BDBM664388 N-(5-(2- (cyclobutylamino)acetamido)- 2-methylpyridin-3-yl)-2-(5,6- dihydro-4H-pyrrolo[1,2- b]pyrazol-3-yl)pyrazolo[5,1- b]thiazole-7-carboxamide::US20240109917, Example 471

SMILES Cc1ncc(NC(=O)CNC2CCC2)cc1NC(=O)c1cnn2cc(sc12)-c1cnn2CCCc12

InChI Key InChIKey=UEWCYTKIZNGSEP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 664388   

TargetPlatelet-derived growth factor receptor beta(Human)
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM664388(N-(5-(2- (cyclobutylamino)acetamido)- 2-methylpyri...)
Affinity DataIC50: 0.100nMAssay Description:Stock Solutions:Assay buffer stock solution, contains 50 mM Hepes, 10 mM MgCl2, 1 mM EGTA, and 0.01% Brij-35, 0.01% ovalbumin, 2 mM DTT at pH 7.5, in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
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TargetPlatelet-derived growth factor receptor beta(Human)
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM664388(N-(5-(2- (cyclobutylamino)acetamido)- 2-methylpyri...)
Affinity DataIC50: 1nMAssay Description:Stock Solutions:Assay buffer stock contains 50 mM HEPES pH7.5, 10 mM MgCl2, 0.01% Brij-35, 1 mM EGTA.Tb-labeled inactive PDGFRβ. 3.6 μM in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM664388(N-(5-(2- (cyclobutylamino)acetamido)- 2-methylpyri...)
Affinity DataIC50: 7.50E+3nMAssay Description:Assay Procedure:Step 1. Dispensing inhibitors/controls: Using Echo, dispense 10 nL/well compound serial dilutions in DMSO to columns 1-22 (in 384-wel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
Go to US Patent