BDBM50512464 CHEMBL4555442

SMILES Cn1cc(cn1)-c1n[nH]c2ccc(NCc3cc(F)ccc3S(C)(=O)=O)cc12

InChI Key InChIKey=VXKMMMZVPVHQBU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50512464   

TargetHigh affinity nerve growth factor receptor(Human)
Asahi Kasei Pharma

Curated by ChEMBL
LigandPNGBDBM50512464(CHEMBL4555442)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human GST-tagged TRKA (436 to 790) expressed in baculovirus expression system using TK-biotin peptide as substrate incubated for 45 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Asahi Kasei Pharma

Curated by ChEMBL
LigandPNGBDBM50512464(CHEMBL4555442)
Affinity DataIC50: 1.70nMAssay Description:Antagonist activity at prolink-tagged full length human TrkA expressed in U2OS cells assessed as inhibition of NGF-induced receptor phosphorylation b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Asahi Kasei Pharma

Curated by ChEMBL
LigandPNGBDBM50512464(CHEMBL4555442)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human GST-tagged TRKB (456 to 822) expressed in baculovirus expression system using TK-biotin peptide as substrate incubated for 45 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed