BDBM50457825 CHEMBL4207042

SMILES CNC(=O)c1cnc(N)c(O[C@H]2CN(CC2(F)F)C(=O)Cc2ccc(OC(F)(F)F)cc2)c1

InChI Key InChIKey=FTAFQADCGCSJAH-UHFFFAOYSA-N

Data  5 IC50  2 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50457825   

TargetNT-3 growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50457825(CHEMBL4207042)
Affinity DataIC50: 2.20nMAssay Description:Antagonist activity at prolink-tagged TrkC in human U2OS cells assessed as inhibition of NT3-induced receptor phosphorylation by measuring reduction ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50457825(CHEMBL4207042)
Affinity DataKd:  2.30nMAssay Description:Binding affinity to un phosphorylated C-terminal His6/N-terminal BAP-tagged TrkA (441 to 796 residues) (unknown origin) by SPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50457825(CHEMBL4207042)
Affinity DataIC50: 8.40nMAssay Description:Antagonist activity at prolink-tagged TrkA in human U2OS cells assessed as inhibition of beta-NGF-induced receptor phosphorylation by measuring reduc...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetBDNF/NT-3 growth factors receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50457825(CHEMBL4207042)
Affinity DataIC50: 6.20nMAssay Description:Antagonist activity at prolink-tagged TrkB in human U2OS cells assessed as inhibition of BDNF-induced receptor phosphorylation by measuring reduction...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50457825(CHEMBL4207042)
Affinity DataIC50: 8.80E+4nMAssay Description:Inhibition of human ERG by patch express assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50457825(CHEMBL4207042)
Affinity DataKd:  5.70nMAssay Description:Binding affinity to un phosphorylated C-terminal His6/N-terminal BAP-tagged TrkA (441 to 796 residues) (unknown origin) assessed as dissociation rate...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50457825(CHEMBL4207042)
Affinity DataIC50: 7.90E+4nMAssay Description:Inhibition of human ERG by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed