BDBM50460742 CHEMBL4228634

SMILES COc1ccccc1-c1nnc2sc(\C=C\c3ccco3)nn12

InChI Key InChIKey=SDVMNLXLFVWQDH-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50460742   

TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Human)
University of Science and Technology of China

Curated by ChEMBL
LigandPNGBDBM50460742(CHEMBL4228634)
Affinity DataIC50: 9.70E+3nMAssay Description:Inhibition of recombinant human His6-SUMO tagged DOT1L (1 to 416 residues) expressed in Escherichia coli BL21(DE3) using oligonucleosome as substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase, H3 lysine-79 specific(Human)
University of Science and Technology of China

Curated by ChEMBL
LigandPNGBDBM50460742(CHEMBL4228634)
Affinity DataKd:  7.08E+3nMAssay Description:Binding affinity to recombinant human His6-SUMO tagged DOT1L (1 to 416 residues) expressed in Escherichia coli BL21(DE3) by surface plasmon resonance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed