BDBM688411 N-[4-chloro-3-[[3-flluoro-5-(2- phenylethynyl)-2- pyridyl]carbamooyl]phenyl]-1,4- dioxane-2-carboxamide::US20240190824, Compound 10

SMILES Fc1cc(cnc1NC(=O)c1cc(NC(=O)C2COCCO2)ccc1Cl)C#Cc1ccccc1

InChI Key InChIKey=OBUPVADXPPYDOE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 688411   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM688411(US20240190824, Compound 10 | N-[4-chloro-3-[[3-fll...)
Affinity DataIC50: 200nMAssay Description:TBDCHO-K1 cells stably expressing human TREK-1 or HEK293 cells stably expressing human TREK-2 are plated in 384-well plates, cultured overnight, load...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM688411(US20240190824, Compound 10 | N-[4-chloro-3-[[3-fll...)
Affinity DataIC50: 25nMAssay Description:TBDCHO-K1 cells stably expressing human TREK-1 or HEK293 cells stably expressing human TREK-2 are plated on glass coverslips, and voltage clamped in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2024
Entry Details
Go to US Patent