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84 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Discovery and evaluation of inhibitors to the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (IDO1): Probing the active site-inhibitor interactions.EBI
University of Auckland
Benzenesulphonamide inhibitors of the cytolytic protein perforin.EBI
University of Auckland
Novel pyrazolo[1,5-a]pyridines with improved aqueous solubility as p110a-selective PI3 kinase inhibitors.EBI
University of Auckland
Virtual screening and biophysical studies lead to HSP90 inhibitors.EBI
University of Auckland
Tyrosine Kinase Inhibitors. 20. Optimization of Substituted Quinazoline and Pyrido[3,4-d]pyrimidine Derivatives as Orally Active, Irreversible Inhibitors of the Epidermal Growth Factor Receptor Family.EBI
University of Auckland
Synthesis and biological evaluation of analogues of the potent ADAM8 inhibitor cyclo(RLsKDK) for the treatment of inflammatory diseases and cancer metastasis.EBI
University of Auckland
Diarylthiophenes as inhibitors of the pore-forming protein perforin.EBI
University of Auckland
Distinct Temporal Fingerprint for Cyclic Adenosine Monophosphate (cAMP) Signaling of Indole-2-carboxamides as Allosteric Modulators of the Cannabinoid Receptors.EBI
University of Auckland
Exploring the isoform selectivity of TGX-221 related pyrido[1,2-a]pyrimidinone-based Class IA PI 3-kinase inhibitors: synthesis, biological evaluation and molecular modelling.EBI
University of Auckland
Morpholylureas are a new class of potent and selective inhibitors of the type 5 17-ß-hydroxysteroid dehydrogenase (AKR1C3).EBI
University of Auckland
Targeting the Warburg Effect in cancer; relationships for 2-arylpyridazinones as inhibitors of the key glycolytic enzyme 6-phosphofructo-2-kinase/2,6-bisphosphatase 3 (PFKFB3).EBI
University of Auckland
Exploration of a series of 5-arylidene-2-thioxoimidazolidin-4-ones as inhibitors of the cytolytic protein perforin.EBI
University of Auckland
Discovery and characterisation of hydrazines as inhibitors of the immune suppressive enzyme, indoleamine 2,3-dioxygenase 1 (IDO1).EBI
University of Auckland
Synthesis and biological evaluation of novel phosphatidylinositol 3-kinase inhibitors: Solubilized 4-substituted benzimidazole analogs of 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474).EBI
University of Auckland
Synthesis and structure-activity relationships for 1-(4-(piperidin-1-ylsulfonyl)phenyl)pyrrolidin-2-ones as novel non-carboxylate inhibitors of the aldo-keto reductase enzyme AKR1C3.EBI
University of Auckland
3-(3,4-Dihydroisoquinolin-2(1H)-ylsulfonyl)benzoic Acids: highly potent and selective inhibitors of the type 5 17-ß-hydroxysteroid dehydrogenase AKR1C3.EBI
University of Auckland
Synthesis and biological evaluation of tyrosine modified analogues of thea4ß7 integrin inhibitor biotin-R8ERY.EBI
University of Auckland
Tyrosine modified analogues of thea4ß7 integrin inhibitor biotin-R8ERY prepared via Click Chemistry: synthesis and biological evaluation.EBI
University of Auckland
Synthesis and structure-activity relationships of soluble 8-substituted 4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of the Wee1 and Chk1 checkpoint kinases.EBI
University of Auckland
Structure-activity relationships for amide-, carbamate-, and urea-linked analogues of the tuberculosis drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).EBI
University of Auckland
Inhibition of the pore-forming protein perforin by a series of aryl-substituted isobenzofuran-1(3H)-ones.EBI
University of Auckland
Novel pyrazolo[1,5-a]pyridines as p110a-selective PI3 kinase inhibitors: Exploring the benzenesulfonohydrazide SAR.EBI
University of Auckland
Discovery of pyrazolo[1,5-a]pyridines as p110a-selective PI3 kinase inhibitors.EBI
University of Auckland
