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Report error Found 1777 Enz. Inhib. hit(s) with Target = 'Carboxylic ester hydrolase'
TargetCarboxylic ester hydrolase(Horse)
National Chung-Hsing University

Curated by ChEMBL
LigandPNGBDBM50450709(CHEMBL3084810)
Affinity DataKoff:  1.80E+3s-1Assay Description:Tested for kinetic data for the horse serum Butyrylcholinesterase-Catalyzed Hydrolysis of Butyrylthiocholine; 10e-3/M. secMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
National Chung-Hsing University

Curated by ChEMBL
LigandPNGBDBM50072037(Butyl-carbamic acid (S)-bicyclo[2.2.1]hept-2-yl es...)
Affinity DataKoff:  1.10E+5s-1Assay Description:Tested for kinetic data for the horse serum Butyrylcholinesterase-Catalyzed Hydrolysis of Butyrylthiocholine; 10e-3/M. secMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
National Chung-Hsing University

Curated by ChEMBL
LigandPNGBDBM50072039(Butyl-carbamic acid adamantan-1-yl ester | CHEMBL9...)
Affinity DataKoff:  1.90E+3s-1Assay Description:Tested for kinetic data for the horse serum Butyrylcholinesterase-Catalyzed Hydrolysis of Butyrylthiocholine; 10e-3/M. secMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
National Chung-Hsing University

Curated by ChEMBL
LigandPNGBDBM50072037(Butyl-carbamic acid (S)-bicyclo[2.2.1]hept-2-yl es...)
Affinity DataKoff:  2.20E+3s-1Assay Description:Tested for kinetic data for the horse serum Butyrylcholinesterase-Catalyzed Hydrolysis of Butyrylthiocholine; 10e-3/M. secMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
National Chung-Hsing University

Curated by ChEMBL
LigandPNGBDBM8961(CHEMBL95 | Cognex | cid_1935 | CHEMBL1337960 | 1,2...)
Affinity DataIC50: 0.0244nMAssay Description:Enzyme activity using acetylcholinesterase (AChE) and butyrylcholinesterase (BChE).More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCarboxylic ester hydrolase(Fruit fly)
University of California

Curated by ChEMBL
LigandPNGBDBM50409669(CHEMBL155514)
Affinity DataIC50: 0.537nMAssay Description:In vitro inhibition of Trichoplusia Juvenile Hormone Esterase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
National Chung-Hsing University

Curated by ChEMBL
LigandPNGBDBM86769(Nicotinamide hydrochloride analog, 6b)
Affinity DataIC50: 0.645nMAssay Description:Enzyme activity using acetylcholinesterase (AChE) and butyrylcholinesterase (BChE).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
National Chung-Hsing University

Curated by ChEMBL
LigandPNGBDBM8986(7-chloro-1,2,3,4-tetrahydroacridin-9-amine | Tacri...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of (BChE) Butyrylcholinesterase of horse serumMore data for this Ligand-Target Pair
In DepthDetails Article

TargetCarboxylic ester hydrolase(House fly)
University of Missouri-St. Louis

Curated by ChEMBL
LigandPNGBDBM50308520(cyclophostin | CHEMBL603622)
Affinity DataIC50: 0.760nMAssay Description:Inhibition of housefly CSMA AChEMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarboxylic ester hydrolase(Pig)
Guru Nanak Dev University

Curated by ChEMBL
LigandPNGBDBM50235214(CHEMBL4084903)
Affinity DataIC50: 0.780nMAssay Description:Inhibition of porcine cholesterol esterase using para-nitrophenyl butyrate as substrate after 5 mins in presence of sodium taurocholate by spectropho...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
National Chung-Hsing University

Curated by ChEMBL
LigandPNGBDBM86771(Nicotinamide hydrochloride analog, 6d)
Affinity DataIC50: 0.811nMAssay Description:Enzyme activity using acetylcholinesterase (AChE) and butyrylcholinesterase (BChE).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
National Chung-Hsing University

Curated by ChEMBL
LigandPNGBDBM9007(7-(1,2,3,4-Tetrahydro-acridin-9-ylamino)-heptanoic...)
Affinity DataIC50: 0.950nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
National Chung-Hsing University

Curated by ChEMBL
LigandPNGBDBM227587(3-fluoro-N-[4-(1,2,3,4-tetrahydroacridin-9-ylamino...)
Affinity DataIC50: 1.02nMpH: 7.4 T: 2°CAssay Description:The test was run as described in the following procedure: stock solution of the test compounds was diluted in phosphate buffer pH 7.4 to give final c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
National Chung-Hsing University

Curated by ChEMBL
LigandPNGBDBM86770(Nicotinamide hydrochloride analog, 6c)
Affinity DataIC50: 1.13nMAssay Description:Enzyme activity using acetylcholinesterase (AChE) and butyrylcholinesterase (BChE).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
National Chung-Hsing University

Curated by ChEMBL
LigandPNGBDBM50060470(10-azoniatetracyclo[10.2.1.02,11.04,9]pentadeca-2,...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of (BChE) Butyrylcholinesterase of horse serumMore data for this Ligand-Target Pair
In DepthDetails Article

