamide-substituted cyanopyrrolidines with activity as DUB inhibitors

Mission Therapeutics

Compounds and methods for treating oxalate-related diseases

Oxalurx

CD73 inhibitors

Oric Pharmaceuticals

Substituted bicyclic pyrimidine-based compounds and compositions and uses thereof

Royal Institution For The Advancement of Learning

Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as JAK inhibitors

Incyte Holdings

Aza-indazole compounds for use in tendon and/or ligament injuries

Novartis

Personal care compositions comprising fatty acid amide derivatives

Conopco

Human plasma kallikrein inhibitors

Biocryst Pharmaceuticals

3-(5-amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof

Novartis

Matriptase inhibitors and uses thereof

SociÉTÉ

MAP kinase modulators and uses thereof

Columbia University

Cycloalkyl-containing apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof

Enanta Pharmaceuticals

SHMT inhibitors

The Trustees of Princeton University

Tricyclic ASK1 inhibitors

Terns

Arf6 inhibitors and methods of synthesis and use thereof

Navigen

WDR5 inhibitors and modulators

Vanderbilt University

FXR (NR1H4) modulating compounds

Gilead Sciences

Carbazole-containing amides, carbamates, and ureas as cryptochrome modulators

Synchronicity Pharma

Antidiabetic bicyclic compounds

Merch Sharp & Dohne Corp. Rahway

Indole derivatives and their use in neurodegenerative diseases

Merck Patent

Somatostatin receptor subtype 4 (SSTR4) agonists

Centrexion Therapeutics

Substituted purine derivative

Sumitomo Dainippon Pharma

Guanidine derivative and medical use thereof

Toray Industries

Bicyclic proline compounds

Genentech

Methods using HDAC11 inhibitors

Forma Therapeutics

Heterocyclylamines as PI3K inhibitors

Incyte Holdings

Substituted nucleoside derivatives useful as anticancer agents

Pfizer

Pyrazolopyrimidine derivatives as BTK inhibitors for the treatment of cancer

Loxo Oncology

Aminobenzisoxazole compounds as agonists of α7-nicotinic acetylcholine receptors

Axovant Sciences

Cyclobutyl-imidazolidinone compounds

Eli Lilly

TYK2 inhibitors, uses, and methods for production thereof

Nimbus Lakshmi

1-alkyl-6-oxo-1,6-dihydropyridin-3-yl compounds and use as SGRM modulators

Astrazeneca

Heterocyclic sulfone RORγ modulators

Bristol-Myers Squibb

Substituted pyridines as inhibitors of human immunodeficiency virus replication

Viiv Healthcare UK (NO.5)

Selective caspase inhibitors and uses thereof

Genesis Technologies

PAR4 agonist peptides

Bristol-Myers Squibb

Pyrimidines as sodium channel blockers

TBA

Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors

Incyte

Cyclopropylamines as LSD1 inhibitors

Incyte

Kinase inhibitors

University of California

Protein kinase B inhibitors

Astrazeneca

Disubstituted oxazolidin-2-ones 5-hydroxytryptamine receptor 2B activity modulators

Temple University

Sulfonamides as TRPM8 modulators

Janssen Pharmaceutica

2,4-diamino-6,7-dihydro-5H-pyrrolo[2,3]pyrimidine derivatives as FAK/Pyk2 inhibitors

Centaurus Biopharma

Pyrazole carboxamides as Janus kinase inhibitors

Merck Sharp & Dohme

Arylated camphenes, processes for their preparation and uses thereof

Hebrew University of Jerusalem

Synthesis and biological evaluation of 2,5-disubstituted 1,3,4-oxadiazole derivatives with both COX and LOX inhibitory activity.

Jamia Hamdard University

Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use

Merck Sharp & Dohme

Pharmaceutical uses of 6-amino quinazoline or 3-cyano quinoline derivatives

Jiangsu Hengrui Medicine

Rational design of broad spectrum antibacterial activity based on a clinically relevant enoyl-acyl carrier protein (ACP) reductase inhibitor.