Synthesis and biological evaluation of novel analogues of the pan class I phosphatidylinositol 3-kinase (PI3K) inhibitor 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474).EBI
University of Auckland
Inhibition of the cellular function of perforin by 1-amino-2,4-dicyanopyrido[1,2-a]benzimidazoles.EBI
University of Auckland
Chemical and biological explorations of the electrophilic reactivity of the bioactive marine natural product halenaquinone with biomimetic nucleophiles.EBI
University of Auckland
Phosphoinositide-3-kinase (PI3K) inhibitors: identification of new scaffolds using virtual screening.EBI
University of Auckland
Dihydrofuro[3,4-c]pyridinones as inhibitors of the cytolytic effects of the pore-forming glycoprotein perforin.EBI
University of Auckland
Synthesis and structure-activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of Wee1 and Chk1 checkpoint kinases.EBI
University of Auckland
Synthesis, biological evaluation and molecular modelling of sulfonohydrazides as selective PI3K p110alpha inhibitors.EBI
University of Auckland
Fragment-based and structure-guided discovery of perforin inhibitors.EBI
University of Auckland
Hypoxia-activated prodrugs of phenolic olaparib analogues for tumour-selective chemosensitisation.EBI
University of Auckland
4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione inhibitors of the checkpoint kinase Wee1. Structure-activity relationships for chromophore modification and phenyl ring substitution.EBI
University of Auckland
Small Molecule Inhibitors of Lymphocyte Perforin as Focused Immunosuppressants for Infection and Autoimmunity.EBI
University of Auckland
Isolation and biological activity of azocine and azocane alkaloids.EBI
University of Auckland
Structure-activity relationships for 2-anilino-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-ones as inhibitors of the cellular checkpoint kinase Wee1.EBI
University of Auckland
Heteroaryl ether analogues of an antileishmanial 7-substituted 2-nitroimidazooxazine lead afford attenuated hERG risk: In vitro and in vivo appraisal.EBI
University of Auckland
Parallel discovery of selective and dual inhibitors of tryptophan dioxygenases IDO1 and TDO2 with a newly-modified enzymatic assay.EBI
University of Auckland
Discovery of novel Hsp90 C-terminal domain inhibitors that disrupt co-chaperone binding.EBI
University of Auckland
Re-evaluating pretomanid analogues for Chagas disease: Hit-to-lead studies reveal both in vitro and in vivo trypanocidal efficacy.EBI
University of Auckland
Discovery of novel phosphatidylcholine-specific phospholipase C drug-like inhibitors as potential anticancer agents.EBI
University of Auckland
Pyridine alkaloids with activity in the central nervous system.EBI
University of Auckland
Variations in the C-unit of bedaquiline provides analogues with improved biology and pharmacology.EBI
University of Auckland
Synthesis and biological evaluation of solubilized sulfonamide analogues of the phosphatidylinositol 3-kinase inhibitor ZSTK474.EBI
University of Auckland
Structure-activity relationships for unit C pyridyl analogues of the tuberculosis drug bedaquiline.EBI
University of Auckland
Tyrosine kinase inhibitors. 17. Irreversible inhibitors of the epidermal growth factor receptor: 4-(phenylamino)quinazoline- and 4-(phenylamino)pyrido[3,2-d]pyrimidine-6-acrylamides bearing additional solubilizing functions.EBI
University of Auckland
Synthesis and Evaluation of Novel TLR2 Agonists as Potential Adjuvants for Cancer Vaccines.EBI
University of Auckland
Ketamine esters and amides as short-acting anaesthetics: Structure-activity relationships for the side-chain.EBI
University of Auckland
Tyrosine kinase inhibitors. 15. 4-(Phenylamino)quinazoline and 4-(phenylamino)pyrido[d]pyrimidine acrylamides as irreversible inhibitors of the ATP binding site of the epidermal growth factor receptor.EBI
