BDBM186573 US10787472, Compound 9::US20230303497, Example VX-150::US9163042, 9
SMILES Cc1cc(F)ccc1Oc1cc(ccc1C(=O)Nc1ccn(COP(O)(O)=O)c(=O)c1)C(F)(F)F
InChI Key InChIKey=SQDQNNKQTHOQHO-UHFFFAOYSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 186573
Affinity DataIC50: 330nMAssay Description:Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...More data for this Ligand-Target Pair
Affinity DataIC50: 330nMAssay Description:Patch clamp electrophysiology was used to assess the efficacy and selectivity of sodium channel blockers in dorsal root ganglion neurons. Rat neurons...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Chengdu Hyperway Pharmaceuticals
US Patent
Chengdu Hyperway Pharmaceuticals
US Patent
Affinity DataIC50: 7.00E+3nMAssay Description:The reagents are purchased from Sigma (St. Louis, MO) except NaOH and KOH for acid-base titration. Final concentrations of tested solutions are prepa...More data for this Ligand-Target Pair
Affinity DataIC50: 33nMAssay Description:Inhibition of human Nav1.8 expressed in HEK293 cells at -80 mV holding potential by whole-cell patch-clamp techniqueMore data for this Ligand-Target Pair
Affinity DataIC50: 86nMAssay Description:Inhibition of Nav1.8 (unknown origin)More data for this Ligand-Target Pair