Compile Data Set for Download or QSAR
Report error Found 1061 Enz. Inhib. hit(s) with Target = 'Cell division cycle 7-related protein kinase'
LigandPNGBDBM50365700(CHEMBL1958414)
Affinity DataEC50:  60nMAssay Description:Inhibition of CDC7/DBF4-mediated MCM2 phosphorylation in human HCT116 cells after 6 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50365701(CHEMBL1958415)
Affinity DataEC50:  300nMAssay Description:Inhibition of CDC7/DBF4-mediated MCM2 phosphorylation in human HCT116 cells after 6 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50365702(CHEMBL1958416)
Affinity DataEC50:  300nMAssay Description:Inhibition of CDC7/DBF4-mediated MCM2 phosphorylation in human HCT116 cells after 6 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50365703(CHEMBL1958417)
Affinity DataEC50:  2.61E+3nMAssay Description:Inhibition of CDC7/DBF4-mediated MCM2 phosphorylation in human HCT116 cells after 6 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50365704(CHEMBL1958418)
Affinity DataEC50:  410nMAssay Description:Inhibition of CDC7/DBF4-mediated MCM2 phosphorylation in human HCT116 cells after 6 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50365705(CHEMBL1958419)
Affinity DataEC50:  1.78E+3nMAssay Description:Inhibition of CDC7/DBF4-mediated MCM2 phosphorylation in human HCT116 cells after 6 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50365706(CHEMBL1958420)
Affinity DataEC50:  300nMAssay Description:Inhibition of CDC7/DBF4-mediated MCM2 phosphorylation in human HCT116 cells after 6 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50365708(CHEMBL1958405)
Affinity DataEC50:  60nMAssay Description:Inhibition of CDC7/DBF4-mediated MCM2 phosphorylation in human HCT116 cells after 6 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50365698(CHEMBL1958411)
Affinity DataEC50:  15nMAssay Description:Inhibition of CDC7/DBF4-mediated MCM2 phosphorylation in human HCT116 cells after 6 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50365699(CHEMBL1958412)
Affinity DataEC50:  143nMAssay Description:Inhibition of CDC7/DBF4-mediated MCM2 phosphorylation in human HCT116 cells after 6 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50365709(CHEMBL1958413)
Affinity DataEC50:  180nMAssay Description:Inhibition of CDC7/DBF4-mediated MCM2 phosphorylation in human HCT116 cells after 6 hrs by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50253706(CHEMBL4083927)
Affinity DataKd:  0.541nMAssay Description:Binding affinity to recombinant human full length Cdc7 (1 to 574 residues)/human N-terminal GST-tagged ASK (1 to 674 residues) expressed in baculovir...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50253675(CHEMBL4080367)
Affinity DataKd:  2.80nMAssay Description:Binding affinity to recombinant human full length Cdc7 (1 to 574 residues)/human N-terminal GST-tagged ASK (1 to 674 residues) expressed in baculovir...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50253762(CHEMBL4098392)
Affinity DataKd:  1.30nMAssay Description:Binding affinity to recombinant human full length Cdc7 (1 to 574 residues)/human N-terminal GST-tagged ASK (1 to 674 residues) expressed in baculovir...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCell division cycle 7-related protein kinase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50253706(CHEMBL4083927)
Affinity DataKd:  0.541nMAssay Description:Inhibition of ATP-specific reporter probe binding to CDC7 (unknown origin) assessed as equilibrium dissociation constant incubated for 60 mins by pro...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCell division cycle 7-related protein kinase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50506351(CHEMBL4439133)
Affinity DataKd:  2nMAssay Description:Inhibition of ATP-specific reporter probe binding to CDC7 (unknown origin) assessed as equilibrium dissociation constant incubated for 60 mins by pro...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCell division cycle 7-related protein kinase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50506350(Simurosertib | Tak 931 | Tak-931)
Affinity DataKd:  0.424nMAssay Description:Binding affinity to CDC7 (unknown origin) assessed as equilibrium dissociation constantMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50506348(CHEMBL4436649)
Affinity DataIC50: 0.160nMAssay Description:Inhibition of N-terminal GST-fused full-length human CDC7 (1 to 574 end residues)/DBF4 (1 to 674 residues) expressed in baculovirus expression system...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50506358(CHEMBL4462898)
