Compile Data Set for Download or QSAR
Report error Found 71 Enz. Inhib. hit(s) with all data for entry = 50020503
TargetHistone deacetylase 6(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM110036(US8609678, 2-((2-chlorophenyl)(phenyl)amino)-N-(7-...)
Affinity DataIC50: 3nMAssay Description:Inhibition of HDAC6 (unknown origin) using fluorescence tripeptide as substrate preincubated with compound for 10 mins followed by substrate addition...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone deacetylase 6(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM22449(N-(4-{(2R,4R,6S)-4-{[(4,5-diphenyl-1,3-oxazol-2-yl...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant HDAC6 using RHKKAc (379 to 382 residues) as substrateMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone deacetylase 6(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50439674(US8609678, 2-(diphenylamino)-N-(7-(hydroxyamino)-7...)
Affinity DataIC50: 5nMAssay Description:Inhibition of HDAC6 (unknown origin) using fluorescence tripeptide as substrate preincubated with compound for 10 mins followed by substrate addition...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone deacetylase 6(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50630619(CHEMBL5440192)
Affinity DataIC50: 5nMAssay Description:Inhibition of full length N-terminal GST-tagged human recombinant HDAC6 (1 to 1215 residues) expressed in Sf9 cells using ZMAL as fluorogenic substra...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone deacetylase 6(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50630617(CHEMBL5407634)
Affinity DataIC50: 10nMAssay Description:Inhibition of full length N-terminal GST-tagged human recombinant HDAC6 (1 to 1215 residues) expressed in Sf9 cells using ZMAL as fluorogenic substra...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone deacetylase 6(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50630620(CHEMBL5424768)
Affinity DataIC50: 11nMAssay Description:Inhibition of full length N-terminal GST-tagged human recombinant HDAC6 (1 to 1215 residues) expressed in Sf9 cells using ZMAL as fluorogenic substra...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone deacetylase 6(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50630625(CHEMBL5422921)
Affinity DataIC50: 15nMAssay Description:Inhibition of human recombinant HDAC6 using RHKKAc (379 to 382 residues) as substrateMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone deacetylase 6(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50630618(CHEMBL5426948)
Affinity DataIC50: 17nMAssay Description:Inhibition of full length N-terminal GST-tagged human recombinant HDAC6 (1 to 1215 residues) expressed in Sf9 cells using ZMAL as fluorogenic substra...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone deacetylase 6(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50630622(CHEMBL5404317)
Affinity DataIC50: 18nMAssay Description:Inhibition of full length N-terminal GST-tagged human recombinant HDAC6 (1 to 1215 residues) expressed in Sf9 cells using ZMAL as fluorogenic substra...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone deacetylase 6(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50630614(CHEMBL5400623)
Affinity DataIC50: 25nMAssay Description:Inhibition of full length N-terminal GST-tagged human recombinant HDAC6 (1 to 1215 residues) expressed in Sf9 cells using ZMAL as fluorogenic substra...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50276140(CHEMBL4129995)
Affinity DataIC50: 28nMAssay Description:Inhibition of N-terminal 6His/SUMO fused human Sirt2 (38 to 356 residues) expressed in Escherichia coli BL21 using acetyl-H3K9 as substrate preincuba...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone deacetylase 6(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 30nMAssay Description:Inhibition of full length N-terminal GST-tagged human recombinant HDAC6 (1 to 1215 residues) expressed in Sf9 cells using ZMAL as fluorogenic substra...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone deacetylase 6(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50630623(CHEMBL5438435)
Affinity DataIC50: 32nMAssay Description:Inhibition of full length N-terminal GST-tagged human recombinant HDAC6 (1 to 1215 residues) expressed in Sf9 cells using ZMAL as fluorogenic substra...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone deacetylase 6(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50630615(CHEMBL5410652)
Affinity DataIC50: 42nMAssay Description:Inhibition of full length N-terminal GST-tagged human recombinant HDAC6 (1 to 1215 residues) expressed in Sf9 cells using ZMAL as fluorogenic substra...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone deacetylase 6(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50630616(CHEMBL5412573)