University of Wuerzburg

Tropomyosin-related kinase inhibitors

Pfizer

Design, Synthesis, and Experimental Validation of Peptide Ligands Targeting Mycobacterium tuberculosis s Factors.

Indian Institute of Science

Facile dimethyl amino group triggered cyclic sulfonamides synthesis and evaluation as alkaline phosphatase inhibitors.

University of Karachi

HDAC inhibitors and therapeutic methods using the same

University of Illinois

Bicyclic sulfonamide compounds as sodium channel inhibitors

Amgen

Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.

Technical University of Munich

Lactam derivatives useful as orexin receptor antagonists

Actelion Pharmaceuticals

1,4 oxazines as BACE1 and/or BACE2 inhibitors

Siena Biotech

Compounds that are ERK inhibitors

Merck Sharp & Dohme

Metronidazole containing pyrazole derivatives potently inhibit tyrosyl-tRNA synthetase: design, synthesis, and biological evaluation.

Nanjing University

Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase.

Universitätsklinikum Frankfurt

N-[4-(1H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]sulfonamides as pharmaceuticals

Sanofi

Aggrecanase inhibitors

Eli Lilly

3-aryl-5-substituted-isoquinolin-1-one compounds and their therapeutic use

Institute of Cancer Research

Inhibitors of glutaminyl cyclase

Probiodrug

Azetidine compounds, compositions and methods of use

Hoffmann-La Roche

Hybrid benzothiazole analogs as antiurease agent: Synthesis and molecular docking studies.

Universiti Teknologi Mara (Uitm), Puncak Alam Campus

ß-Hydroxyacyl-acyl Carrier Protein Dehydratase (FabZ) from Francisella tularensis and Yersinia pestis: Structure Determination, Enzymatic Characterization, and Cross-Inhibition Studies.

Brookhaven National Laboratory

Mechanism of MenE inhibition by acyl-adenylate analogues and discovery of novel antibacterial agents.

Argonne National Laboratory

Saccharide conjugates

Curators of The University of Missouri

Substituted phenylureas and phenylamides as vanilloid receptor ligands

Gruenenthal

Plasminogen activator inhibitor-1 inhibitors and methods of use thereof to modulate lipid metabolism

University of Michigan

Dihydropyrimidine based hydrazine dihydrochloride derivatives as potent urease inhibitors.

University of Karachi

Inhibition of guinea pig aldehyde oxidase activity by different flavonoid compounds: An in vitro study.

Kermanshah University of Medical Sciences

Synthesis, cholinesterase inhibition and molecular modelling studies of coumarin linked thiourea derivatives.

Quaid-I-Azam University

Synthesis and biological evaluation of kojic acid derivatives containing 1,2,4-triazole as potent tyrosinase inhibitors.

Hunan University of Science and Technology

Pyridine compounds and the users thereof

Purdue Pharma

Biphenyl derivatives useful as glucagon receptor antagonists

Janssen Pharmaceutica

Diphenylmethane derivatives as SGLT2 inhibitors

Green Cross

Neuroprotective and neuro-restorative iron chelators and monoamine oxidase inhibitors and uses thereof

TBA

Substituted indazole derivatives active as kinase inhibitors

Nerviano Medical Sciences

Prolylcarboxypeptidase inhibitors

Merck Sharp & Dohme

Exploring the Role of Residue 228 in Substrate and Inhibitor Recognition by VIM Metallo-ß-lactamases.

Louis Stokes Cleveland Veterans Affairs Medical Center

Biochemical and structural analysis of an Eis family aminoglycoside acetyltransferase from bacillus anthracis.

University of Kentucky

Biochemical and structural analysis of inhibitors targeting the ADC-7 cephalosporinase of Acinetobacter baumannii.

Grand Valley State University

Substituted pyrimido[1,2-b]indazoles and their use as modulators of the Pi3K/Akt pathway

Bayer Intellectual Property

Salicylanilide diethyl phosphates as cholinesterases inhibitors.

