| Assay Method Information | |
| | In Vitro Activity Assay |
| Description: | In Vitro Activity: Evaluation of NMDAR Blocking Activity Using Patch-ClampPrevious studies have shown that the NMDAR exists in the peripheral vasculature.All NMDAR subunits were examined by RT-PCR and sequencing in the peripheral endothelium and peripheral vascular smooth muscle cells. The sequences of these NMDAR subunits in both vascular cells showed a high similarity if not identity to the sequences of brain NMDAR (Chen H et al, J Vasc Surg 2005, Qureshi I et al Vasc Med 2005).The molecules described herein were tested in serial concentrations ranging from 1 nM to 100 μM for their NMDAR blocking activity using patch-clamp. |
| Affinity data for this assay | |
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