BDBM576064 6-methyl-4-(2-methyl-1-(4- (trifluoromethyl)benzyl)-1H- imidazo[4,5-b]pyrazin-6-yl)-1H- pyrrolo[2,3-c]pyridin-7(6H)- one::US11466034, Example 19

SMILES Cc1nc2ncc(nc2n1Cc1ccc(cc1)C(F)(F)F)-c1cn(C)c(=O)c2[nH]ccc12

InChI Key InChIKey=SONHSXTYAWZZFU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 576064   

TargetBromodomain-containing protein 4 [44-167](Human)
Betta Pharmaceuticals

US Patent
LigandPNGBDBM576064(6-methyl-4-(2-methyl-1-(4- (trifluoromethyl)benzyl...)
Affinity DataIC50: 9.10nMAssay Description:The assays of BRD4 (D1) and BRD4 (D2) were conducted in a 384-well polystyrene plate. The test compounds were first serially diluted in DMSO and the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [349-460](Human)
Betta Pharmaceuticals

US Patent
LigandPNGBDBM576064(6-methyl-4-(2-methyl-1-(4- (trifluoromethyl)benzyl...)
Affinity DataIC50: 1.60nMAssay Description:The assays of BRD4 (D1) and BRD4 (D2) were conducted in a 384-well polystyrene plate. The test compounds were first serially diluted in DMSO and the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
Go to US Patent