BDBM664148 2-(2-Methoxypyridin-3-yl)-N- (2-methyl-5-((2-(pyrrolidin-1- yl)ethyl)carbamoyl)pyridin-3- yl)pyrazolo[5,1-b]thiazole-7- carboxamide::US20240109917, Example 229

SMILES COc1ncccc1-c1cn2ncc(C(=O)Nc3cc(cnc3C)C(=O)NCCN3CCCC3)c2s1

InChI Key InChIKey=WYIXTTAGWRKOJO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 664148   

TargetPlatelet-derived growth factor receptor beta(Human)
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM664148(2-(2-Methoxypyridin-3-yl)-N- (2-methyl-5-((2-(pyrr...)
Affinity DataIC50: 0.200nMAssay Description:Stock Solutions:Assay buffer stock solution, contains 50 mM Hepes, 10 mM MgCl2, 1 mM EGTA, and 0.01% Brij-35, 0.01% ovalbumin, 2 mM DTT at pH 7.5, in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
Go to US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM664148(2-(2-Methoxypyridin-3-yl)-N- (2-methyl-5-((2-(pyrr...)
Affinity DataIC50: 1.60nMAssay Description:Stock Solutions:Assay buffer stock contains 50 mM HEPES pH7.5, 10 mM MgCl2, 0.01% Brij-35, 1 mM EGTA.Tb-labeled inactive PDGFRβ. 3.6 μM in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Actelion Pharmaceuticals

US Patent
LigandPNGBDBM664148(2-(2-Methoxypyridin-3-yl)-N- (2-methyl-5-((2-(pyrr...)
Affinity DataIC50: 833nMAssay Description:Assay Procedure:Step 1. Dispensing inhibitors/controls: Using Echo, dispense 10 nL/well compound serial dilutions in DMSO to columns 1-22 (in 384-wel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
Go to US Patent