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Proof of concept study for designed multiple ligands targeting the dopamine D2, serotonin 5-HT2A, and muscarinic M1 acetylcholine receptors.

Monash University (Parkville Campus)

Feeling Nature's PAINS: Natural Products, Natural Product Drugs, and Pan Assay Interference Compounds (PAINS).

Monash University (Parkville Campus)

From Sphingosine Kinase to Dihydroceramide Desaturase: A Structure-Activity Relationship (SAR) Study of the Enzyme Inhibitory and Anticancer Activity of 4-((4-(4-Chlorophenyl)thiazol-2-yl)amino)phenol (SKI-II).

Monash University (Parkville Campus)

Synthesis and pharmacological evaluation of dual acting ligands targeting the adenosine A2A and dopamine D2 receptors for the potential treatment of Parkinson's disease.

Monash University (Parkville Campus)

Class II but Not Second Class-Prospects for the Development of Class II PI3K Inhibitors.

Monash University (Parkville Campus)

Dicarba analogues ofa-conotoxin RgIA. Structure, stability, and activity at potential pain targets.

Monash University (Parkville Campus)

Synthesis and pharmacological evaluation of analogues of benzyl quinolone carboxylic acid (BQCA) designed to bind irreversibly to an allosteric site of the M1 muscarinic acetylcholine receptor.

Monash University (Parkville Campus)

A structure-activity analysis of biased agonism at the dopamine D2 receptor.

Monash University (Parkville Campus)

L-Aminoacyl-triazine derivatives are isoform-selective PI3Kβ inhibitors that target non-conserved Asp862 of PI3Kβ

Monash University (Parkville Campus)

Structure-activity relationship exploration of Kv1.3 blockers based on diphenoxylate.

Monash University (Parkville Campus)

Homobivalent ligands of the atypical antipsychotic clozapine: design, synthesis, and pharmacological evaluation.

Monash University (Parkville Campus)

Synthesis and SAR study of 4-arylpiperidines and 4-aryl-1,2,3,6-tetrahydropyridines as 5-HT2C agonists.

Monash University (Parkville Campus)

Characterization of the drug binding specificity of rat liver fatty acid binding protein.

Monash University (Parkville Campus)

N6-substituted C5'-modified adenosines as A1 adenosine receptor agonists.

Monash University (Parkville Campus)

Structure-activity relationships of adenosines with heterocyclic N6-substituents.

Monash University (Parkville Campus)

The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases.

Monash University (Parkville Campus)

Synthesis of novel sialylmimetics as biological probes.

Monash University (Parkville Campus)

Thiophene inhibitors of PDE4: crystal structures show a second binding mode at the catalytic domain of PDE4D2.

Monash University (Parkville Campus)

The design, synthesis and biological evaluation of novel URB602 analogues as potential monoacylglycerol lipase inhibitors.

Monash University (Parkville Campus)

Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with antiparasitic activity.

Monash University (Parkville Campus)

Structure-based optimization and biological evaluation of human 20a-hydroxysteroid dehydrogenase (AKR1C1) salicylic acid-based inhibitors.

Monash University (Parkville Campus)

Structure of aldehyde reductase in ternary complex with a 5-arylidene-2,4-thiazolidinedione aldose reductase inhibitor.

Monash University (Parkville Campus)

3- and 6-Substituted 2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridines as A1 adenosine receptor allosteric modulators and antagonists.

Monash University (Parkville Campus)

Structure-guided design, synthesis, and evaluation of salicylic acid-based inhibitors targeting a selectivity pocket in the active site of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1).

Monash University (Parkville Campus)

Correlation of binding constants and molecular modelling of inhibitors in the active sites of aldose reductase and aldehyde reductase.

Monash University (Parkville Campus)

Synthesis and cannabinoid activity of 1-substituted-indole-3-oxadiazole derivatives: novel agonists for the CB1 receptor.

Monash University (Parkville Campus)

Dual acting antioxidant A1 adenosine receptor agonists.

Monash University (Parkville Campus)

Rapid Elaboration of Fragments into Leads Applied to Bromodomain-3 Extra-Terminal Domain.

Monash University (Parkville Campus)

Targeting Melanocortin Receptors Using S

Monash University (Parkville Campus)

Structure of aldehyde reductase holoenzyme in complex with the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity.

Monash University (Parkville Campus)

The Design, Synthesis, and Evaluation of Novel 9-Arylxanthenedione-Based Allosteric Modulators for the δ

Monash University (Parkville Campus)

High-resolution structures of human aldose reductase holoenzyme in complex with stereoisomers of the potent inhibitor Fidarestat: stereospecific interaction between the enzyme and a cyclic imide type inhibitor.

Monash University (Parkville Campus)

Synthesis and evaluation of pyridine-derived bedaquiline analogues containing modifications at the A-ring subunit.

Monash University (Parkville Campus)

New irreversible adenosine A(1) antagonists based on FSCPX.

Monash University (Parkville Campus)

Substituted 1-methyl-4-phenylpyrrolidin-2-ones - Fragment-based design of N-methylpyrrolidone-derived bromodomain inhibitors.

Monash University (Parkville Campus)

Modelling studies of the active site of human sorbitol dehydrogenase: an approach to structure-based inhibitor design of the enzyme.

Monash University (Parkville Campus)

Rapid Elaboration of Fragments into Leads by X-ray Crystallographic Screening of Parallel Chemical Libraries (REFiL

Monash University (Parkville Campus)

Optically Pure, Structural, and Fluorescent Analogues of a Dimeric Y4 Receptor Agonist Derived by an Olefin Metathesis Approach.

Monash University (Parkville Campus)

Heterodimeric Analogues of the Potent Y1R Antagonist 1229U91, Lacking One of the Pharmacophoric C-Terminal Structures, Retain Potent Y1R Affinity and Show Improved Selectivity over Y4R.

Monash University (Parkville Campus)

Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents.

Monash University (Parkville Campus)

Synthesis and elaboration of N-methylpyrrolidone as an acetamide fragment substitute in bromodomain inhibition.

Monash University (Parkville Campus)

Novel adenosine A(2A) receptor ligands: a synthetic, functional and computational investigation of selected literature adenosine A(2A) receptor antagonists for extending into extracellular space.

Monash University (Parkville Campus)

Probing the inhibitor selectivity pocket of human 20α-hydroxysteroid dehydrogenase (AKR1C1) with X-ray crystallography and site-directed mutagenesis.

Monash University (Parkville Campus)

Antiviral agents 2. Synthesis of trimeric naphthoquinone analogues of conocurvone and their antiviral evaluation against HIV.

Monash University (Parkville Campus)

Synthesis and serotonergic activity of substituted 2, N-benzylcarboxamido-5-(2-ethyl-1-dioxoimidazolidinyl)-N, N-dimethyltryptamine derivatives: novel antagonists for the vascular 5-HT(1B)-like receptor.

Monash University (Parkville Campus)

Synthesis and Pharmacological Evaluation of Heterocyclic Carboxamides: Positive Allosteric Modulators of the M

Monash University (Parkville Campus)