BDBM576085 Compound 38 (4-(1-(2,6-dichlorobenzyl)-2-methyl-1H-pyrrolo[3,2-b]pyridin-6-yl)-6-methyl-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one)::US11466034, Example 38

SMILES Cc1cc2ncc(cc2n1Cc1c(Cl)cccc1Cl)-c1cn(C)c(=O)c2n(ccc12)S(=O)(=O)c1ccc(C)cc1

InChI Key InChIKey=WNRCBHDCHDGVMQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 576085   

TargetBromodomain-containing protein 4 [44-167](Human)
Betta Pharmaceuticals

US Patent
LigandPNGBDBM576085(Compound 38 (4-(1-(2,6-dichlorobenzyl)-2-methyl-1H...)
Affinity DataIC50: 7.30nMAssay Description:The assays of BRD4 (D1) and BRD4 (D2) were conducted in a 384-well polystyrene plate. The test compounds were first serially diluted in DMSO and the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [349-460](Human)
Betta Pharmaceuticals

US Patent
LigandPNGBDBM576085(Compound 38 (4-(1-(2,6-dichlorobenzyl)-2-methyl-1H...)
Affinity DataIC50: 2.20nMAssay Description:The assays of BRD4 (D1) and BRD4 (D2) were conducted in a 384-well polystyrene plate. The test compounds were first serially diluted in DMSO and the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
Go to US Patent