University of Auckland
Naturally Occurring Lumazines.EBI
University of Auckland
Divalent cannabinoid-1 receptor ligands: A linker attachment point survey of SR141716A for development of high-affinity CB1R molecular probes.EBI
University of Auckland
Novel Cell-Penetrating Peptide Conjugated Proteasome Inhibitors: Anticancer and Antifungal Investigations.EBI
University of Auckland
Inhibition of the Cytolytic Protein Perforin Prevents Rejection of Transplanted Bone Marrow Stem Cells in Vivo.EBI
University of Auckland
Tyrosine kinase inhibitors. 4. Structure-activity relationships among N- and 3-substituted 2,2'-dithiobis(1H-indoles) for in vitro inhibition of receptor and nonreceptor protein tyrosine kinases.EBI
University of Auckland
4-anilino-5-carboxamido-2-pyridone derivatives as noncompetitive inhibitors of mitogen-activated protein kinase kinase.EBI
University of Auckland
Hybrid compounds from chalcone and 1,2-benzothiazine pharmacophores as selective inhibitors of alkaline phosphatase isozymes.EBI
University of Auckland
Natural Products with Heteroatom-Rich Ring Systems.EBI
University of Auckland
Structure-activity relationships for analogs of the tuberculosis drug bedaquiline with the naphthalene unit replaced by bicyclic heterocycles.EBI
University of Auckland
Mushroom-Derived Indole Alkaloids.EBI
University of Auckland
Synthesis and evaluation of analogues of the tuberculosis drug bedaquiline containing heterocyclic B-ring units.EBI
University of Auckland
Synthesis and biological evaluation of sulfonamide analogues of the phosphatidylinositol 3-kinase inhibitor ZSTK474.EBI
University of Auckland
6-Cyano Analogues of Bedaquiline as Less Lipophilic and Potentially Safer Diarylquinolines for Tuberculosis.EBI
University of Auckland
Substituted arylsulphonamides as inhibitors of perforin-mediated lysis.EBI
University of Auckland
An SAR study of hydroxy-trifluoromethylpyrazolines as inhibitors of Orai1-mediated store operated CaEBI
University of Auckland
7-Substituted 2-Nitro-5,6-dihydroimidazo[2,1-b][1,3]oxazines: Novel Antitubercular Agents Lead to a New Preclinical Candidate for Visceral Leishmaniasis.EBI
University of Auckland
Development of (6 R)-2-Nitro-6-[4-(trifluoromethoxy)phenoxy]-6,7-dihydro-5 H-imidazo[2,1- b][1,3]oxazine (DNDI-8219): A New Lead for Visceral Leishmaniasis.EBI
University of Auckland
Pyrrolopyrimidine nucleosides and analogs thereofBDB
Chimerix
Diazaspiroalkaneone-substituted oxazole derivatives as spleen tyrosine kinase inhibitorsBDB
Ab Science
Imidazopyridines and imidazopyrazines as LSD1 inhibitorsBDB
Incyte
(R)-2-methyl-piperazine derivatives as CXCR3 receptor modulatorsBDB
Idorsia Pharmaceuticals
Aminoquinazoline derivatives and their salts and methods of use thereofBDB
Sunshine Lake Pharma
PPAR-sparing compounds for the treatment of metabolic diseasesBDB
Metabolic Solutions Development
Pharmaceutical compositions comprising estetrol derivatives for use in cancer therapyBDB
Donesta Bioscience
Method of treatment using substituted pyrazolo[1,5-a] pyrimidine compoundsBDB
Array Biopharma
Substituted [1,2,4]triazolo[4,3-a]pyrazines as P2X7 modulatorsBDB
Janssen Pharmaceutica
Substituted pyrazolopyrimidinylamino-indazolesBDB
Bayer Pharma Aktiengesellschaft
Enhancer of zeste homolog 2 inhibitorsBDB
Glaxosmithkline
Complement pathway modulators and uses thereofBDB
Novartis
ERK inhibitorsBDB
Merck Sharp & Dohme
Thermodynamics of antigen-antibody binding using specific anti-lysozyme antibodies.BDB
University of Maryland Biotechnology Institute
The affinity maturation of anti-4-hydroxy-3-nitrophenylacetyl mouse monoclonal antibody. A calorimetric study of the antigen-antibody interaction.BDB
Institute of Physical and Chemical Research (Riken)
Salt links dominate affinity of antibody HyHEL-5 for lysozyme through enthalpic contributions.BDB
University of Houston