BDBM50293744 2-(4-sulfamoylphenylamino)-1-(2-(trifluoromethyl)benzyl)-1H-benzo[d]imidazole-5-carboxamide::CHEMBL563643::KSP Inhibitor, 4e

SMILES NC(=O)c1ccc2n(Cc3ccccc3C(F)(F)F)c(Nc3ccc(cc3)S(N)(=O)=O)nc2c1

InChI Key InChIKey=DVSBIKLKENVWGG-UHFFFAOYSA-N

Data  3 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50293744   

TargetKinesin-like protein KIF11(Human)
Merck Research Laboratories

LigandPNGBDBM50293744(KSP Inhibitor, 4e | CHEMBL563643 | 2-(4-sulfamoylp...)
Affinity DataKd:  600nMAssay Description:Binding assay using temperature-dependent circular dichroism (TdCD). In TdCD, the loss of protein secondary structure was monitored as a function of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2013
Entry Details Article
PubMed
TargetKinesin-like protein KIF11(Human)
Merck Research Laboratories

LigandPNGBDBM50293744(KSP Inhibitor, 4e | CHEMBL563643 | 2-(4-sulfamoylp...)
Affinity DataIC50: 7.40E+3nMAssay Description:Inhibition of human kinesin spindle protein by endpoint assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetKinesin-like protein KIF3B(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50293744(KSP Inhibitor, 4e | CHEMBL563643 | 2-(4-sulfamoylp...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Kif3BMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetKinesin heavy chain isoform 5A(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50293744(KSP Inhibitor, 4e | CHEMBL563643 | 2-(4-sulfamoylp...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of nKHCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed