BDBM31483 substituted biphenyl derivative, 36w

SMILES CC(C)CNC(=O)c1ccc(c(c1)C(O)=O)-c1ccc(Cc2ccccc2)cc1C(=O)Nc1ccc(cc1)C(N)=N

InChI Key InChIKey=GEJPIBYDWDPPLK-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 31483   

TargetCoagulation factor VII(Human)
Biocryst Pharmaceuticals

LigandPNGBDBM31483(substituted biphenyl derivative, 36w)
Affinity DataIC50: 21nMpH: 7.2 T: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2009
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Biocryst Pharmaceuticals

LigandPNGBDBM31483(substituted biphenyl derivative, 36w)
Affinity DataIC50: 570nMT: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2009
Entry Details Article
PubMed
TargetPlasminogen(Human)
Biocryst Pharmaceuticals

LigandPNGBDBM31483(substituted biphenyl derivative, 36w)
Affinity DataIC50: 656nMT: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Biocryst Pharmaceuticals

LigandPNGBDBM31483(substituted biphenyl derivative, 36w)
Affinity DataIC50: 8.51E+3nMT: 2°CAssay Description:Thrombin assay reactions were performed in a reaction mixture containing thrombin, and test compounds were added at varied concentrations. The reacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Biocryst Pharmaceuticals

LigandPNGBDBM31483(substituted biphenyl derivative, 36w)
Affinity DataIC50: 1.75E+3nMT: 2°CAssay Description:Thrombin assay reactions were performed in a reaction mixture containing thrombin, and test compounds were added at varied concentrations. The reacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2009
Entry Details Article
PubMed