Charles University In Prague

Inhibitors of glutaminyl cyclase

Probiodrug

Heteroaryloxycarbocyclyl compounds as PDE10 inhibitors

Amgen

Inhibitors of protein kinases

Portola Pharmaceuticals

Antibacterial compounds

Institut Curie

Nicotinic acetylcholine receptor sub-type selective amides of diazabicycloalkanes

Targacept

Benzofurane-piperidine compounds

Hoffmann-La Roche

Substituted 2-(chroman-6-yloxy)-thiazoles and their use as pharmaceuticals

Sanofi

Substituted pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors

Nerviano Medical Sciences

Substituted oxazolidinones and their use in the field of blood coagulation

Bayer Intellectual Property

Inhibitors of histone deacetylase and prodrugs thereof

Methylgene

Amino-pyridine-containing spleen tyrosine kinase (SYK) inhibitors

Merck Sharp & Dohme

Tricyclic imidazole compounds as PDE10 inhibitors

H. Lundbeck

Design and synthesis of paracaseolide A analogues as selective protein tyrosine phosphatase 1B inhibitors.

Lanzhou University

A facile one-pot synthesis of 2-arylamino-5-aryloxylalkyl-1,3,4-oxadiazoles and their urease inhibition studies.

Mirpur University of Science and Technology (Must)

4-methylpyridopyrimidinone compounds

Pfizer

Triazolopyridine compounds as PIM kinase inhibitors

Array Biopharma

Fluorescence Linked Enzyme Chemoproteomic Strategy for Discovery of a Potent and Selective DAPK1 and ZIPK Inhibitor.

Duke University Medical Center

Substituted indanes, method for the production thereof, and use thereof as drugs

Sanofi

Salvinorin derivatives and uses thereof

The Mclean Hospital

Substituted imidazopyr- and imidazotri-azines

Osi Pharmaceuticals

Compounds useful as inhibitors of atr kinase

Vertex Pharmaceuticals

Characterization of the CHK1 allosteric inhibitor binding site.

Pfizer

Oxygenation of monoenoic fatty acids by CYP175A1, an orphan cytochrome P450 from Thermus thermophilus HB27.

Tata Institute of Fundamental Research

Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function.

Astex Pharmaceuticals

Small neutralizing molecules to inhibit actions of the chemokine CXCL12.

UniversitÉ

Probing the active site of the deoxynucleotide N-hydrolase Rcl encoded by the rat gene c6orf108.

Institut Pasteur

New tryptophanase inhibitors: towards prevention of bacterial biofilm formation.

Ben-Gurion University of The Negev

Preclinical profile of ciclesonide, a novel corticosteroid for the treatment of asthma.

Imperial College

N,N'-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) and structurally related compounds: novel allosteric enhancers of gamma-aminobutyric acidB receptor function.

Novartis Pharma

Binding and GTPgammaS autoradiographic analysis of preproorphanin precursor peptide products at the ORL1 and opioid receptors.

University of Michigan

The novel melatonin agonist agomelatine (S20098) is an antagonist at 5-hydroxytryptamine2C receptors, blockade of which enhances the activity of frontocortical dopaminergic and adrenergic pathways.

Institut De Recherches Servier

Pharmacological characterization of ZD6021: a novel, orally active antagonist of the tachykinin receptors.

Astrazeneca Pharmaceuticals

Rabbit alpha2-adrenoceptors: both platelets and adipocytes have alpha2A-pharmacology.

Glaxosmithkline

Receptor binding, behavioral, and electrophysiological profiles of nonpeptide corticotropin-releasing factor subtype 1 receptor antagonists CRA1000 and CRA1001.

Taisho Pharmaceutical

Cloning and expression of human 5-HT4S receptors. Effect of receptor density on their coupling to adenylyl cyclase.

Cnrs Upr 9023

Cloning, expression and pharmacology of a truncated splice variant of the human 5-HT7 receptor (h5-HT7b).

Roche Bioscience

Identification and characterization of new inhibitors of fungal homoserine kinase.

Mcmaster University

SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist.

Smithkline Beecham Pharmaceuticals

Characterisation of the melanocortin 4 receptor by radioligand binding.

Uppsala University

Radioreceptor binding profile of the atypical antipsychotic olanzapine.

