BDBM50012899 (Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid::CHEMBL15770::SULINDAC::cis-5-Fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid::cis-5-Fluoro-2-methyl-1-((p-methylsulfinyl)benzylidene)indene-3-acetic acid::{(1Z)-5-fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]-1H-inden-3-yl}acetic acid

SMILES CC1=C(CC(O)=O)c2cc(F)ccc2\C1=C/c1ccc(cc1)S(C)=O

InChI Key InChIKey=MLKXDPUZXIRXEP-UHFFFAOYSA-N

Data  2 KI  5 IC50  1 EC50

PDB links: 10 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50012899   

TargetAldo-keto reductase family 1 member B1 [K65Q](Bovine)
Comsats Institute of Information Technology

LigandPNGBDBM50012899(cis-5-Fluoro-2-methyl-1-((p-methylsulfinyl)benzyli...)
Affinity DataIC50: 293nMAssay Description:The activity of ALR2 enzyme was determined at 340 nm in UV spectrophotometer that depends upon the measurement of NADPH consumption. Each well of the...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member B10 [K125R,V301L](Human)
Institut De Ge��Ne��Tique Et De Biologie Mole��Culaire Et Cellulaire

LigandPNGBDBM50012899(cis-5-Fluoro-2-methyl-1-((p-methylsulfinyl)benzyli...)
Affinity DataIC50: 2.69E+3nMpH: 7.0Assay Description:The IC50-activity assays were carried out on the basis of the quantification of the NADPH consumption that takes place when the enzyme catalyzes the ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50012899(cis-5-Fluoro-2-methyl-1-((p-methylsulfinyl)benzyli...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of 5-lipoxygenase in intact RBL-1 cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetGlycine receptor subunit alpha-1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandPNGBDBM50012899(cis-5-Fluoro-2-methyl-1-((p-methylsulfinyl)benzyli...)
Affinity DataEC50:  380nMAssay Description:Potentiation of human GlyR-alpha1 expressed in Xenopus laevis oocytes assessed as induction of glycine-activated currents after 1 to 4 days by two-el...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin E synthase(Human)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50012899(cis-5-Fluoro-2-methyl-1-((p-methylsulfinyl)benzyli...)
Affinity DataIC50: 8.00E+4nMAssay Description:Inhibition of microsomal PGESMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRetinoic acid receptor RXR-alpha(Human)
Xiamen University

Curated by ChEMBL
LigandPNGBDBM50012899(cis-5-Fluoro-2-methyl-1-((p-methylsulfinyl)benzyli...)
Affinity DataIC50: 8.29E+4nMAssay Description:Displacement of [3H]-9-cis-RA from RXRalpha (unknown origin) by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLactoylglutathione lyase(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50012899(cis-5-Fluoro-2-methyl-1-((p-methylsulfinyl)benzyli...)
Affinity DataKi:  7.79E+4nMAssay Description:Inhibition of glyoxalase 1More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetLactoylglutathione lyase(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50012899(cis-5-Fluoro-2-methyl-1-((p-methylsulfinyl)benzyli...)
Affinity DataKi:  1.39E+5nMAssay Description:Inhibition of human recombinant His-tagged glyoxalase 1 expressed in Escherichia coli BL21 (DE3) preincubated for 20 mins by Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed