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Structure-activity relationship studies on 1-(2-oxopropyl)indole-5-carboxylic acids acting as inhibitors of cytosolic phospholipase A

University of M£Nster

Design, synthesis, and biological evaluation of 3-(1-Aryl-1H-indol-5-yl)propanoic acids as new indole-based cytosolic phospholipase A2a inhibitors.

Asubio Pharma

Inhibition of group IVA cytosolic phospholipase A2 by thiazolyl ketones in vitro, ex vivo, and in vivo.

University of Athens

1-(5-Carboxyindol-1-yl)propan-2-ones as inhibitors of human cytosolic phospholipase A2alpha: synthesis and properties of bioisosteric benzimidazole, benzotriazole and indazole analogues.

University of M£Nster

1-(2-Carboxyindol-5-yloxy)propan-2-ones as inhibitors of human cytosolic phospholipase A2alpha: synthesis, biological activity, metabolic stability, and solubility.

University of M£Nster

1-Indol-1-yl-propan-2-ones and related heterocyclic compounds as dual inhibitors of cytosolic phospholipase A(2)alpha and fatty acid amide hydrolase.

University of M£Nster

Reactions of functionalized sulfonamides: application to lowering the lipophilicity of cytosolic phospholipase A2alpha inhibitors.

Wyeth Research

 

Dicarboxylic acid inhibitors of phospholipase A₂

TBA

Inhibitory effect of synthetic C-C biflavones on various phospholipase A(2)s activity.

Yeungnam University

Synthesis, activity and metabolic stability of propan-2-one substituted tetrazolylalkanoic acids as dual inhibitors of cytosolic phospholipase A

University of Muenster

1-(5-Carboxy- and 5-carbamoylindol-1-yl)propan-2-ones as inhibitors of human cytosolic phospholipase A2alpha: bioisosteric replacement of the carboxylic acid and carboxamide moiety.

University of MüNster

Discovery of Ecopladib, an indole inhibitor of cytosolic phospholipase A2alpha.

Wyeth Research

Design and synthesis of 1-indol-1-yl-propan-2-ones as inhibitors of human cytosolic phospholipase A2alpha.

University of MüNster

1,2,4-Oxadiazolidin-3,5-diones and 1,3,5-triazin-2,4,6-triones as cytosolic phospholipase A2alpha inhibitors.

Wyeth Research

Inhibition of cytosolic phospholipase A2alpha: hit to lead optimization.

Wyeth Research

Structure-activity relationships of indole cytosolic phospholipase A(2)alpha inhibitors: substrate mimetics.

Wyeth Research

Pyrrolidine inhibitors of human cytosolic phospholipase A(2).

Shionogi

Substrate-Specific Inhibition Constants for Phospholipase A

University of California

β-Lactones: A Novel Class of Ca

National and Kapodistrian University of Athens

Carbamate and urea inhibitors of 11β-hydroxysteroid dehydrogenase 1

Vitae Pharmaceuticals

Structural Basis of Analog Specificity in PKG I and II.

Baylor College of Medicine