BDBM50001765 8-chloro-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine::CHEMBL646::Halcion::TRIAZOLAM::US20240190889, Example Triazolam::US20240270744, Example Triazolam

SMILES Cc1nnc2CN=C(c3ccccc3Cl)c3cc(Cl)ccc3-n12

InChI Key InChIKey=JOFWLTCLBGQGBO-UHFFFAOYSA-N

Data  23 KI  3 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 28 hits for monomerid = 50001765   

LigandPNGBDBM50001765(Halcion | CHEMBL646 | 8-chloro-6-(2-chlorophenyl)-...)
Affinity DataKd:  1nMAssay Description:Binding affinity to GABAA alpha-1-beta-2-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
LigandPNGBDBM50001765(Halcion | CHEMBL646 | 8-chloro-6-(2-chlorophenyl)-...)
Affinity DataKd:  4nMAssay Description:Binding affinity to GABAA alpha-5-beta-2-gamma-2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetPlatelet-activating factor receptor(Guinea pig)
American Cyanamid

Curated by ChEMBL
LigandPNGBDBM50001765(Halcion | CHEMBL646 | 8-chloro-6-(2-chlorophenyl)-...)
Affinity DataIC50: 1.11E+4nMAssay Description:Inhibition of PAF-induced platelet aggregation in rabbit platelet rich plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50001765(Halcion | CHEMBL646 | 8-chloro-6-(2-chlorophenyl)-...)
Affinity DataIC50: 3.90E+4nMAssay Description:Displacement of [125I]CCK from Cholecystokinin receptor of rat pancreasMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50001765(Halcion | CHEMBL646 | 8-chloro-6-(2-chlorophenyl)-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Displacement of [125I]gastrin from guinea pig gastric glandsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Neurocrine Biosciences

Curated by PDSP Ki Database
LigandPNGBDBM50001765(Halcion | CHEMBL646 | 8-chloro-6-(2-chlorophenyl)-...)
Affinity DataKi:  0.310nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2012
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Neurocrine Biosciences

Curated by PDSP Ki Database
LigandPNGBDBM50001765(Halcion | CHEMBL646 | 8-chloro-6-(2-chlorophenyl)-...)
Affinity DataKi:  0.340nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2012
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Neurocrine Biosciences

Curated by PDSP Ki Database
LigandPNGBDBM50001765(Halcion | CHEMBL646 | 8-chloro-6-(2-chlorophenyl)-...)
Affinity DataKi:  0.450nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2012
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Rat)
Neurocrine Biosciences

Curated by PDSP Ki Database
LigandPNGBDBM50001765(Halcion | CHEMBL646 | 8-chloro-6-(2-chlorophenyl)-...)
Affinity DataKi:  0.550nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2012
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50001765(Halcion | CHEMBL646 | 8-chloro-6-(2-chlorophenyl)-...)
Affinity DataKi:  0.590nMAssay Description:Binding affinity to human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-2-beta-3-gamma-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
LigandPNGBDBM50001765(Halcion | CHEMBL646 | 8-chloro-6-(2-chlorophenyl)-...)
Affinity DataKi:  0.680nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2012
Entry Details
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50001765(Halcion | CHEMBL646 | 8-chloro-6-(2-chlorophenyl)-...)
Affinity DataKi:  0.800nMAssay Description:Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-1-beta-3-gamma-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50001765(Halcion | CHEMBL646 | 8-chloro-6-(2-chlorophenyl)-...)
Affinity DataKi:  1.20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2012
Entry Details
PubMed
LigandPNGBDBM50001765(Halcion | CHEMBL646 | 8-chloro-6-(2-chlorophenyl)-...)
Affinity DataKi:  1.20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2012
Entry Details
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50001765(Halcion | CHEMBL646 | 8-chloro-6-(2-chlorophenyl)-...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-3-beta-3-gamma-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50001765(Halcion | CHEMBL646 | 8-chloro-6-(2-chlorophenyl)-...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-5-beta-3-gamma-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50001765(Halcion | CHEMBL646 | 8-chloro-6-(2-chlorophenyl)-...)
Affinity DataKi:  1.5nMAssay Description:The affinity of compounds at GABAA γ2 subunit-containing receptors was measured by competition for [3H]Flumazenil (81.1 Ci/mmol; Roche) binding ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent

LigandPNGBDBM50001765(Halcion | CHEMBL646 | 8-chloro-6-(2-chlorophenyl)-...)
Affinity DataKi:  1.5nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2024
Entry Details
Go to US Patent

LigandPNGBDBM50001765(Halcion | CHEMBL646 | 8-chloro-6-(2-chlorophenyl)-...)
Affinity DataKi:  1.80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2012
Entry Details
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3(Human)
Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50001765(Halcion | CHEMBL646 | 8-chloro-6-(2-chlorophenyl)-...)
In Depth
Date in BDB:
2/9/2012
Entry Details
PubMed
LigandPNGBDBM50001765(Halcion | CHEMBL646 | 8-chloro-6-(2-chlorophenyl)-...)
Affinity DataKi:  44.2nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent

TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50001765(Halcion | CHEMBL646 | 8-chloro-6-(2-chlorophenyl)-...)
Affinity DataKi:  44.2nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2024
Entry Details
Go to US Patent

LigandPNGBDBM50001765(Halcion | CHEMBL646 | 8-chloro-6-(2-chlorophenyl)-...)
Affinity DataKi:  46.2nMAssay Description:The affinity of compounds at GABAA γ1 subunit-containing receptors was measured by competition for [3H]RO7239181 (67.3 Ci/mmol: Roche) binding t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent

LigandPNGBDBM50001765(Halcion | CHEMBL646 | 8-chloro-6-(2-chlorophenyl)-...)
Affinity DataKi:  46.2nMAssay Description:Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]RO7239181 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2024
Entry Details
Go to US Patent

TargetPlatelet-activating factor receptor(Human)
Rhone-Poulenc Sante

Curated by PDSP Ki Database
LigandPNGBDBM50001765(Halcion | CHEMBL646 | 8-chloro-6-(2-chlorophenyl)-...)
Affinity DataKi:  699nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2011
Entry Details
PubMed
TargetPlatelet-activating factor receptor(Human)
Rhone-Poulenc Sante

Curated by PDSP Ki Database
LigandPNGBDBM50001765(Halcion | CHEMBL646 | 8-chloro-6-(2-chlorophenyl)-...)
Affinity DataKi:  2.49E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2011
Entry Details
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Human)
University of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50001765(Halcion | CHEMBL646 | 8-chloro-6-(2-chlorophenyl)-...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-6-beta-3-gamma-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2012
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-6(Human)
Merck Sharp & Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50001765(Halcion | CHEMBL646 | 8-chloro-6-(2-chlorophenyl)-...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2012
Entry Details
PubMed