TargetCarboxylic ester hydrolase(Horse)
National Chung-Hsing University

Curated by ChEMBL
LigandPNGBDBM227584(2-Fluoro-N-[4-(1,2,3,4-tetrahydroacridin-9-ylamino...)
Affinity DataIC50: 1.39nMpH: 7.4 T: 2°CAssay Description:The test was run as described in the following procedure: stock solution of the test compounds was diluted in phosphate buffer pH 7.4 to give final c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
National Chung-Hsing University

Curated by ChEMBL
LigandPNGBDBM9426(N-9-(1,2,3,4-Tetrahydroacridinyl)-1,8-diamino-octa...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of equine BChE by Ellman's assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarboxylic ester hydrolase(Pig)
Guru Nanak Dev University

Curated by ChEMBL
LigandPNGBDBM50235213(CHEMBL4102852)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of porcine cholesterol esterase using para-nitrophenyl butyrate as substrate after 5 mins in presence of sodium taurocholate by spectropho...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
National Chung-Hsing University

Curated by ChEMBL
LigandPNGBDBM86768(Nicotinamide hydrochloride analog, 6a)
Affinity DataIC50: 1.45nMAssay Description:Enzyme activity using acetylcholinesterase (AChE) and butyrylcholinesterase (BChE).More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
National Chung-Hsing University

Curated by ChEMBL
LigandPNGBDBM9013(6-(1,2,3,4-Tetrahydro-acridin-9-ylamino)-hexanoic ...)
Affinity DataIC50: 2nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarboxylic ester hydrolase(Pig)
Guru Nanak Dev University

Curated by ChEMBL
LigandPNGBDBM50235212(CHEMBL4092661)
Affinity DataIC50: 2nMAssay Description:Inhibition of porcine cholesterol esterase using para-nitrophenyl butyrate as substrate after 5 mins in presence of sodium taurocholate by spectropho...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
National Chung-Hsing University

Curated by ChEMBL
LigandPNGBDBM9014(N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-7-(1,2,3,4-te...)
Affinity DataIC50: 2.5nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
National Chung-Hsing University

Curated by ChEMBL
LigandPNGBDBM50333767(N1-(1,2,3,4-Tetrahydroacridin-9-yl)-N6-(3,4,5-trim...)
Affinity DataIC50: 2.59nMAssay Description:Inhibition of equine BChE by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
National Chung-Hsing University

Curated by ChEMBL
LigandPNGBDBM50333763(N1-(3,4-Dimethoxybenzyl)-N6-(1,2,3,4-tetrahydroacr...)
Affinity DataIC50: 2.68nMAssay Description:Inhibition of equine BChE by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarboxylic ester hydrolase(Rat)
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50235800(CHEBI:553827 | Bambuterol)
Affinity DataIC50: 3nMAssay Description:Inhibition of rat BChEMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetCarboxylic ester hydrolase(Pig)
Guru Nanak Dev University

Curated by ChEMBL
LigandPNGBDBM50159614(2-(2-Fluoro-phenyl)-benzo[h]chromen-4-one | CHEMBL...)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of porcine cholesterol esterase using para-nitrophenyl butyrate as substrate after 5 mins in presence of sodium taurocholate by spectropho...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
National Chung-Hsing University

Curated by ChEMBL
LigandPNGBDBM50333765(N1-(1,2,3,4-Tetrahydroacridin-9-yl)-N8-(3,4,5-trim...)
Affinity DataIC50: 3.38nMAssay Description:Inhibition of equine BChE by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
National Chung-Hsing University

Curated by ChEMBL
LigandPNGBDBM9018(N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-6-(1,2,3,4-te...)
Affinity DataIC50: 3.5nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
National Chung-Hsing University

Curated by ChEMBL
LigandPNGBDBM50333766(N1-(1,2,3,4-Tetrahydroacridin-9-yl)-N7-(3,4,5-trim...)
Affinity DataIC50: 3.55nMAssay Description:Inhibition of equine BChE by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
National Chung-Hsing University

Curated by ChEMBL
LigandPNGBDBM227586(3-Fluoro-N-[3-(1,2,3,4-tetrahydroacridin-9-ylamino...)
Affinity DataIC50: 3.79nMpH: 7.4 T: 2°CAssay Description:The test was run as described in the following procedure: stock solution of the test compounds was diluted in phosphate buffer pH 7.4 to give final c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
National Chung-Hsing University

Curated by ChEMBL
LigandPNGBDBM50333764(N1-(1,2,3,4-Tetrahydroacridin-9-yl)-N9-(3,4,5-trim...)
Affinity DataIC50: 4.73nMAssay Description:Inhibition of equine BChE by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
National Chung-Hsing University

Curated by ChEMBL
LigandPNGBDBM227585(3-Fluoro-N-[2-(1,2,3,4-tetrahydroacridin-9-ylamino...)
Affinity DataIC50: 4.76nMpH: 7.4 T: 2°CAssay Description:The test was run as described in the following procedure: stock solution of the test compounds was diluted in phosphate buffer pH 7.4 to give final c...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
National Chung-Hsing University