Affinity DataIC50: 43nMAssay Description:Inhibition of full length N-terminal GST-tagged human recombinant HDAC6 (1 to 1215 residues) expressed in Sf9 cells using ZMAL as fluorogenic substra...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 110nMAssay Description:Inhibition of C-terminal His-tagged human recombinant HDAC3 (1 to 428 residues)/N-terminal GST tagged human NcoR2 (395 to 489 residues) expressed in ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone deacetylase 1(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 120nMAssay Description:Inhibition of full length C-terminal 6His/FLAG-tagged human recombinant HDAC1 (1 to 482 residues) purified as tubulin complex expressed in Sf9 cells ...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50459845(CHEMBL4227437)
Affinity DataIC50: 120nMAssay Description:Inhibition of N-terminal 6His-tagged human Sirt2 (25 to 389 residues) expressed in Escherichia coli BL21(DE3) using ZMAL as substrate incubated for 4...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50459845(CHEMBL4227437)
Affinity DataIC50: 120nMAssay Description:Inhibition of recombinant human Sirt2 (56 to 356 residues) expressed in Escherichia coli BL21 Star (DE3) using ZMAL as substrate incubated for 4 hrs ...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50630619(CHEMBL5440192)
Affinity DataIC50: 140nMAssay Description:Inhibition of C-terminal His-tagged human recombinant HDAC3 (1 to 428 residues)/N-terminal GST tagged human NcoR2 (395 to 489 residues) expressed in ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50459842(CHEMBL4228286)
Affinity DataIC50: 140nMAssay Description:Inhibition of C-terminal His-tagged human recombinant HDAC3 (1 to 428 residues)/N-terminal GST tagged human NcoR2 (395 to 489 residues) expressed in ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone deacetylase 6(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50630613(CHEMBL5422428)
Affinity DataIC50: 150nMAssay Description:Inhibition of full length N-terminal GST-tagged human recombinant HDAC6 (1 to 1215 residues) expressed in Sf9 cells using ZMAL as fluorogenic substra...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50630615(CHEMBL5410652)
Affinity DataIC50: 150nMAssay Description:Inhibition of recombinant human Sirt2 (56 to 356 residues) expressed in Escherichia coli BL21 Star (DE3) using ZMAL as substrate incubated for 4 hrs ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50459842(CHEMBL4228286)
Affinity DataIC50: 160nMAssay Description:Inhibition of N-terminal 6His-tagged human Sirt2 (25 to 389 residues) expressed in Escherichia coli BL21(DE3) using ZMAL as substrate incubated for 4...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase 2(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM19149(Zolinza | suberoylanilide hydroxamic acid | CHEMBL...)
Affinity DataIC50: 160nMAssay Description:Inhibition of full length C-terminal FLAG-tagged human recombinant HDAC2 (1 to 488 residues) expressed in Sf9 cells using ZMAL as fluorogenic substra...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50459842(CHEMBL4228286)
Affinity DataIC50: 200nMAssay Description:Inhibition of Sireal-TAMRA tracer binding to Sirt2 in HEK293 cells incubated for 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase 1(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50630620(CHEMBL5424768)
Affinity DataIC50: 210nMAssay Description:Inhibition of full length C-terminal 6His/FLAG-tagged human recombinant HDAC1 (1 to 482 residues) purified as tubulin complex expressed in Sf9 cells ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone deacetylase 1(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50630619(CHEMBL5440192)
Affinity DataIC50: 210nMAssay Description:Inhibition of full length C-terminal 6His/FLAG-tagged human recombinant HDAC1 (1 to 482 residues) purified as tubulin complex expressed in Sf9 cells ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50459842(CHEMBL4228286)
Affinity DataIC50: 220nMAssay Description:Inhibition of recombinant human Sirt2 (56 to 356 residues) expressed in Escherichia coli BL21 Star (DE3) using ZMAL as substrate incubated for 4 hrs ...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50630616(CHEMBL5412573)
Affinity DataIC50: 320nMAssay Description:Inhibition of recombinant human Sirt2 (56 to 356 residues) expressed in Escherichia coli BL21 Star (DE3) using ZMAL as substrate incubated for 4 hrs ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone deacetylase 2(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50630619(CHEMBL5440192)
Affinity DataIC50: 340nMAssay Description:Inhibition of full length C-terminal FLAG-tagged human recombinant HDAC2 (1 to 488 residues) expressed in Sf9 cells using ZMAL as fluorogenic substra...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50630624(CHEMBL5416341)
Affinity DataIC50: 400nMAssay Description:Inhibition of SIRT2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50148781(CHEMBL3770903)
Affinity DataIC50: 440nMAssay Description:Inhibition of human Sirt2 (25 to 389 residues) expressed in Escherichia coli BL21(DE3) Codon plus RIPL cells using ZMAL as substrate incubated for 4 ...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetHistone deacetylase 1(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50630618(CHEMBL5426948)
