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Metadynamics for Perspective Drug Design: Computationally Driven Synthesis of New Protein-Protein Interaction Inhibitors Targeting the EphA2 Receptor.

University of Parma

Synthesis of Novel c(AmpRGD)-Sunitinib Dual Conjugates as Molecular Tools Targeting thea

University of Parma

Synthesis, Structural Elucidation, and Biological Evaluation of NSC12, an Orally Available Fibroblast Growth Factor (FGF) Ligand Trap for the Treatment of FGF-Dependent Lung Tumors.

University of Parma

¿(5)-Cholenoyl-amino acids as selective and orally available antagonists of the Eph-ephrin system.

University of Parma

Expanding the chemical space of human serine racemase inhibitors.

University of Parma

2-Aminonicotinic acid 1-oxides are chemically stable inhibitors of quinolinic acid synthesis in the mammalian brain: a step toward new antiexcitotoxic agents.

University of Parma

Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor.

University of Parma

Synthesis of (E)-8-(3-chlorostyryl)caffeine analogues leading to 9-deazaxanthine derivatives as dual A(2A) antagonists/MAO-B inhibitors.

University of Parma

Design of O-acetylserine sulfhydrylase inhibitors by mimicking nature.

University of Parma

Dibasic biphenyl H3 receptor antagonists: Steric tolerance for a lipophilic side chain.

University of Parma

Biphenyl-3-yl alkylcarbamates as fatty acid amide hydrolase (FAAH) inhibitors: steric effects of N-alkyl chain on rat plasma and liver stability.

University of Parma

Synthesis and structure-activity relationships for biphenyl H3 receptor antagonists with moderate anti-cholinesterase activity.

University of Parma

Inhibition of NaV1.6 sodium channel currents by a novel series of 1,4-disubstituted-triazole derivatives obtained via copper-catalyzed click chemistry.

University of Parma

Irreversible inhibition of epidermal growth factor receptor activity by 3-aminopropanamides.

University of Parma

Discovery of subnanomolar arginine-glycine-aspartate-based alphaVbeta3/alphaVbeta5 integrin binders embedding 4-aminoproline residues.

University of Parma

Grafting aminocyclopentane carboxylic acids onto the RGD tripeptide sequence generates low nanomolar alphaVbeta3/alphaVbeta5 integrin dual binders.

University of Parma

Simple, intuitive calculations of free energy of binding for protein-ligand complexes. 1. Models without explicit constrained water.

University of Parma

Novel irreversible epidermal growth factor receptor inhibitors by chemical modulation of the cysteine-trap portion.

University of Parma

5-Benzylidene-hydantoins: synthesis and antiproliferative activity on A549 lung cancer cell line.

University of Parma

Chemical modification of NSC12 leads to a specific FGF-trap with antitumor activity in multiple myeloma.

University of Parma

A sulfonyl fluoride derivative inhibits EGFR

University of Parma

Optimization of EphA2 antagonists based on a lithocholic acid core led to the identification of UniPR505, a new 3α-carbamoyloxy derivative with antiangiogenetic properties.

University of Parma

Balancing reactivity and antitumor activity: heteroarylthioacetamide derivatives as potent and time-dependent inhibitors of EGFR.

University of Parma

Benzisothiazolinone Derivatives as Potent Allosteric Monoacylglycerol Lipase Inhibitors That Functionally Mimic Sulfenylation of Regulatory Cysteines.

University of Parma

Multitarget CFTR Modulators Endowed with Multiple Beneficial Side Effects for Cystic Fibrosis Patients: Toward a Simplified Therapeutic Approach †.

University of Parma

Further insights into the SAR of α-substituted cyclopropylamine derivatives as inhibitors of histone demethylase KDM1A.

University of Parma

Long-lasting inhibition of EGFR autophosphorylation in A549 tumor cells by intracellular accumulation of non-covalent inhibitors.

University of Parma

N-(substituted-anilinoethyl)amides: design, synthesis, and pharmacological characterization of a new class of melatonin receptor ligands.

University of Parma

Dibasic non-imidazole histamine H3 receptor antagonists with a rigid biphenyl scaffold.

University of Parma

Analysis of structure-activity relationships for MT2 selective antagonists by melatonin MT1 and MT2 receptor models.

University of Parma

Three-dimensional quantitative structure-activity relationship studies on selected MT1 and MT2 melatonin receptor ligands: requirements for subtype selectivity and intrinsic activity modulation.

University of Parma

Targeting Eph/ephrin system in cancer therapy.

University of Parma

Tetrahydroquinoline Ring as a Versatile Bioisostere of Tetralin for Melatonin Receptor Ligands.

University of Parma

Atropisomerism and Conformational Equilibria: Impact on PI3Kδ Inhibition of 2-((6-Amino-9H-purin-9-yl)methyl)-5-methyl-3-(o-tolyl)quinazolin-4(3H)-one (IC87114) and Its Conformationally Restricted Analogs.

University of Parma