BDBM688418 4-chloro-N1-(2-hydroxy-1,1- dimethyl-ethyl)-N3-[3-methyl-5-(2- phenylethynyl)-2-pyridyl]benzene- 1,3-dicarboxamide::US20240190824, Compound 17

SMILES Cc1cc(cnc1NC(=O)c1cc(ccc1Cl)C(=O)NC(C)(C)CO)C#Cc1ccccc1

InChI Key InChIKey=KGZQCAMAOVAVGI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 688418   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM688418(US20240190824, Compound 17 | 4-chloro-N1-(2-hydrox...)
Affinity DataIC50: 180nMAssay Description:TBDCHO-K1 cells stably expressing human TREK-1 or HEK293 cells stably expressing human TREK-2 are plated in 384-well plates, cultured overnight, load...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM688418(US20240190824, Compound 17 | 4-chloro-N1-(2-hydrox...)
Affinity DataIC50: 51nMAssay Description:TBDCHO-K1 cells stably expressing human TREK-1 or HEK293 cells stably expressing human TREK-2 are plated on glass coverslips, and voltage clamped in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent