BDBM50000663 (+)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]hexadeca-2(7),3,5,10(15),11,13-hexaene::(+)-MK-801::(+)MK-801::(+/-) MK-8011-methyl-(9R,1R)-16-azatetracyclo[7.6.1.02,7.010,15]hexadeca-2(7),3,5,10(15),11,13-hexaene::(+/-)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]hexadeca-2(7),3,5,10(15),11,13-hexaene::(+/-)-MK801::(-)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]hexadeca-2(7),3,5,10(15),11,13-hexaene::(-)-MK801::(1S,9R)-1-methyl-16-azatetracyclo[7.6.1.0^{2,7}.0^{10,15}]hexadeca-2(7),3,5,10(15),11,13-hexaene::(1S,9R)-1-methyl-16-azatetracyclo[7.6.1.0^{2,7}.0^{10,15}]hexadeca-2,4,6,10(15),11,13-hexaene::(5S,10R)-(+)-5-methyl-10,11-dihydro-5Hdibenzo[a,d]cyclohepten-5,10-imine::(5S,10S)-(+)-5-methyl-10,11-dihydro-5Hdibenzo[a,d]cyclohepten-5,10-imine::(Dizocilpine)1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]hexadeca-2(7),3,5,10(15),11,13-hexaene::(MK-801)1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]hexadeca-2(7),3,5,10(15),11,13-hexaene::1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]hexadeca-2(7),3,5,10(15),11,13-hexaene::1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]hexadeca-2(7),3,5,10(15),11,13-hexaene(MK-801)::1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]hexadeca-2(7),3,5,10,12,14-hexaene::1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]hexadeca-2,4,6,10(15),11,13-hexaene::10,11-Dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine.(MK-801)::CHEMBL284237::MK-801::MK-801 (Dizocilpine)::MK-801,(+)::MK-801,(-)::US11944616, Compound Dizocilpine::dizocilpine

SMILES C[C@]12NC(Cc3ccccc13)c1ccccc21

InChI Key InChIKey=LBOJYSIDWZQNJS-UHFFFAOYSA-N

Data  16 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50000663   

TargetGlutamate receptor ionotropic, NMDA 1(Rat)
Institut National De La Sante Et De La Recherche Medicale (Inserm

US Patent
LigandPNGBDBM50000663((5S,10S)-(+)-5-methyl-10,11-dihydro-5Hdibenzo[a,d]...)
Affinity DataIC50: 290nMAssay Description:In Vitro Activity: Evaluation of NMDAR Blocking Activity Using Patch-ClampPrevious studies have shown that the NMDAR exists in the peripheral vascula...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2024
Entry Details
Go to US Patent

TargetGlutamate receptor ionotropic, NMDA 1(Human)
Medical University of Lublin

Curated by ChEMBL
LigandPNGBDBM50000663((5S,10S)-(+)-5-methyl-10,11-dihydro-5Hdibenzo[a,d]...)
Affinity DataIC50: 9nMpH: 6.9Assay Description:Antagonist activity at NR1/2B receptor expressed in xenopus laevis at pH 6.9 by two electrode voltage clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
Institut National De La Sante Et De La Recherche Medicale (Inserm

US Patent
LigandPNGBDBM50000663((5S,10S)-(+)-5-methyl-10,11-dihydro-5Hdibenzo[a,d]...)
Affinity DataKi:  2.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2011
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
Institut National De La Sante Et De La Recherche Medicale (Inserm

US Patent
LigandPNGBDBM50000663((5S,10S)-(+)-5-methyl-10,11-dihydro-5Hdibenzo[a,d]...)
Affinity DataKi:  6.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2011
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
Institut National De La Sante Et De La Recherche Medicale (Inserm

US Patent
LigandPNGBDBM50000663((5S,10S)-(+)-5-methyl-10,11-dihydro-5Hdibenzo[a,d]...)
Affinity DataKi:  8.40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2011
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
Institut National De La Sante Et De La Recherche Medicale (Inserm

US Patent
LigandPNGBDBM50000663((5S,10S)-(+)-5-methyl-10,11-dihydro-5Hdibenzo[a,d]...)
Affinity DataKi:  8.90nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2011
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
Institut National De La Sante Et De La Recherche Medicale (Inserm

US Patent
LigandPNGBDBM50000663((5S,10S)-(+)-5-methyl-10,11-dihydro-5Hdibenzo[a,d]...)
Affinity DataKi:  9.40nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2011
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
Institut National De La Sante Et De La Recherche Medicale (Inserm

US Patent
LigandPNGBDBM50000663((5S,10S)-(+)-5-methyl-10,11-dihydro-5Hdibenzo[a,d]...)
Affinity DataKi:  10.8nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2011
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
Institut National De La Sante Et De La Recherche Medicale (Inserm

US Patent
LigandPNGBDBM50000663((5S,10S)-(+)-5-methyl-10,11-dihydro-5Hdibenzo[a,d]...)
Affinity DataKi:  13.7nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2011
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
Institut National De La Sante Et De La Recherche Medicale (Inserm

US Patent
LigandPNGBDBM50000663((5S,10S)-(+)-5-methyl-10,11-dihydro-5Hdibenzo[a,d]...)
Affinity DataKi:  20.4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2011
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
Institut National De La Sante Et De La Recherche Medicale (Inserm

US Patent
LigandPNGBDBM50000663((5S,10S)-(+)-5-methyl-10,11-dihydro-5Hdibenzo[a,d]...)
Affinity DataKi:  24.9nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2011
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
Institut National De La Sante Et De La Recherche Medicale (Inserm

US Patent
LigandPNGBDBM50000663((5S,10S)-(+)-5-methyl-10,11-dihydro-5Hdibenzo[a,d]...)
Affinity DataKi:  27.2nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2011
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1(Rat)
Institut National De La Sante Et De La Recherche Medicale (Inserm

US Patent
LigandPNGBDBM50000663((5S,10S)-(+)-5-methyl-10,11-dihydro-5Hdibenzo[a,d]...)
Affinity DataKi:  53.7nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2011
Entry Details Article
PubMed
TargetNischarin(Rat)
University of Bonn

Curated by PDSP Ki Database
LigandPNGBDBM50000663((5S,10S)-(+)-5-methyl-10,11-dihydro-5Hdibenzo[a,d]...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50000663((5S,10S)-(+)-5-methyl-10,11-dihydro-5Hdibenzo[a,d]...)
Affinity DataKi:  4.09E+4nMAssay Description:Tested for in vitro inhibition of the displacement of [3H]mazindol from GABA receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50000663((5S,10S)-(+)-5-methyl-10,11-dihydro-5Hdibenzo[a,d]...)
Affinity DataKi:  5.92E+4nMAssay Description:Tested for in vitro inhibition of the displacement of (+)-[3H]pentazocine from sigma opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50000663((5S,10S)-(+)-5-methyl-10,11-dihydro-5Hdibenzo[a,d]...)
Affinity DataKi: >1.00E+5nMAssay Description:Tested for in vitro inhibition of the displacement of [3H]FOXY from mu opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50000663((5S,10S)-(+)-5-methyl-10,11-dihydro-5Hdibenzo[a,d]...)
Affinity DataKi: >1.00E+5nMAssay Description:Tested for in vitro inhibition of the displacement of [3H]QNB from CNS receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed