PMID

Data

Article Title

Organization

Macrocyclic MEK1/2 inhibitor with efficacy in a mouse model of cardiomyopathy caused by lamin A/C gene mutation.

Columbia University

Incorporation of metabolically stable ketones into a small molecule probe to increase potency and water solubility.

Columbia University

Synthesis of quinoline derivatives: discovery of a potent and selective phosphodiesterase 5 inhibitor for the treatment of Alzheimer's disease.

Columbia University

Synthesis and structure-activity relationship of piperidine-derived non-urea soluble epoxide hydrolase inhibitors.

Columbia University

Discovery of a novel submicromolar inhibitor of the lymphoid specific tyrosine phosphatase.

Columbia University

RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels.

Columbia University

Identification of N-(quinolin-8-yl)benzenesulfonamides as agents capable of down-regulating NFkappaB activity within two separate high-throughput screens of NFkappaB activation.

Columbia University

Design, synthesis and evaluation of non-urea inhibitors of soluble epoxide hydrolase.

Columbia University

Synthesis and in vivo evaluation of [11C]MPTQ: a potential PET tracer for alpha2A-adrenergic receptors.

Columbia University

Discovery of potent non-urea inhibitors of soluble epoxide hydrolase.

Columbia University

Potent inhibitors of Huntingtin protein aggregation in a cell-based assay.

Columbia University

Discovery of novel small molecule cell type-specific enhancers of NF-kappaB nuclear translocation.

Columbia University

Two new prenylated 3-benzoxepin derivatives as cyclooxygenase inhibitors from Perilla frutescens var. acuta.

Columbia University

Optimizing metabolic stability of phosphodiesterase 5 inhibitors: Discovery of a potent N-(pyridin-3-ylmethyl)quinoline derivative targeting synaptic plasticity.

Columbia University

Preparation of 7-substituted ginkgolide derivatives: potent platelet activating factor (PAF) receptor antagonists.

Columbia University

Ginkgolide derivatives for photolabeling studies: preparation and pharmacological evaluation.

Columbia University

Structural Elucidation of a Small Molecule Inhibitor of Protein Disulfide Isomerase.

Columbia University

Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter.

Columbia University

Identification of a Novel 1,2,3,4-Tetrahydrobenzo[b][1,6]naphthyridine Analogue as a Potent Phosphodiesterase 5 Inhibitor with Improved Aqueous Solubility for the Treatment of Alzheimer's Disease.

Columbia University

FOUR-MEMBERED FUSED RING COMPOUND AND PREPARATION METHOD AND USE THEREOF

Jiangsu Hansoh Pharmaceutical Group

ANTIVIRAL APPLICATION OF NUCLEOSIDE ANALOG OR COMBINATION FORMULATION CONTAINING NUCLEOSIDE ANALOG

Shanghai Institute of Materia Medica

Compounds and their use

Astrazeneca

TETRAHYDROISOQUINOLINE DERIVATIVE AND USE THEREOF

Medshine Discovery

AMINO ALCOHOL COMPOUNDS AND USES THEREOF

Kineta

Protein kinase modulators

Cylene Pharmaceuticals

Substituted benzene compounds

Epizyme

Heterocyclic compound as Syk inhibitor and/or Syk-HDAC dual inhibitor

Hangzhou Innogate Pharma

Combinations comprising substituted imidazo[1,5-α]pyrazinones as PDE1 inhibitors

H. Lundbeck

Indolizine derivatives, composition and methods of use

Shanghai Fochon Pharmaceutical

Substituted pyrrolidines as G-protein coupled receptor 43 agonists

Epics Therapeutics

Kv1.3 inhibitors and their medical applications

4Sc

Bipyrazole derivatives as JAK inhibitors

Incyte

Pyridine-2-amides useful as CB2 agonists

Hoffmann-La Roche

Fused heterocyclic derivatives and methods of use

Amgen

4-(substituted anilino)-quinazoline derivatives useful as tyrosine kinase inhibitors

Qilu Pharmaceutical

Pyrazole oxadiazole derivatives as S1P1 agonists

Merck Serono