Affinity DataIC50: 0.160nMAssay Description:Inhibition of N-terminal GST-fused full-length human CDC7 (1 to 574 end residues)/DBF4 (1 to 674 residues) expressed in baculovirus expression system...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50506350(Simurosertib | Tak 931 | Tak-931)
Affinity DataIC50: 0.260nMAssay Description:Inhibition of N-terminal GST-fused full-length human CDC7 (1 to 574 end residues)/DBF4 (1 to 674 residues) expressed in baculovirus expression system...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50506351(CHEMBL4439133)
Affinity DataIC50: 0.410nMAssay Description:Inhibition of N-terminal GST-fused full-length human CDC7 (1 to 574 end residues)/DBF4 (1 to 674 residues) expressed in baculovirus expression system...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50506359(CHEMBL4570191)
Affinity DataIC50: 0.430nMAssay Description:Inhibition of N-terminal GST-fused full-length human CDC7 (1 to 574 end residues)/DBF4 (1 to 674 residues) expressed in baculovirus expression system...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50506351(CHEMBL4439133)
Affinity DataIC50: 0.440nMAssay Description:Inhibition of N-terminal GST-fused full-length human CDC7 (1 to 574 end residues)/DBF4 (1 to 674 residues) expressed in baculovirus expression system...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50506353(CHEMBL4543158)
Affinity DataIC50: 0.530nMAssay Description:Inhibition of N-terminal GST-fused full-length human CDC7 (1 to 574 end residues)/DBF4 (1 to 674 residues) expressed in baculovirus expression system...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50506350(Simurosertib | Tak 931 | Tak-931)
Affinity DataIC50: 0.540nMAssay Description:Inhibition of N-terminal GST-fused full-length human CDC7 (1 to 574 end residues)/DBF4 (1 to 674 residues) expressed in baculovirus expression system...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50237672(CHEMBL4089159)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of recombinant human Cdc7 (1 to 574 residues)/human N-terminal GST-tagged ASK (1 to 674 residues) expressed in baculovirus expression syst...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50506356(CHEMBL4569914)
Affinity DataIC50: 0.610nMAssay Description:Inhibition of N-terminal GST-fused full-length human CDC7 (1 to 574 end residues)/DBF4 (1 to 674 residues) expressed in baculovirus expression system...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50443648(CHEMBL3093076)
Affinity DataIC50: 0.690nMAssay Description:Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50253706(CHEMBL4083927)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of recombinant human full length Cdc7 (1 to 574 residues)/human N-terminal GST-tagged ASK (1 to 674 residues) expressed in baculovirus exp...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50253706(CHEMBL4083927)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of N-terminal GST-fused full-length human CDC7 (1 to 574 end residues)/DBF4 (1 to 674 residues) expressed in baculovirus expression system...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50506362(CHEMBL4440266)
Affinity DataIC50: 0.710nMAssay Description:Inhibition of N-terminal GST-fused full-length human CDC7 (1 to 574 end residues)/DBF4 (1 to 674 residues) expressed in baculovirus expression system...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50506359(CHEMBL4570191)
Affinity DataIC50: 0.720nMAssay Description:Inhibition of N-terminal GST-fused full-length human CDC7 (1 to 574 end residues)/DBF4 (1 to 674 residues) expressed in baculovirus expression system...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50443649(CHEMBL3093075)
Affinity DataIC50: 0.850nMAssay Description:Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50506347(CHEMBL4587191)
Affinity DataIC50: 0.910nMAssay Description:Inhibition of N-terminal GST-fused full-length human CDC7 (1 to 574 end residues)/DBF4 (1 to 674 residues) expressed in baculovirus expression system...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCell division cycle 7-related protein kinase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM123147(US8742113, 239)
Affinity DataIC50: 1nMpH: 7.5Assay Description:Measurement of kinase activity was carried out using an MSA assay kit (QuickScout Screening Assist Kit, Carna Biosciences, Inc.). Assay buffer (20 mM...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCell division cycle 7-related protein kinase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM123148(US8742113, 242)
Affinity DataIC50: 1nMpH: 7.5Assay Description:Measurement of kinase activity was carried out using an MSA assay kit (QuickScout Screening Assist Kit, Carna Biosciences, Inc.). Assay buffer (20 mM...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50443650(CHEMBL3093074)
