BDBM31463 substituted biphenyl derivative, 36c

SMILES CCc1ccc(c(c1)C(=O)Nc1ccc(cc1)C(N)=N)-c1ccc(cc1C(O)=O)C(=O)NCC(C)C

InChI Key InChIKey=OLFYUUPVCGARIA-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 31463   

TargetCoagulation factor VII(Human)
Biocryst Pharmaceuticals

LigandPNGBDBM31463(substituted biphenyl derivative, 36c)
Affinity DataIC50: 97nMpH: 7.2 T: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2009
Entry Details Article
PubMed
TargetSerine protease 1(Bovine)
Biocryst Pharmaceuticals

LigandPNGBDBM31463(substituted biphenyl derivative, 36c)
Affinity DataIC50: 5.99E+3nMT: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Biocryst Pharmaceuticals

LigandPNGBDBM31463(substituted biphenyl derivative, 36c)
Affinity DataIC50: 1.23E+4nMT: 2°CAssay Description:Thrombin assay reactions were performed in a reaction mixture containing thrombin, and test compounds were added at varied concentrations. The reacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2009
Entry Details Article
PubMed
TargetPlasminogen(Human)
Biocryst Pharmaceuticals

LigandPNGBDBM31463(substituted biphenyl derivative, 36c)
Affinity DataIC50: 5.00E+3nMT: 2°CAssay Description:TF-FVIIa assay reactions were performed in a mixture containing FVIIa , lapidated tissue factor, in an assay buffer in the presence of test compounds...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2009
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Biocryst Pharmaceuticals

LigandPNGBDBM31463(substituted biphenyl derivative, 36c)
Affinity DataIC50: 5.00E+4nMT: 2°CAssay Description:Thrombin assay reactions were performed in a reaction mixture containing thrombin, and test compounds were added at varied concentrations. The reacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2009
Entry Details Article
PubMed