BDBM50282232 CHEMBL4165132

SMILES Cn1nccc1NS(=O)(=O)c1ccc(Cl)cc1

InChI Key InChIKey=JUGZPBNQEQTHMX-UHFFFAOYSA-N

Data  2 KI  4 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50282232   

TargetOxytocin receptor(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50282232(CHEMBL4165132)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human OTR expressed in HEK293 cell membranes assessed as inhibition of OT-induced IP1 accumulation measured after 1 hr by fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2020
Entry Details Article
PubMed
TargetVasopressin V1a receptor(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50282232(CHEMBL4165132)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human vasopressin 1a receptor expressed in HEK293 cell membranes assessed as inhibition of AVP-induced IP1 accumulation measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2020
Entry Details Article
PubMed
TargetOxytocin receptor(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50282232(CHEMBL4165132)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human OTR expressed in CHO cell membranes assessed as inhibition of OT-induced IP1 accumulation measured after 1 hr by fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2020
Entry Details Article
PubMed
TargetVasopressin V1a receptor(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50282232(CHEMBL4165132)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human vasopressin 1a receptor expressed in CHO cell membranes assessed as inhibition of AVP-induced IP1 accumulation by measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2020
Entry Details Article
PubMed
TargetOxytocin receptor(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50282232(CHEMBL4165132)
Affinity DataEC50:  0.0794nMAssay Description:Antagonist activity at human OTR expressed in HEK293 cell membranes assessed as inhibition of OT-induced increase in Ca2+ flux preincubated for 5 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2020
Entry Details Article
PubMed
TargetVasopressin V1a receptor(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50282232(CHEMBL4165132)
Affinity DataEC50:  0.126nMAssay Description:Antagonist activity at human vasopressin 1a receptor expressed in HEK293 cell membranes assessed as inhibition of AVP-induced increase in Ca2+ flux p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2020
Entry Details Article
PubMed
TargetOxytocin receptor(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50282232(CHEMBL4165132)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-oxytocin from human OTR expressed in HEK293 cell membranes after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2020
Entry Details Article
PubMed
TargetVasopressin V1a receptor(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50282232(CHEMBL4165132)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-vasopressin from human vasopressin 1a receptor expressed in HEK293 cell membranes after 90 mins by microbeta scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2020
Entry Details Article
PubMed