BDBM50001765 8-chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine::CHEMBL646::Halcion::TRIAZOLAM::US20240190889, Example Triazolam::US20240270744, Example Triazolam
SMILES Cc1nnc2CN=C(c3ccccc3Cl)c3cc(Cl)ccc3-n12
InChI Key InChIKey=JOFWLTCLBGQGBO-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 28 hits for monomerid = 50001765
Affinity DataKd: 1nMAssay Description:Binding affinity to GABAA alpha-1-beta-2-gamma-2 receptorMore data for this Ligand-Target Pair
Affinity DataKd: 4nMAssay Description:Binding affinity to GABAA alpha-5-beta-2-gamma-2 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 1.11E+4nMAssay Description:Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaMore data for this Ligand-Target Pair
TargetCholecystokinin receptor type A(Rat)
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 3.90E+4nMAssay Description:Displacement of [125I]CCK from Cholecystokinin receptor of rat pancreasMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Human)
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Displacement of [125I]gastrin from guinea pig gastric glandsMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Neurocrine Biosciences
Curated by PDSP Ki Database
Neurocrine Biosciences
Curated by PDSP Ki Database
TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Neurocrine Biosciences
Curated by PDSP Ki Database
Neurocrine Biosciences
Curated by PDSP Ki Database
TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Neurocrine Biosciences
Curated by PDSP Ki Database
Neurocrine Biosciences
Curated by PDSP Ki Database
TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Neurocrine Biosciences
Curated by PDSP Ki Database
Neurocrine Biosciences
Curated by PDSP Ki Database
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee
Curated by ChEMBL
University of Wisconsin-Milwaukee
Curated by ChEMBL
Affinity DataKi: 0.590nMAssay Description:Binding affinity to human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-2-beta-3-gamma-2More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee
Curated by ChEMBL
University of Wisconsin-Milwaukee
Curated by ChEMBL
Affinity DataKi: 0.800nMAssay Description:Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-1-beta-3-gamma-2More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
Merck Sharp & Dohme Research Laboratories
Curated by PDSP Ki Database
Merck Sharp & Dohme Research Laboratories
Curated by PDSP Ki Database
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee
Curated by ChEMBL
University of Wisconsin-Milwaukee
Curated by ChEMBL
Affinity DataKi: 1.40nMAssay Description:Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-3-beta-3-gamma-2More data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee
Curated by ChEMBL
University of Wisconsin-Milwaukee
Curated by ChEMBL
Affinity DataKi: 1.5nMAssay Description:Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-5-beta-3-gamma-2More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee
Curated by ChEMBL
University of Wisconsin-Milwaukee
Curated by ChEMBL
Affinity DataKi: 1.5nMAssay Description:The affinity of compounds at GABAA γ2 subunit-containing receptors was measured by competition for [3H]Flumazenil (81.1 Ci/mmol; Roche) binding ...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-1(Human)
Hoffmann-La Roche
US Patent
Hoffmann-La Roche
US Patent
Affinity DataKi: 1.5nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-3(Human)
Merck Sharp & Dohme Research Laboratories
Curated by PDSP Ki Database
Merck Sharp & Dohme Research Laboratories
Curated by PDSP Ki Database
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-1(Human)
Hoffmann-La Roche
US Patent
Hoffmann-La Roche
US Patent
Affinity DataKi: 44.2nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee
Curated by ChEMBL
University of Wisconsin-Milwaukee
Curated by ChEMBL
Affinity DataKi: 44.2nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-1(Human)
Hoffmann-La Roche
US Patent
Hoffmann-La Roche
US Patent
Affinity DataKi: 46.2nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-1(Human)
Hoffmann-La Roche
US Patent
Hoffmann-La Roche
US Patent
Affinity DataKi: 46.2nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee
Curated by ChEMBL
University of Wisconsin-Milwaukee
Curated by ChEMBL
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-6-beta-3-gamma-2More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-6(Human)
Merck Sharp & Dohme Research Laboratories
Curated by PDSP Ki Database
Merck Sharp & Dohme Research Laboratories
Curated by PDSP Ki Database