Affinity DataIC50: 1nMAssay Description:Inhibition of Cdc7/Dbf4 (unknown origin)-mediated MCM2 phosphorylation at Ser53 by protein A amplified luminescent proximity homogeneous assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50380229(CHEMBL2016996)
Affinity DataIC50: 1nMAssay Description:Inhibition of CDC7/DBF4 using MCM-2 as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50380230(CHEMBL2016862)
Affinity DataIC50: 1nMAssay Description:Inhibition of CDC7/DBF4 using MCM-2 as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50380236(CHEMBL2016856)
Affinity DataIC50: 1nMAssay Description:Inhibition of CDC7/DBF4 using MCM-2 as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50450841(CHEMBL4214023)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human Cdc7 (1 to 574 residues)/human N-terminal GST-tagged DBF4 (1 to 674 residues) expressed in baculovirus expression sys...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50506361(CHEMBL4572218)
Affinity DataIC50: 1nMAssay Description:Inhibition of N-terminal GST-fused full-length human CDC7 (1 to 574 end residues)/DBF4 (1 to 674 residues) expressed in baculovirus expression system...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCell division cycle 7-related protein kinase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM636554(5-methyl-1-(pyridin-4-yl)- 4,6,7,8-tetrahydro-3H-9...)
Affinity DataIC50: 1nMAssay Description:Full length human CDC7 protein co-expressed with DBF4 was purchased from SignalChem (China). CDC7 kinase activity was determined with PDKtide (Signal...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCell division cycle 7-related protein kinase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM636555(6-methyl-2-(pyridin-4-yl)-5,7- dihydro-3-oxa-1-thi...)
Affinity DataIC50: 1nMAssay Description:Full length human CDC7 protein co-expressed with DBF4 was purchased from SignalChem (China). CDC7 kinase activity was determined with PDKtide (Signal...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCell division cycle 7-related protein kinase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM636583(6-methyl-2-(3-methyl-1H- pyrazol-4-yl)-5,7-dihydro...)
Affinity DataIC50: 1nMAssay Description:Full length human CDC7 protein co-expressed with DBF4 was purchased from SignalChem (China). CDC7 kinase activity was determined with PDKtide (Signal...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCell division cycle 7-related protein kinase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM636584(5-methyl-1-(1H-pyrazol-4-yl)- 4,6,7,8-tetrahydro-3...)
Affinity DataIC50: 1nMAssay Description:Full length human CDC7 protein co-expressed with DBF4 was purchased from SignalChem (China). CDC7 kinase activity was determined with PDKtide (Signal...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCell division cycle 7-related protein kinase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM636586((R)-4,6-dimethyl-2-(pyridin-4- yl)-5,7-dihydro-3-o...)
Affinity DataIC50: 1nMAssay Description:Full length human CDC7 protein co-expressed with DBF4 was purchased from SignalChem (China). CDC7 kinase activity was determined with PDKtide (Signal...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCell division cycle 7-related protein kinase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM636587((S)-4,6-dimethyl-2-(pyridin-4- yl)-5,7-dihydro-3-o...)
Affinity DataIC50: 1nMAssay Description:Full length human CDC7 protein co-expressed with DBF4 was purchased from SignalChem (China). CDC7 kinase activity was determined with PDKtide (Signal...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCell division cycle 7-related protein kinase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM636588(4,6-dimethyl-2-(1H-pyrazol-4- yl)-5,7-dihydro-3-ox...)
Affinity DataIC50: 1nMAssay Description:Full length human CDC7 protein co-expressed with DBF4 was purchased from SignalChem (China). CDC7 kinase activity was determined with PDKtide (Signal...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCell division cycle 7-related protein kinase(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM636590((S)-5-((3-hydroxypyrrolidin- 1-yl)methyl)-1-(1H-py...)
Affinity DataIC50: 1nMAssay Description:Full length human CDC7 protein co-expressed with DBF4 was purchased from SignalChem (China). CDC7 kinase activity was determined with PDKtide (Signal...More data for this Ligand-Target Pair
In DepthDetails
US Patent

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