65 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
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Discovery of an Orally Selective Inhibitor of Signal Transducer and Activator of Transcription 3 Using Advanced Multiple Ligand Simultaneous Docking.
The Ohio State University
Structure-based optimization of a peptidyl inhibitor against calcineurin-nuclear factor of activated T cell (NFAT) interaction.
The Ohio State University
A Selective, Cell-Permeable Nonphosphorylated Bicyclic Peptidyl Inhibitor against Peptidyl-Prolyl Isomerase Pin1.
The Ohio State University
Exploitation of the ability of¿-tocopherol to facilitate membrane co-localization of Akt and PHLPP1 to develop PHLPP1-targeted Akt inhibitors.
The Ohio State University
In vitro evaluation of potential bitterness-masking terpenoids from the Canada goldenrod (Solidago canadensis).
The Ohio State University
Anticancer activity and SAR studies of substituted 1,4-naphthoquinones.
The Ohio State University
Discovery of benzamide analogs as negative allosteric modulators of human neuronal nicotinic receptors: pharmacophore modeling and structure-activity relationship studies.
The Ohio State University
Discovery of novel STAT3 small molecule inhibitors via in silico site-directed fragment-based drug design.
The Ohio State University
Heterobivalent dual-target probe for targeting GRP and Y1 receptors on tumor cells.
The Ohio State University
3D-QSAR and 3D-QSSR models of negative allosteric modulators facilitate the design of a novel selective antagonist of humana4ß2 neuronal nicotinic acetylcholine receptors.
The Ohio State University
Structure-activity relationship studies of sulfonylpiperazine analogues as novel negative allosteric modulators of human neuronal nicotinic receptors.
The Ohio State University
Development of a novel class of glucose transporter inhibitors.
The Ohio State University
The relevance of higher plants in lead compound discovery programs.
The Ohio State University
Cytotoxic and NF-kappaB inhibitory constituents of Artocarpus rigida.
The Ohio State University
Novel sulfonanilide analogs decrease aromatase activity in breast cancer cells: synthesis, biological evaluation, and ligand-based pharmacophore identification.
The Ohio State University
Identification and characterization of a novel integrin-linked kinase inhibitor.
The Ohio State University
Cytotoxic and NF-κB inhibitory constituents of the stems of Cratoxylum cochinchinense and their semisynthetic analogues.
The Ohio State University
Isolation and characterization of minor analogues of silvestrol and other constituents from a large-scale re-collection of Aglaia foveolata.
The Ohio State University
Cytotoxic xanthone constituents of the stem bark of Garcinia mangostana (mangosteen).
The Ohio State University
Synthesis and screening of a cyclic peptide library: discovery of small-molecule ligands against human prolactin receptor.
The Ohio State University
Synthesis and biological evaluation of selective aromatase expression regulators in breast cancer cells.
The Ohio State University
Bifunctional degraders of cyclin dependent kinase 9 (CDK9): Probing the relationship between linker length, properties, and selective protein degradation.
The Ohio State University
Design and synthesis of substrate and intermediate analogue inhibitors of S-ribosylhomocysteinase.
The Ohio State University
Novel sulfonanilide analogues suppress aromatase expression and activity in breast cancer cells independent of COX-2 inhibition.
The Ohio State University
1,3-Dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Expanding Structural Diversity and the Antibacterial Spectrum.
The Ohio State University
Modulating β-arrestin 2 recruitment at the δ- and μ-opioid receptors using peptidomimetic ligands.
The Ohio State University
Macrocyclic inhibitors for peptide deformylase: a structure-activity relationship study of the ring size.
The Ohio State University
Optimization of TopoIV Potency, ADMET Properties, and hERG Inhibition of 5-Amino-1,3-dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Identification of a Lead with
The Ohio State University
Peptidyl aldehydes as slow-binding inhibitors of dual-specificity phosphatases.
The Ohio State University
Peptidyl hydroxamic acids as methionine aminopeptidase inhibitors.
The Ohio State University
Structure-based design of a macrocyclic inhibitor for peptide deformylase.
The Ohio State University
Novel bacterial topoisomerase inhibitors derived from isomannide.
The Ohio State University
Synthesis and estrogen receptor binding affinities of 7-hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-ones containing a basic side chain.
The Ohio State University
Dioxane-Linked Amide Derivatives as Novel Bacterial Topoisomerase Inhibitors against Gram-Positive
The Ohio State University
alpha-bromoacetophenone derivatives as neutral protein tyrosine phosphatase inhibitors: structure-Activity relationship.
The Ohio State University
Development of Potential Antitumor Agents from the Scaffolds of Plant-Derived Terpenoid Lactones.
The Ohio State University
An improved synthesis of the C-linked glucuronide of N-(4-hydroxyphenyl)retinamide.
The Ohio State University
Cyclic Peptidyl Inhibitors against CAL/CFTR Interaction for Treatment of Cystic Fibrosis.
The Ohio State University
Rational design of cell-permeable cyclic peptides containing a d-Pro-l-Pro motif.
The Ohio State University
Design and synthesis of Pfmrk inhibitors as potential antimalarial agents.
The Ohio State University
An unhydrolyzable analogue of N-(4-hydroxyphenyl)retinamide. synthesis and preliminary biological studies.
The Ohio State University
Enhancing the Cell Permeability of Stapled Peptides with a Cyclic Cell-Penetrating Peptide.
The Ohio State University
Potential Anticancer Agents Characterized from Selected Tropical Plants.
The Ohio State University
An Isoquinoline Scaffold as a Novel Class of Allosteric HIV-1 Integrase Inhibitors.
The Ohio State University
Drug design targeting protein-protein interactions (PPIs) using multiple ligand simultaneous docking (MLSD) and drug repositioning: discovery of raloxifene and bazedoxifene as novel inhibitors of IL-6/GP130 interface.
The Ohio State University
Design, synthesis and biological studies of novel tubulin inhibitors.
The Ohio State University
Membrane permeable cyclic peptidyl inhibitors against human Peptidylprolyl Isomerase Pin1.
The Ohio State University
Synthesis, biological evaluation, and molecular modeling of 3,5-substituted-N1-phenyl-N4,N4-di-n-butylsulfanilamides as antikinetoplastid antimicrotubule agents.
The Ohio State University
Conformationally restricted analogs of Combretastatin A-4 derived from SU5416.
The Ohio State University
Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors.
The Ohio State University
Zn2+-chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors.
The Ohio State University
Cytotoxic and NF-κB and mitochondrial transmembrane potential inhibitory pentacyclic triterpenoids from Syzygium corticosum and their semi-synthetic derivatives.
The Ohio State University
Synthesis and anti-staphylococcal activity of novel bacterial topoisomerase inhibitors with a 5-amino-1,3-dioxane linker moiety.
The Ohio State University
Novel pyrrolopyrimidines as Mps1/TTK kinase inhibitors for breast cancer.
The Ohio State University
Hepatic glucocorticoid receptor antagonism is sufficient to reduce elevated hepatic glucose output and improve glucose control in animal models of type 2 diabetes.
Abbott Laboratories
Differences in the central nervous system distribution and pharmacology of the mouse 5-hydroxytryptamine-6 receptor compared with rat and human receptors investigated by radioligand binding, site-directed mutagenesis, and molecular modeling.
Glaxosmithkline