Compile Data Set for Download or QSAR
Report error Found 3 Enz. Inhib. hit(s) with all data for entry = 50048238
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Columbia University

Curated by ChEMBL
LigandPNGBDBM50209764(CHEMBL3884776)
Affinity DataIC50: 21nMAssay Description:Inhibition of full length human GST-tagged MEK1 using ERK1/ERK2 peptide substrate in presence of ATP by ADP-Glo chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50209763(CHEMBL3883792)
Affinity DataIC50: 400nMAssay Description:Inhibition of MEK1/2 in human HT-29 cells assessed as reduction in cell proliferation after 72 hrs by CellTiter-Glo assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50209763(CHEMBL3883792)
Affinity DataIC50: 400nMAssay Description:Inhibition of MEK1/2 in human HT-29 cells assessed as reduction in cell proliferation after 72 hrs by CellTiter-Glo assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed