BDBM50449710 CHEMBL4170094

SMILES Cc1cc(C)nc(SCC(=O)Nc2cccc(COc3ccc(NC(=O)c4cnn(C)c4)cc3)c2)n1

InChI Key InChIKey=NPUWKDPBMLZNJM-UHFFFAOYSA-N

Data  7 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50449710   

TargetNAD-dependent protein deacetylase sirtuin-1(Human)
West China School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50449710(CHEMBL4170094)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged SIRT1 (241 to 512 residues) expressed in Escherichia coli Transetta(DE3) using AcIQF as substr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-5, mitochondrial(Human)
West China School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50449710(CHEMBL4170094)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged SIRT5 (34 to 356 residues) expressed in Escherichia coli Transetta(DE3) using GluIQF as substr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNAD-dependent protein deacylase sirtuin-6(Human)
West China School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50449710(CHEMBL4170094)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged SIRT6 (4 to 296 residues) expressed in Escherichia coli Transetta(DE3) using AcIQF as substrat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-7(Human)
West China School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50449710(CHEMBL4170094)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged SIRT7 (68 to 354 residues) expressed in Escherichia coli Transetta(DE3) using AcIQF as substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
West China School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50449710(CHEMBL4170094)
Affinity DataIC50: 813nMAssay Description:Inhibition of recombinant His-tagged SIRT2 (56 to 356 residues) (unknown origin) expressed in Escherichia coli Transetta(DE3) using AcIQF as substrat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetNAD-dependent protein deacetylase sirtuin-2(Human)
West China School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50449710(CHEMBL4170094)
Affinity DataIC50: 815nMAssay Description:Inhibition of recombinant His-tagged SIRT2 (56 to 356 residues) (unknown origin) expressed in Escherichia coli Transetta(DE3) using AcIQF as substrat...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Human)
West China School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50449710(CHEMBL4170094)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged SIRT3 (122 to 391 residues) expressed in Escherichia coli Transetta(DE3) using AcIQF as substr...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed