BDBM50506263 CHEMBL4465054::US11401295, Compound 2',3'-cGAMP
SMILES [H][C@]12COP(O)(=O)O[C@@]3([H])[C@@H](O)[C@@H](O[C@]3([H])COP(O)(=O)O[C@@]([H])([C@@H](O1)n1cnc3c1nc(N)[nH]c3=O)[C@@H]2O)n1cnc2c(N)ncnc12
InChI Key InChIKey=XRILCFTWUCUKJR-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 36 hits for monomerid = 50506263
Affinity DataEC50: 4.38E+4nMAssay Description:Activation of STING signalling pathway in human THP1-Dual cells assessed as increase in NF-kappaB-SEAP activation incubated for 24 hrs by QUANTI-Blue...More data for this Ligand-Target Pair
Affinity DataEC50: 2.84E+4nMAssay Description:Agonist activity at human wild type full length STING expressed in 293T cells incubated for 7 hrs by luciferase/cell based assayMore data for this Ligand-Target Pair
Affinity DataEC50: 3.01E+4nMAssay Description:Agonist activity at STING in human wild-type THP1-Dual cells co-expressing ISRE reporter assessed as IRF-mediated immune response incubated for 24 hr...More data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Displacement of radiolabeled [3H]-2',3'-cGAMP from wild type human STING incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKd: 6.20nMAssay Description:Binding affinity to wild type human STING assessed as dissociation constant by Surface plasmon resonance assayMore data for this Ligand-Target Pair
Affinity DataKd: <0.0100nMAssay Description:Binding affinity to wild type mouse STING assessed as dissociation constant by Surface plasmon resonance assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.14E+4nMAssay Description:Agonist activity at STING in human THP1-Dual cells incubated for 20 hrs by Quanti-luc reagent based assayMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at STING in human STHP1-Dual KO-STING cells incubated for 20 hrs by Quanti-luc reagent based assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.38E+4nMAssay Description:Agonist activity at STING in mouse RAW-Lucia ISG cells by luciferase gene reporter assayMore data for this Ligand-Target Pair
Affinity DataEC50: 20nMAssay Description:Agonist activity at human wild type STING expressed in 293T cells by digitonin cell based assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.90E+4nMAssay Description:Activation of STING signalling pathway in human THP1-Dual cells assessed as increase in IRF-luciferase activation incubated for 24 hrs by QUANTI-luc ...More data for this Ligand-Target Pair
Affinity DataEC50: 1.40E+4nMAssay Description:Activation of STING signalling pathway in human PBMC cells assessed as increase in IFN-beta level incubated for 4 hrs by ELISA methodMore data for this Ligand-Target Pair
Affinity DataEC50: 1.28E+4nMAssay Description:Activation of STING signalling pathway in human PBMC cells assessed as increase in CXCL10 level incubated for 4 hrs by ELISA methodMore data for this Ligand-Target Pair
Affinity DataEC50: 2.50E+4nMAssay Description:Activation of STING signalling pathway in human PBMC cells assessed as increase in IL-6 level incubated for 4 hrs by ELISA methodMore data for this Ligand-Target Pair
Affinity DataEC50: 4.86E+4nMAssay Description:Agonist activity at STING in human THP-1 reporter cells incubated for 24 hrs by QUANTI-Luc assayMore data for this Ligand-Target Pair
Affinity DataEC50: 131nMAssay Description:Agonist activity at STING in human THP-1 reporter cells incubated for 4 hrs in presence of lipofectamine 2000 by QUANTI-Luc assayMore data for this Ligand-Target Pair
Affinity DataEC50: 28nMAssay Description:Agonist activity at STING in PMA-treated human THP-1 reporter cells incubated for 30 mins in presence of digitonin by QUANTI-Luc assayMore data for this Ligand-Target Pair
Affinity DataKd: 3.80nMAssay Description:Binding affinity to wild-type STING (unknown origin) assessed as dissociation constant by ITC analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 1.88E+4nMAssay Description:Activation of STING in mouse RAW-Lucia ISG cells assessed as induction of type I IFNs stimulation by measuring induction of IRF pathway incubated for...More data for this Ligand-Target Pair
Affinity DataEC50: 40nMAssay Description:Activation of recombinant human STING haplotype G230A/R293Q mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by brigh...More data for this Ligand-Target Pair
Affinity DataEC50: 1.37E+4nMAssay Description:Activation of recombinant human wild-type STING expressed in 293T cells incubated for 7 hrs in absence of digitonin A by bright Glo-luciferase report...More data for this Ligand-Target Pair
Affinity DataEC50: 20nMAssay Description:Activation of recombinant human STING haplotype R71H/G230A/R293Q mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by ...More data for this Ligand-Target Pair
Affinity DataEC50: 50nMAssay Description:Activation of recombinant human STING haplotype R293Q mutant expressed in 293T cells measured after 30 mins in presence of digitonin A by bright Glo-...More data for this Ligand-Target Pair
Affinity DataKd: 3.79nMAssay Description:Binding affinity to wild type human STING (139 to 379 residues) by ITC assayMore data for this Ligand-Target Pair
Affinity DataEC50: 3.86E+4nMAssay Description:Agonist activity at STING in human THP1 cells assessed as stimulation of IRF3 pathway measured after 20 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.5nMAssay Description:Inhibition of anti 6His antibody-labeled terbium cryptate binding to human wild-type full-length 6His-tagged d2-labeled STING measured after 4 hrs by...More data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+5nMAssay Description:Induction of IRF3 pathway in STING knockout human THP1 cells measured after 20 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 20nMAssay Description:Activation of recombinant human wild-type STING expressed in 293T cells measured after 30 mins in presence of digitonin A by bright Glo-luciferase re...More data for this Ligand-Target Pair
Affinity DataEC50: 7.20E+3nMAssay Description:Activation of STING in human THP-1-Dual cells assessed as induction of type I IFNs by measuring stimulation of IRF pathway incubated for 48 hrs by lu...More data for this Ligand-Target Pair
Affinity DataEC50: 3.91E+4nMAssay Description:Activation of STING in human THP-1-Dual cells assessed as induction of type I IFNs by measuring stimulation of NF-kappaB pathway incubated for 48 hrs...More data for this Ligand-Target Pair
Affinity DataEC50: 1.96E+4nMAssay Description:Activation of STING in human blood assessed as induction of type I IFNs incubated for 18 to 20 hrs by QUANTI-Blue assayMore data for this Ligand-Target Pair
TargetStimulator of interferon genes protein [140-379](Mountain lion)
Shanghai Jemincare Pharmaceuticals
US Patent
Shanghai Jemincare Pharmaceuticals
US Patent
Affinity DataIC50: 6.66E+3nMAssay Description:Fluorescence polarization assay (FP assay) was used to detect the affinity of compounds for human STING proteins. There were a certain amount of fluo...More data for this Ligand-Target Pair
Affinity DataEC50: 5.80nMAssay Description:Binding affinity to 6His-tagged human STING measured after 3 hrs by HTRF assayMore data for this Ligand-Target Pair
Affinity DataEC50: 50nMAssay Description:Binding affinity to human STING incubated for 60 mins measured by competitive TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKd: 3.79E+3nMAssay Description:Agonist activity at wild type human STING C-terminal domain (139 to 379 residues) assessed as dissociation constant by isothermal titration calorimet...More data for this Ligand-Target Pair
Affinity DataEC50: 1.96E+4nMAssay Description:Agonist activity at STING (unknown origin)More data for this Ligand-Target Pair