PMID

Data

Article Title

Organization

Virtual screening and experimental validation identify novel modulators of nuclear receptor RXRa from Drugbank database.

Xiamen University

Binding characterization, synthesis and biological evaluation of RXRa antagonists targeting the coactivator binding site.

Xiamen University

Synthesis and SAR study of modulators inhibiting tRXRa-dependent AKT activation.

Xiamen University

Cytosporone B is an agonist for nuclear orphan receptor Nur77.

Xiamen University

Fatty acids as natural specific inhibitors of the proto-oncogenic protein Shp2.

Xiamen University

Discovery of 5-(Pyrimidin-2-ylamino)-1

Xiamen University

Dihydrotrichodimerol Purified from the Marine Fungus

Xiamen University

A Molecular Toolbox of Positron Emission Tomography Tracers for General Anesthesia Mechanism Research.

Xiamen University

Discovery of bipyridine amide derivatives targeting pRXRα-PLK1 interaction for anticancer therapy.

Xiamen University

Inhibitory effects of phloridzin dihydrate on the activity of mushroom (Agaricus bisporus) tyrosinase.

Xiamen University

Discovery of 5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1H-indole-2-carboxamide derivatives as novel anti-cancer agents targeting Nur77.

Xiamen University

Design, synthesis, and biological evaluation of novel sulindac derivatives as partial agonists of PPARγ with potential anti-diabetic efficacy.

Xiamen University

Optimization of novel oxidative DIMs as Nur77 modulators of the Nur77-Bcl-2 apoptotic pathway.

Xiamen University

Discovery of methyl 3-((2-((1-(dimethylglycyl)-5-methoxyindolin-6-yl)amino)-5-(trifluoro-methyl) pyrimidin-4-yl)amino)thiophene-2-carboxylate as a potent and selective polo-like kinase 1 (PLK1) inhibitor for combating hepatocellular carcinoma.

Xiamen University

Design, synthesis, and biological evaluation of 5-((8-methoxy-2-methylquinolin-4-yl)amino)-1H-indole-2-carbohydrazide derivatives as novel Nur77 modulators.

Xiamen University

Discovery of 4-methyl-N-(4-((4-methylpiperazin- 1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-oxy)benzamide as a potent inhibitor of RET and its gatekeeper mutant.

Xiamen University

Discovery and optimization of 4-oxo-2-thioxo-thiazolidinones as NOD-like receptor (NLR) family, pyrin domain-containing protein 3 (NLRP3) inhibitors.

Xiamen University

Structure-Activity Relationship Study Enables the Discovery of a Novel

Xiamen University

Design, synthesis and biological evaluation of tetrazole-containing RXRα ligands as anticancer agents.

Xiamen University

SAR study of celastrol analogs targeting Nur77-mediated inflammatory pathway.

Xiamen University

Cytotoxic Components from Hypericum elodeoides Targeting RXRα and Inducing HeLa Cell Apoptosis through Caspase-8 Activation and PARP Cleavage.

Xiamen University

In Silico Discovery of JMJD6 Inhibitors for Cancer Treatment.

Xiamen University

Identification of a New RXRα Antagonist Targeting the Coregulator-Binding Site.

Xiamen University

Synthesis and antityrosinase activities of alkyl 3,4-dihydroxybenzoates.

Xiamen University

Substituted pyrazolopyrimidines useful as kinases inhibitors

Teligene

Ethynyl derivatives

Hoffmann-La Roche

Think twice: understanding the high potency of bis(phenyl)methane inhibitors of thrombin.

Philipps University Marburg