Affinity DataIC50: 460nMAssay Description:Inhibition of full length C-terminal 6His/FLAG-tagged human recombinant HDAC1 (1 to 482 residues) purified as tubulin complex expressed in Sf9 cells ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50630617(CHEMBL5407634)
Affinity DataIC50: 480nMAssay Description:Inhibition of recombinant human Sirt2 (56 to 356 residues) expressed in Escherichia coli BL21 Star (DE3) using ZMAL as substrate incubated for 4 hrs ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50630619(CHEMBL5440192)
Affinity DataIC50: 480nMAssay Description:Inhibition of recombinant human Sirt2 (56 to 356 residues) expressed in Escherichia coli BL21 Star (DE3) using ZMAL as substrate incubated for 4 hrs ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50630618(CHEMBL5426948)
Affinity DataIC50: 540nMAssay Description:Inhibition of recombinant human Sirt2 (56 to 356 residues) expressed in Escherichia coli BL21 Star (DE3) using ZMAL as substrate incubated for 4 hrs ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50630616(CHEMBL5412573)
Affinity DataIC50: 560nMAssay Description:Inhibition of Sireal-TAMRA tracer binding to Sirt2 in HEK293 cells incubated for 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50630614(CHEMBL5400623)
Affinity DataIC50: 560nMAssay Description:Inhibition of recombinant human Sirt2 (56 to 356 residues) expressed in Escherichia coli BL21 Star (DE3) using ZMAL as substrate incubated for 4 hrs ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone deacetylase 1(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50630617(CHEMBL5407634)
Affinity DataIC50: 600nMAssay Description:Inhibition of full length C-terminal 6His/FLAG-tagged human recombinant HDAC1 (1 to 482 residues) purified as tubulin complex expressed in Sf9 cells ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone deacetylase 1(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50630614(CHEMBL5400623)
Affinity DataIC50: 620nMAssay Description:Inhibition of full length C-terminal 6His/FLAG-tagged human recombinant HDAC1 (1 to 482 residues) purified as tubulin complex expressed in Sf9 cells ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone deacetylase 6(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50630621(CHEMBL5438818)
Affinity DataIC50: 650nMAssay Description:Inhibition of full length N-terminal GST-tagged human recombinant HDAC6 (1 to 1215 residues) expressed in Sf9 cells using ZMAL as fluorogenic substra...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50630615(CHEMBL5410652)
Affinity DataIC50: 710nMAssay Description:Inhibition of C-terminal His-tagged human recombinant HDAC3 (1 to 428 residues)/N-terminal GST tagged human NcoR2 (395 to 489 residues) expressed in ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone deacetylase 1(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50630622(CHEMBL5404317)
Affinity DataIC50: 810nMAssay Description:Inhibition of full length C-terminal 6His/FLAG-tagged human recombinant HDAC1 (1 to 482 residues) purified as tubulin complex expressed in Sf9 cells ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50630616(CHEMBL5412573)
Affinity DataIC50: 880nMAssay Description:Inhibition of recombinant human Sirt2 (56 to 356 residues) expressed in Escherichia coli BL21 Star (DE3) mediated demyristoylation activity using pep...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone deacetylase 1(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50630615(CHEMBL5410652)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of full length C-terminal 6His/FLAG-tagged human recombinant HDAC1 (1 to 482 residues) purified as tubulin complex expressed in Sf9 cells ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50459842(CHEMBL4228286)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of recombinant human Sirt2 (56 to 356 residues) expressed in Escherichia coli BL21 Star (DE3) mediated demyristoylation activity using ZMM...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50630615(CHEMBL5410652)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of recombinant human Sirt2 (56 to 356 residues) expressed in Escherichia coli BL21 Star (DE3) mediated demyristoylation activity using ZMM...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone deacetylase 2(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50630615(CHEMBL5410652)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of full length C-terminal FLAG-tagged human recombinant HDAC2 (1 to 488 residues) expressed in Sf9 cells using ZMAL as fluorogenic substra...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetHistone deacetylase 1(Human)
Leipzig University

Curated by ChEMBL
LigandPNGBDBM50630613(CHEMBL5422428)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of full length C-terminal 6His/FLAG-tagged human recombinant HDAC1 (1 to 482 residues) purified as tubulin complex expressed in Sf9 cells ...More data for this Ligand-Target Pair
In DepthDetails
PubMed
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