BDBM50293756 2-(4-(methylthio)phenylamino)-1-(2-(trifluoromethyl)benzyl)-1H-benzo[d]imidazole-5-carboxamide::CHEMBL561696::KSP Inhibitor, 4a

SMILES CSc1ccc(Nc2nc3cc(ccc3n2Cc2ccccc2C(F)(F)F)C(N)=O)cc1

InChI Key InChIKey=LDIUIXFIAWISPB-UHFFFAOYSA-N

Data  8 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50293756   

TargetKinesin-like protein KIF11(Human)
Merck Research Laboratories

LigandPNGBDBM50293756(KSP Inhibitor, 4a | CHEMBL561696 | 2-(4-(methylthi...)
Affinity DataKd:  2.00E+3nMAssay Description:Binding assay using temperature-dependent circular dichroism (TdCD). In TdCD, the loss of protein secondary structure was monitored as a function of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2013
Entry Details Article
PubMed
TargetKinesin-like protein KIF11(Human)
Merck Research Laboratories

LigandPNGBDBM50293756(KSP Inhibitor, 4a | CHEMBL561696 | 2-(4-(methylthi...)
Affinity DataIC50: 520nMAssay Description:Inhibition of human kinesin spindle protein by endpoint assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetKinesin-like protein KIF3B(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50293756(KSP Inhibitor, 4a | CHEMBL561696 | 2-(4-(methylthi...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Kif3BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetKinesin heavy chain isoform 5A(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50293756(KSP Inhibitor, 4a | CHEMBL561696 | 2-(4-(methylthi...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of nKHCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50293756(KSP Inhibitor, 4a | CHEMBL561696 | 2-(4-(methylthi...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4 coincubated with compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50293756(KSP Inhibitor, 4a | CHEMBL561696 | 2-(4-(methylthi...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6 coincubated with compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50293756(KSP Inhibitor, 4a | CHEMBL561696 | 2-(4-(methylthi...)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of CYP2C9 coincubated with compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50293756(KSP Inhibitor, 4a | CHEMBL561696 | 2-(4-(methylthi...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of CYP2D6 preincubated with compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50293756(KSP Inhibitor, 4a | CHEMBL561696 | 2-(4-(methylthi...)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of CYP2C9 preincubated with compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed