BDBM677015 US11993596, Compound WX026::US20240294526, Compound WX026

SMILES CCOc1cc2CCn3c(c\c(=N/c4c(C)cc(C)cc4C)n(CCNC(=O)c4[nH]nnc4OC)c3=O)-c2cc1OC

InChI Key InChIKey=PCJSRTIXCOOFGR-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 677015   

TargetCytochrome P450 1A2(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM677015(US11993596, Compound WX026 | US20240294526, Compou...)
Affinity DataIC50: 5.00E+4nMAssay Description:A total of 5 specific probe substrates of 5 isoenzymes of CYP, namely phenacetin (CYP1A2), diclofenac (CYP2C9), (S)-mephenytoin (CYP2C19), dextrometh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
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TargetCytochrome P450 2C9(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM677015(US11993596, Compound WX026 | US20240294526, Compou...)
Affinity DataIC50: 2.00E+4nMAssay Description:A total of 5 specific probe substrates of 5 isoenzymes of CYP, namely phenacetin (CYP1A2), diclofenac (CYP2C9), (S)-mephenytoin (CYP2C19), dextrometh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
Go to US Patent

TargetCytochrome P450 2C19(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM677015(US11993596, Compound WX026 | US20240294526, Compou...)
Affinity DataIC50: 5.00E+4nMAssay Description:A total of 5 specific probe substrates of 5 isoenzymes of CYP, namely phenacetin (CYP1A2), diclofenac (CYP2C9), (S)-mephenytoin (CYP2C19), dextrometh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
Go to US Patent

TargetCytochrome P450 2D6(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM677015(US11993596, Compound WX026 | US20240294526, Compou...)
Affinity DataIC50: 5.00E+4nMAssay Description:A total of 5 specific probe substrates of 5 isoenzymes of CYP, namely phenacetin (CYP1A2), diclofenac (CYP2C9), (S)-mephenytoin (CYP2C19), dextrometh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
Go to US Patent

TargetCytochrome P450 3A4(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM677015(US11993596, Compound WX026 | US20240294526, Compou...)
Affinity DataIC50: 1.60E+4nMAssay Description:A total of 5 specific probe substrates of 5 isoenzymes of CYP, namely phenacetin (CYP1A2), diclofenac (CYP2C9), (S)-mephenytoin (CYP2C19), dextrometh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
Go to US Patent

TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM677015(US11993596, Compound WX026 | US20240294526, Compou...)
Affinity DataIC50: 0.0100nMAssay Description:Procedure:1. The recombinant human PDE4B enzyme and enzyme substrate (1 uM cAMP) were each dissolved in newly prepared experimental buffer solution;2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
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TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM677015(US11993596, Compound WX026 | US20240294526, Compou...)
Affinity DataIC50: 2.5nMAssay Description:Procedure:1. The recombinant human PDE4B enzyme and enzyme substrate (1 uM cAMP) were each dissolved in newly prepared experimental buffer solution;2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2024
Entry Details
Go to US Patent

TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM677015(US11993596, Compound WX026 | US20240294526, Compou...)
Affinity DataIC50: 0.0100nMAssay Description:Experimental objective: to determine the AMP/GMP expression based on fluorescence polarization, i.e., to trace binding of AMP/GMP to antibody so as t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2024
Entry Details
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TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM677015(US11993596, Compound WX026 | US20240294526, Compou...)
Affinity DataIC50: 2.5nMAssay Description:Experimental objective: to determine the AMP/GMP expression based on fluorescence polarization, i.e., to trace binding of AMP/GMP to antibody so as t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2024
Entry Details
Go to US Patent