PMID

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Development of a potent 2-oxoamide inhibitor of secreted phospholipase A2 guided by molecular docking calculations and molecular dynamics simulations.

National and Kapodistrian University of Athens

Identification of inhibitors against interaction between pro-inflammatory sPLA2-IIA protein and integrinavß3.

University of California

Optimization of 5-hydroxytryptamines as dual function inhibitors targeting phospholipase A2 and leukotriene A4 hydrolase.

Peking University

A new cacospongionolide inhibitor of human secretory phospholipase A2 from the Tyrrhenian sponge Fasciospongia cavernosa and absolute configuration of cacospongionolides.

Istituto Per La Chimica Di Molecole Di Interesse Biologico Cnr

Synthesis and comparison of the antiinflammatory activity of manoalide and cacospongionolide B analogues.

University of Salerno

Synthesis and phospholipase A2 inhibitory activity of thielocin B3 derivatives.

Shionogi

Quinoline-4-methyl esters as human nonpancreatic secretory phospholipase A2 inhibitors.

Peking University

Inhibition of secreted phospholipases A2 by 2-oxoamides based ona-amino acids: Synthesis, in vitro evaluation and molecular docking calculations.

University of Athens

Design of new potent and selective secretory phospholipase A(2) inhibitors. 6-Synthesis, structure-activity relationships and molecular modelling of 1-substituted-4-[4,5-dihydro-1,2,4-(4H)-oxadiazol-5-one-3-yl(methyl)]-functionalized aryl piperazin/one/dione derivatives.

Paris Diderot University

 

A simple synthesis of biaryl phospholipase A₂ inhibitors: Probing hydrophobic effects

TBA

 

Analogs of the marine natural product scalaradial lacking the α,β-unsaturated aldehyde: effects on human synovial fluid phospholipase A₂ and macrophage lipid mediator production

TBA

 

Vinylogous hydroxamic acids: 5-lipoxygenase inhibitors

TBA

Discovery of multitarget inhibitors by combining molecular docking with common pharmacophore matching.

Peking University

Simplified YM-26734 inhibitors of secreted phospholipase A2 group IIA.

University of Washington

Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2.

University of Washington

New sesquiterpene derivatives from the sponge Dysidea species with a selective inhibitor profile against human phospholipase A2 and other leukocyte functions.

Università

Inhibition of secreted phospholipase A2. 4-glycerol derivatives of 4,5-dihydro-3-(4-tetradecyloxybenzyl)-1,2,4-4H-oxadiazol-5-one with broad activities.

Université

Drug-like Antagonists of P2Y Receptors-From Lead Identification to Drug Development.

University of Nottingham

Insights into the medicinal chemistry of heterocycles integrated with a pyrazolo[1,5-

Prince Sattam Bin Abdulaziz University

Recent advancements in the development of heterocyclic anti-inflammatory agents.

Isf College of Pharmacy

The first potent inhibitor of mammalian group X secreted phospholipase A2: elucidation of sites for enhanced binding.

University of Washington

Synthesis of phospholipase A2 inhibitory biflavonoids.

Kangwon National University

The Alpha Keto Amide Moiety as a Privileged Motif in Medicinal Chemistry: Current Insights and Emerging Opportunities.

Niddk

Functionalized quinoxalinones as privileged structures with broad-ranging pharmacological activities.

Central South University

Carbocyclic[g]indole inhibitors of human nonpancreatic s-PLA2.

Eli Lilly

Novel 3-dodecanoylindole-2-carboxylic acid inhibitors of cytosolic phospholipase A(2).

University of MüNster

Discovery of AZD2716: A Novel Secreted Phospholipase A

Astrazeneca

Synthesis and enzyme inhibitory activities of a series of lipidic diamine and aminoalcohol derivatives on cytosolic and secretory phospholipases A2.

Univ. De Valencia

Synthesis and PLA2-inhibitory properties of 2(R)-acetamido-alkylphosphomethanols with a variable aggregate anchor.

Tumor Biology Center

Design and synthesis of new secretory phospholipase A2 inhibitor of a phospholipid analog.

Kwansei Gakuin University

Indole inhibitors of human nonpancreatic secretory phospholipase A2. 1. Indole-3-acetamides.

Eli Lilly

Indole inhibitors of human nonpancreatic secretory phospholipase A2. 3. Indole-3-glyoxamides.

Eli Lilly

Indole inhibitors of human nonpancreatic secretory phospholipase A2. 2. Indole-3-acetamides with additional functionality.

Eli Lilly

N-(carboxymethyl)-N-[3,5-bis(decyloxy)-phenyl]glycine (Ro 23-9358): a potent inhibitor of secretory phospholipases A2 with antiinflammatory activity.

Roche Research Center

Discovery of new non-phospholipid inhibitors of the secretory phospholipases A2.

Fisons

Design of Selective sPLA

Astrazeneca

Discovery of a Series of Indole-2 Carboxamides as Selective Secreted Phospholipase A

Astrazeneca

2-pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors

Tiumbio

Design, synthesis, and 3D QSAR of novel potent and selective aromatase inhibitors.

University of Bari