BDBM16688 N-[(2S,3R)-3-amino-4-methoxy-1-phenylbutan-2-yl]-2-[(2-methoxyethyl)({[(1S,2S)-2-methylcyclopropyl]methyl})amino]-6-(N-methylpropane-2-sulfonamido)pyridine-4-carboxamide::isonicotinamide, 27

SMILES COCCN(C[C@H]1C[C@@H]1C)c1cc(cc(n1)N(C)S(=O)(=O)C(C)C)C(=O)N[C@@H](Cc1ccccc1)[C@@H](N)COC

InChI Key InChIKey=MFHZKDPQWMOWSP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 16688   

TargetBeta-secretase 1(Human)
Merck Research Laboratories

LigandPNGBDBM16688(N-[(2S,3R)-3-amino-4-methoxy-1-phenylbutan-2-yl]-2...)
Affinity DataIC50: 6nMT: 2°CAssay Description:HEK293T cells were stably transfected with APP_NFEV. One day after plating, the cells were treated for 20-24 h with a medium containing a compound or...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2007
Entry Details Article
PubMed