BDBM48320 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy-benzamide;hydrochloride::4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide;hydrochloride::4-azanyl-5-chloranyl-N-[2-(diethylamino)ethyl]-2-methoxy-benzamide;hydrochloride::METOCLOPRAMIDE::METOCLOPRAMIDE HYDROCHLORIDE::MLS000069667::Metochloropramide::SMR000058471::US11147820, Compound Metoclopramide::US11717500, Compound Metoclopramide::US9132134, Metoclopramide::cid_23659
SMILES CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC
InChI Key InChIKey=TTWJBBZEZQICBI-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 93 hits for monomerid = 48320
Affinity DataIC50: 480nMAssay Description:Binding affinity against dopamine D2 receptor in rat brain synaptic membrane using [3H]-spiperone as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 880nMAssay Description:Inhibition of [3H]GR-65630 binding to rat cortical membrane 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 228nMAssay Description:Concentration required to inhibit the binding of radioligand [3H]GR-65630 to serotonin 5-hydroxytryptamine-3 receptor (5-HT 3 receptor)in rat brain c...More data for this Ligand-Target Pair
Affinity DataIC50: 912nMAssay Description:Concentration of compound required to inhibit the binding of radioligand [3H]GR-113808 to serotonin 5-hydroxytryptamine 4 receptor in guinea-pig stri...More data for this Ligand-Target Pair
Affinity DataIC50: 61.3nMAssay Description:Concentration of compound required to inhibit the binding of radioligand [3H](R)-7-OH-DPAT to Dopamine receptor D3 in rat striatumMore data for this Ligand-Target Pair
Affinity DataIC50: 444nMAssay Description:Concentration of compound required to inhibit the binding of radioligand [3H]spiperone to Dopamine receptor D2 in rat brain synaptic membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 565nMAssay Description:In vitro antagonistic activity against Dopamine receptor D2 was evaluated for the inhibition of [3H]spiperone bindingMore data for this Ligand-Target Pair
Affinity DataIC50: 630nMAssay Description:Inhibitory activity against dopamine receptor D2 by 3H ligand binding experiments.More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of guinea pig acetylcholinesteraseMore data for this Ligand-Target Pair
Affinity DataIC50: 880nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 receptor in rat cortical membrane using [3H]GR-65630 as radioligandMore data for this Ligand-Target Pair
Affinity DataKd: 1.37E+6nMAssay Description:Binding affinity to Wistar rat serum albuminMore data for this Ligand-Target Pair
Affinity DataIC50: 820nMAssay Description:Inhibitory concentration required for displacing radioligand [3H]SPI from DA D-2 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 5.70nMAssay Description:5-hydroxytryptamine 4 receptor agonist activity, concentration which gave 50% increase in the response to electrically-stimulated myenteric plexus an...More data for this Ligand-Target Pair
Affinity DataIC50: 3.28E+4nMAssay Description:Inhibitory activity against Alpha-1 adrenergic receptor by 3H ligand binding experiments.More data for this Ligand-Target Pair
Affinity DataIC50: 7.80E+3nMAssay Description:Inhibitory activity against 5-hydroxytryptamine 1 receptor by 3H ligand binding experiments.More data for this Ligand-Target Pair
Affinity DataIC50: 1.32E+4nMAssay Description:Inhibitory activity against 5-hydroxytryptamine 2 receptor by 3H ligand binding experiments.More data for this Ligand-Target Pair
TargetAlpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor(Rat)
Dainippon Pharmaceutical
Curated by ChEMBL
Dainippon Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 7.70E+3nMAssay Description:Inhibitory activity against alpha-2 adrenergic receptor by 3H ligand binding experiments.More data for this Ligand-Target Pair
Affinity DataIC50: 480nMAssay Description:Inhibition of [3H]- spiperone binding to rat brain Dopamine receptor D2More data for this Ligand-Target Pair
Affinity DataIC50: 9.48E+4nMAssay Description:Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopyMore data for this Ligand-Target Pair
Affinity DataEC50: 794nMAssay Description:Agonist activity against 5-HT4 receptor in rat esophageal muscularis mucosaeMore data for this Ligand-Target Pair
Affinity DataEC50: 794nMAssay Description:Tested for its agonist potency against the 5-hydroxytryptamine 4 receptor located in the rat esophageal tunica muscularis mucosaeMore data for this Ligand-Target Pair
Affinity DataKd: 224nMAssay Description:Binding affinity towards 5-hydroxytryptamine 3 receptor was determined by using [3H]-ICS 205-930 as radioligand in mouse N1E 115 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 1.92E+3nMAssay Description:In vitro relaxation of carbachol pre-contracted rat oesophageal TMM.More data for this Ligand-Target Pair
Affinity DataIC50: 1.35E+5nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of recombinant MPO (unknown origin) assessed as reduction in LDL oxidation in presence of H2O2 and HCl after 5 mins by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of bovine milk LPO assessed as reduction in NaOSCN production in presence of H2O2/NaSCN after 5 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 350nMAssay Description:Inhibition of recombinant MPO (unknown origin) assessed as reduction in taurine chloramine production preincubated with enzyme and taurine followed b...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
Affinity DataIC50: 280nMAssay Description:The functional antagonist assay was performed as described in Payne, S. L et al. (2002) J. Neurochem., 82: 1106-1117, hereby incorporated by referenc...More data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:It is well-known that drug compounds that have an affinity for the striatal dopamine D2 may give rise to adverse side effects, such as short-term ext...More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: John A. Katzenellenbogen, ...More data for this Ligand-Target Pair
Affinity DataKi: 16nMAssay Description:The pharmacological profile of metopimazine, metopimazine acid (MPZA), domperidone, and metoclopramide were assessed by radioligand binding and by a ...More data for this Ligand-Target Pair
Affinity DataKi: 27nMAssay Description:Displacement of [125I]iodosulpiride from human Dopamine receptor D3 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 64nMAssay Description:The pharmacological profile of metopimazine, metopimazine acid (MPZA), domperidone, and metoclopramide were assessed by radioligand binding and by a ...More data for this Ligand-Target Pair
Affinity DataKi: 80nMAssay Description:Compound was evaluated for the binding affinity at Dopamine receptor D2More data for this Ligand-Target Pair
Affinity DataKi: 104nMAssay Description:Compound was evaluated for binding affinity towards DA D-2 receptor using radioligand [3H]SPIMore data for this Ligand-Target Pair
Affinity DataKi: 104nMAssay Description:Compound was evaluated for binding affinity towards DA D-2 receptor using radioligand [3H]SPIMore data for this Ligand-Target Pair
Affinity DataKi: 113nMAssay Description:Binding affinity to dopamine receptor D2More data for this Ligand-Target Pair
Affinity DataKi: 158nMAssay Description:Tested for its binding affinity by measuring its ability to displace [3H]granisetron from 5-hydroxytryptamine 3 receptor in rat cortexMore data for this Ligand-Target Pair
Affinity DataKi: 200nMAssay Description:Binding affinity to 5-hydroxytryptamine 3 receptor using [3H]GR-65630 as radioligand in rat cortexMore data for this Ligand-Target Pair
Affinity DataKi: 210nMAssay Description:Inhibition of [3H]GR-65630 binding to rat cortical membrane serotonin 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair