52 articles for thisTarget
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Syntheses and evaluation of pyrido[2,3-dlpyrimidine-2,4-diones as PDE 4 inhibitors.
Korea Institute of Science and Technology
Discovery of benzimidazole derivatives as modulators of mitochondrial function: A potential treatment for Alzheimer's disease.
Korea Institute of Science and Technology
Synthesis of a series of unsaturated ketone derivatives as selective and reversible monoamine oxidase inhibitors.
Korea Institute of Science and Technology
Discovery and biological evaluation of tetrahydrothieno[2,3-c]pyridine derivatives as selective metabotropic glutamate receptor 1 antagonists for the potential treatment of neuropathic pain.
Korea Institute of Science and Technology
Synthesis and biological evaluation of isoxazoline derivatives as potent M1 muscarinic acetylcholine receptor agonists.
Korea Institute of Science and Technology
Resistance by allostery: a novel perspective for eg5-targeted drug design.
Korea Institute of Science and Technology
Novel pyrimidoazepine analogs as serotonin 5-HT(2A) and 5-HT(2C) receptor ligands for the treatment of obesity.
Korea Institute of Science and Technology
Synthesis and biological evaluation of 1-(2-hydroxy-3-phenyloxypropyl)piperazine derivatives as T-type calcium channel blockers.
Korea Institute of Science and Technology
Towards predictive inhibitor design for the EGFR autophosphorylation activity.
Korea Institute of Science and Technology
Synthesis and structure-activity relationships of tri-substituted thiazoles as RAGE antagonists for the treatment of Alzheimer's disease.
Korea Institute of Science and Technology
Exploration of novel 3-substituted azetidine derivatives as triple reuptake inhibitors.
Korea Institute of Science and Technology
Total synthesis and dual PPARa/¿ agonist effects of amorphastilbol and its synthetic derivatives.
Korea Institute of Science and Technology
Receptor-ligand interaction-based virtual screening for novel Eg5/kinesin spindle protein inhibitors.
Korea Institute of Science and Technology
Synthesis and pharmacological evaluation of 3-aryl-3-azolylpropan-1-amines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors.
Korea Institute of Science and Technology
Novel GSK-3beta inhibitors from sequential virtual screening.
Korea Institute of Science and Technology
5-HT2c receptor selectivity and structure-activity relationship of N-methyl-N-(1-methylpiperidin-4-yl)benzenesulfonamide analogs.
Korea Institute of Science and Technology
Synthesis and biological evaluation of 4-piperidinecarboxylate and 4-piperidinecyanide derivatives for T-type calcium channel blockers.
Korea Institute of Science and Technology
Inhibition of a prolyl hydroxylase domain (PHD) by substrate analog peptides.
Korea Institute of Science and Technology
Discovery of piperidinyl aminopyrimidine derivatives as IKK-2 inhibitors.
Korea Institute of Science and Technology
Computational approach to the identification of novel Aurora-A inhibitors.
Korea Institute of Science and Technology
Design, synthesis, broad-spectrum antiproliferative activity, and kinase inhibitory effect of triarylpyrazole derivatives possessing arylamides or arylureas moieties.
Korea Institute of Science and Technology
Identification of (-)-Epigallocateshin gallate derivatives promoting innate immune activation via 2',3'-cyclic GMP-AMP-stimulator of interferon genes pathway.
Korea Institute of Science and Technology
Discovery of 3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one and 3,4-dihydropyrido[2,3-d]pyrimidin-2(1H)-one derivatives as novel ENPP1 inhibitors.
Korea Institute of Science and Technology
Discovery of G Protein-Biased Ligands against 5-HT
Korea Institute of Science and Technology
Discovery of first-in-class imidazothiazole-based potent and selective ErbB4 (HER4) kinase inhibitors.
Korea Institute of Science and Technology
Discovery of G Protein-Biased Antagonists against 5-HT
Korea Institute of Science and Technology
Novel 5,6-disubstituted pyrrolo[2,3-d]pyrimidine derivatives as broad spectrum antiproliferative agents: Synthesis, cell based assays, kinase profile and molecular docking study.
Korea Institute of Science and Technology
Evaluation of anti-depressant effects of phthalazinone-based triple-acting small molecules against 5-HT
Korea Institute of Science and Technology
Chemical Control of Mammalian Circadian Behavior through Dual Inhibition of Casein Kinase Iα and δ.
Korea Institute of Science and Technology
Structural hybridization of pyrrolidine-based T-type calcium channel inhibitors and exploration of their analgesic effects in a neuropathic pain model.
Korea Institute of Science and Technology
Oxazolopyridines and thiazolopyridines as monoamine oxidase B inhibitors for the treatment of Parkinson's disease.
Korea Institute of Science and Technology
Therapeutic and pharmacokinetic characterizations of an anti-amyloidogenic bis-styrylbenzene derivative for Alzheimer's disease treatment.
Korea Institute of Science and Technology
Small molecules that protect against β-amyloid-induced cytotoxicity by inhibiting aggregation of β-amyloid.
Korea Institute of Science and Technology
Inhibition of VEGF transcription through blockade of the hypoxia inducible factor-1α-p300 interaction by a small molecule.
Korea Institute of Science and Technology
Discovery and initial SAR of pyrimidin-4-yl-1H-imidazole derivatives with antiproliferative activity against melanoma cell lines.
Korea Institute of Science and Technology
Vanillic acid glycoside and quinic acid derivatives from Gardeniae Fructus.
Korea Institute of Science and Technology
3D-QSAR models on clinically relevant K103N mutant HIV-1 reverse transcriptase obtained from two strategic considerations.
Korea Institute of Science and Technology
Bis-styrylpyridine and bis-styrylbenzene derivatives as inhibitors for Abeta fibril formation.
Korea Institute of Science and Technology
Identification of crizotinib derivatives as potent SHIP2 inhibitors for the treatment of Alzheimer's disease.
Korea Institute of Science and Technology
Discovery of β-Arrestin Biased Ligands of 5-HT
Korea Institute of Science and Technology
Phenyl-3,4-dihydroisoquinolin-2(1h)-yl-ethan-1-one derivatives as dopamine d1receptor positive allosteric modulators
Eli Lilly
Substituted carboxamides as inhibitors of WDR5 protein-protein binding
Propellon Therapeutics
4-substituted-cyclohexylamino-4-piperidinyl-acetamide antagonists of CCR2
Janssen Pharmaceutica
Evaluation of Coumarin and Neoflavone Derivatives as HCV NS5B Polymerase Inhibitors.
Umdnj-New Jersey Medical School
Unprecedented selectivity and structural determinants of a new class of protein kinase CK2 inhibitors in clinical trials for the treatment of cancer.
Venetian Institute of Molecular Medicine
Characterization of [(3)H]Quisqualate binding to recombinant rat metabotropic glutamate 1a and 5a receptors and to rat and human brain sections.
F. Hoffmann-La Roche