PMID

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Article Title

Organization

Identification of Potential Off-target Toxicity Liabilities of Catechol-O-methyltransferase Inhibitors by Differential Competition Capture Compound Mass Spectrometry.

Caprotec Bioanalytics

Synthesis and optimization of N-heterocyclic pyridinones as catechol-O-methyltransferase (COMT) inhibitors.

Merck

Arylpiperidines as a new class of oxidosqualene cyclase inhibitors.

Ludwig-Maximilians University

Aminopropylindenes derived from Grundmann's ketone as a novel chemotype of oxidosqualene cyclase inhibitors.

Ludwig-Maximilians-Universit£T M£Nchen

Influence of conformation on GRIND-based three-dimensional quantitative structure-activity relationship (3D-QSAR).

University of Turin

GRIND-based 3D-QSAR to predict inhibitory activity for similar enzymes, OSC and SHC.

Casmedchem Laboratory

Cytotoxic effects of combination of oxidosqualene cyclase inhibitors with atorvastatin in human cancer cells.

Centre Hospitalier Universitaire Vaudois (Chuv) and University of Lausanne (Unil

The biology and chemistry of hyperlipidemia.

Sinhgad College of Pharmacy

Design, synthesis, and biological evaluation of new (2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-ol ethers as inhibitors of human and Trypanosoma cruzi oxidosqualene cyclase.

University of Eastern Piedmont

Synthesis and structure-activity studies of novel orally active non-terpenoic 2,3-oxidosqualene cyclase inhibitors.

F. Hoffmann-La Roche

Inhibitors of human 2,3-oxidosqualene cyclase (OSC) discovered by virtual screening.

Institute of Microbial Chemistry

Novel pyrrole- and 1,2,3-triazole-based 2,3-oxidosqualene cyclase inhibitors.

Institute of Microbial Chemistry

 

Potency and inactivation rates of analogues of an irreversible inhibitor of vertebrate oxidosqualene cyclase

TBA

 

Inhibition of oxidosqualene cyclase by substituted quinolizidines

TBA

 

Inhibition of 2,3-oxidosqualene cyclase by N-alkylpiperidines

TBA

 

2,3:18,19-dioxidosqualene: synthesis and activity as a potent inhibitor of 2,3-oxidosqualene-lanosterol cyclase in rat liver microsomes

TBA

Oxidosqualene cyclase from Saccharomyces cerevisiae, Trypanosoma cruzi, Pneumocystis carinii and Arabidopsis thaliana expressed in yeast: a model for the development of novel antiparasitic agents.

Università

Design and evaluation of a novel series of 2,3-oxidosqualene cyclase inhibitors with low systemic exposure, relationship between pharmacokinetic properties and ocular toxicity.

Laboratoire Glaxosmithkline

Oxidosqualene cyclase inhibitors as antimicrobial agents.

University of Utah

Binding structures and potencies of oxidosqualene cyclase inhibitors with the homologous squalene-hopene cyclase.

Albert-Ludwigs-University of Freiburg

Design of Potent and Druglike Nonphenolic Inhibitors for Catechol O-Methyltransferase Derived from a Fragment Screening Approach Targeting the S-Adenosyl-l-methionine Pocket.

F. Hoffmann-La Roche

Novel 4-piperidinopyridine inhibitors of oxidosqualene cyclase-lanosterol synthase derived by consideration of inhibitor pK(a).

Astrazeneca

Evaluation of nitrocatechol chalcone and pyrazoline derivatives as inhibitors of catechol-O-methyltransferase and monoamine oxidase.

North-West University

A novel series of 4-piperidinopyridine and 4-piperidinopyrimidine inhibitors of 2,3-oxidosqualene cyclase-lanosterol synthase.

Astrazeneca

Synthesis and Evaluation of Bicyclic Hydroxypyridones as Inhibitors of Catechol

Lieber Institute For Brain Development

Quinuclidine inhibitors of 2,3-oxidosqualene cyclase-lanosterol synthase: optimization from lipid profiles.

Zeneca Pharmaceuticals

29-Methylidene-2,3-oxidosqualene derivatives as stereospecific mechanism-based inhibitors of liver and yeast oxidosqualene cyclase.

Università

Synthesis and inhibition studies of sulfur-substituted squalene oxide analogues as mechanism-based inhibitors of 2,3-oxidosqualene-lanosterol cyclase.

Simon Fraser University

Structural and stereoelectronic requirements for the inhibition of mammalian 2,3-oxidosqualene cyclase by substituted isoquinoline derivatives.

Laboratoires Fournier

NAD-based inhibitors with anticancer potential.

University of Minnesota

Discovery of N-(2,3,5-triazoyl)mycophenolic amide and mycophenolic epoxyketone as novel inhibitors of human IMPDH.

Hokkaido University

Antifungal benzo[b]thiophene 1,1-dioxide IMPDH inhibitors exhibit pan-assay interference (PAINS) profiles.

The University of Queensland

NMR Biochemical Assay for Oxidosqualene Cyclase: Evaluation of Inhibitor Activities on Trypanosoma cruzi and Human Enzymes.

National Institute of Advanced Industrial Science and Technology (Aist)

Optimization of 8-Hydroxyquinolines as Inhibitors of Catechol O-Methyltransferase.

Lieber Institute For Brain Development

Squalene analogues containing isopropylidene mimics as potential inhibitors of pig liver squalene epoxidase and oxidosqualene cyclase.

State University of New York

N-(1-oxododecyl)-4 alpha,10-dimethyl-8-aza-trans-decal-3 beta-ol: a potent competitive inhibitor of 2,3-oxidosqualene cyclase.

Marion Merrell Dow Research Institute