Curated by ChEMBL
LigandPNGBDBM50194097(N,N'-bis[2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)...)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of horse serum BChEMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
National Chung-Hsing University

Curated by ChEMBL
LigandPNGBDBM50377432(CHEMBL258927)
Affinity DataIC50: 5nMAssay Description:Inhibition of equine BChE by Ellman's assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
National Chung-Hsing University

Curated by ChEMBL
LigandPNGBDBM8961(CHEMBL95 | Cognex | cid_1935 | CHEMBL1337960 | 1,2...)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of BuChE from equine serumMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCarboxylic ester hydrolase(Horse)
National Chung-Hsing University

Curated by ChEMBL
LigandPNGBDBM8961(CHEMBL95 | Cognex | cid_1935 | CHEMBL1337960 | 1,2...)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of equine BChE by Ellman's assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCarboxylic ester hydrolase(Horse)
National Chung-Hsing University

Curated by ChEMBL
LigandPNGBDBM50333771(N1-((7-Methoxybenzo[d][1,3]dioxol-5-yl)methyl)-N6-...)
Affinity DataIC50: 5.19nMAssay Description:Inhibition of equine BChE by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
National Chung-Hsing University

Curated by ChEMBL
LigandPNGBDBM9008(6-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]...)
Affinity DataIC50: 5.20nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
National Chung-Hsing University

Curated by ChEMBL
LigandPNGBDBM8961(CHEMBL95 | Cognex | cid_1935 | CHEMBL1337960 | 1,2...)
Affinity DataIC50: 5.20nMpH: 8.0Assay Description:The inhibitory activity of the enzyme acetylcholinesterase (AChE) was evaluated by the Ellman method (Biochem. Pharmacol. 1961, 7, 88) using an elect...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
TargetCarboxylic ester hydrolase(Horse)
National Chung-Hsing University

Curated by ChEMBL
LigandPNGBDBM8961(CHEMBL95 | Cognex | cid_1935 | CHEMBL1337960 | 1,2...)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of (BChE) Butyrylcholinesterase of horse serumMore data for this Ligand-Target Pair
In DepthDetails Article
PDB3D3D Structure (crystal)
TargetCarboxylic ester hydrolase(Horse)
National Chung-Hsing University

Curated by ChEMBL
LigandPNGBDBM8961(CHEMBL95 | Cognex | cid_1935 | CHEMBL1337960 | 1,2...)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate after 15 mins by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetCarboxylic ester hydrolase(Pig)
Guru Nanak Dev University

Curated by ChEMBL
LigandPNGBDBM50159673(2-(3-Fluoro-phenyl)-benzo[h]chromen-4-one | CHEMBL...)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of porcine cholesterol esterase using para-nitrophenyl butyrate as substrate after 5 mins in presence of sodium taurocholate by spectropho...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarboxylic ester hydrolase(Fruit fly)
University of California

Curated by ChEMBL
LigandPNGBDBM50409657(CHEMBL153015)
Affinity DataIC50: 5.25nMAssay Description:In vitro inhibition of Trichoplusia Juvenile Hormone Esterase.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
National Chung-Hsing University

Curated by ChEMBL
LigandPNGBDBM50377431(CHEMBL258744)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of equine BChE by Ellman's assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
National Chung-Hsing University

Curated by ChEMBL
LigandPNGBDBM50333762(N1-(3,4-Dimethoxybenzyl)-N7-(1,2,3,4-tetrahydroacr...)
Affinity DataIC50: 5.51nMAssay Description:Inhibition of equine BChE by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
National Chung-Hsing University

Curated by ChEMBL
LigandPNGBDBM50333761(N1-(3,4-Dimethoxybenzyl)-N8-(1,2,3,4-tetrahydroacr...)
Affinity DataIC50: 5.57nMAssay Description:Inhibition of equine BChE by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
National Chung-Hsing University

Curated by ChEMBL
LigandPNGBDBM50333760(N1-(3,4-Dimethoxybenzyl)-N9-(1,2,3,4-tetrahydroacr...)
Affinity DataIC50: 5.67nMAssay Description:Inhibition of equine BChE by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
National Chung-Hsing University

Curated by ChEMBL
LigandPNGBDBM50261344(N-(3-{[6-Chloro-2,3-dihydropyrrolo[2,1-b]quinazoli...)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of equine serum BuChE by Ellman's assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarboxylic ester hydrolase(Rat)
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50014107(CHEMBL74950 | 1,3alpha,8-trimethyl-1,2,3,3alpha,8,...)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of rat plasma BChE by Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCarboxylic ester hydrolase(Horse)
National Chung-Hsing University

Curated by ChEMBL
LigandPNGBDBM8961(CHEMBL95 | Cognex | cid_1935 | CHEMBL1337960 | 1,2...)
Affinity DataIC50: 5.90nMpH: 8.0 T: 2°CAssay Description:This spectrophotometric assay is based on the reaction of 5,5-dithio-bis(2-nitrobenzoic)acid (DTNB) with thiocholine to yield a colored product. Shim...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
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