Eli Lilly

Cannabinoid structure-activity relationships: correlation of receptor binding and in vivo activities.

Virginia Commonwealth University

Inhibition of Golgi mannosidase II with mannostatin A analogues: synthesis, biological evaluation, and structure-activity relationship studies.

University of Georgia

GR113808: a novel, selective antagonist with high affinity at the 5-HT4 receptor.

Glaxo Group Research

Pharmacological profile of (R)-1-[2,3-dihydro-1-(2'-methylphenacyl)-2-oxo- 5-phenyl-1H-1,4-benzodiazepin-3-yl]-3-(3-methylphenyl)urea (YM022), a new potent and selective gastrin/cholecystokinin-B receptor antagonist, in vitro and in vivo.

Yamanouchi Pharmaceutical

Structural requirements for the binding of the pituitary adenylate-cyclase-activating peptide to receptors and adenylate-cyclase activation in pancreatic and neuronal membranes.

UniversitÉ

Pharmacological characterization of a new class of nonpeptide neurokinin A antagonists that demonstrate species selectivity.

Zeneca Pharmaceuticals

Cholecystokinin receptors: biochemical demonstration and autoradiographical localization in rat brain and pancreas using [3H] cholecystokinin8 as radioligand.

F. Hoffmann-La Roche

Sertraline, 1S,4S-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine, a new uptake inhibitor with selectivity for serotonin.

Pfizer

Muscarinic cholinergic binding in rat brain.

TBA

Characterization of high affinity [3H]pirenzepine and (-)-[3H] quinuclidinyl benzilate binding to muscarinic cholinergic receptors in rabbit peripheral lung.

University of Arizona

Characterization of D1 dopamine receptors in the bovine pineal gland with [3H]SCH 23390.

University of Nebraska

Characterization of two novel cholecystokinin tetrapeptide (30-33) analogues, A-71623 and A-70874, that exhibit high potency and selectivity for cholecystokinin-A receptors.

Abbott Laboratories

Peripheral-type benzodiazepine receptors in human cerebral cortex, kidney, and colon.

Technion-Israel Institute of Technology

The mouse 5HT5 receptor reveals a remarkable heterogeneity within the 5HT1D receptor family.

Cnrs

Virtual screening for potential inhibitors of homology modeled Leptospira interrogans MurD ligase.

Svims University

Novel protein kinase D inhibitors cause potent arrest in prostate cancer cell growth and motility.

University of Pittsburgh

Characterization of a novel 5-HT4 receptor antagonist of the azabicycloalkyl benzimidazolone class: DAU 6285.

Centre De Pharmacologie-Endocrinologie (Montpellier, France)

Molecular cloning and functional characterization of a human 5-HT1B serotonin receptor: a homologue of the rat 5-HT1B receptor with 5-HT1D-like pharmacological specificity.

Veterans Affairs Medical Center

Functional studies of Plasmodium falciparum dipeptidyl aminopeptidase I using small molecule inhibitors and active site probes.

Stanford School of Medicine

Discovery of dual inhibitors of the immune cell PI3Ks p110delta and p110gamma: a prototype for new anti-inflammatory drugs.

University of California San Francisco

Fumagillin and fumarranol interact with P. falciparum methionine aminopeptidase 2 and inhibit malaria parasite growth in vitro and in vivo.

Johns Hopkins School of Medicine

Synthetic estrogen derivatives demonstrate the functionality of intracellular GPR30.

University of New Mexico Health Sciences Center

Discovery of potent, selective, and orally bioavailable oxadiazole-based dipeptidyl peptidase IV inhibitors.

Merck Research Laboratories

Synthesis and pharmacological evaluation of huprine-tacrine heterodimers: subnanomolar dual binding site acetylcholinesterase inhibitors.

Universitat De Barcelona

Modulation of global low-frequency motions underlies allosteric regulation: demonstration in CRP/FNR family transcription factors.

Durham University

Enthalpy versus entropy-driven binding of bisphosphonates to farnesyl diphosphate synthase.

University of Illinois At Urbana-Champaign