PMID

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Article Title

Organization

Discovery of high affinity inhibitors of Leishmania donovani N-myristoyltransferase.

Imperial College

Discovery of pyridyl-based inhibitors of Plasmodium falciparum N-myristoyltransferase.

Imperial College

Structure-based design of potent and selective Leishmania N-myristoyltransferase inhibitors.

Imperial College

On the histone lysine methyltransferase activity of fungal metabolite chaetocin.

Imperial College

Discovery of novel and ligand-efficient inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferase.

Imperial College

Dopamine D3 receptor antagonists: the quest for a potentially selective PET ligand. Part 3: Radiosynthesis and in vivo studies.

Imperial College

Design and synthesis of inhibitors of Plasmodium falciparum N-myristoyltransferase, a promising target for antimalarial drug discovery.

Imperial College

Arylstibonic acids are potent and isoform-selective inhibitors of Cdc25a and Cdc25b phosphatases.

Imperial College

Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets.

Imperial College

Discovery of Plasmodium vivax N-myristoyltransferase inhibitors: screening, synthesis, and structural characterization of their binding mode.

Imperial College

Resisting degradation by human elastase: commonality of design features shared by 'canonical' plant and bacterial macrocyclic protease inhibitor scaffolds.

Imperial College

A novel pyrazolo[1,5-a]pyrimidine is a potent inhibitor of cyclin-dependent protein kinases 1, 2, and 9, which demonstrates antitumor effects in human tumor xenografts following oral administration.

Imperial College

Development of a new epidermal growth factor receptor positron emission tomography imaging agent based on the 3-cyanoquinoline core: synthesis and biological evaluation.

Imperial College

Potent inhibitors of beta-tryptase and human leukocyte elastase based on the MCoTI-II scaffold.

Imperial College

Design, synthesis, and biological characterization of a caspase 3/7 selective isatin labeled with 2-[18F]fluoroethylazide.

Imperial College

Identification of anesthetic binding sites on human serum albumin using a novel etomidate photolabel.

Imperial College

Pyrazino[1,2-a]indole-1,4-diones, simple analogues of gliotoxin, as selective inhibitors of geranylgeranyltransferase I.

Imperial College

Novel inhibitors of carboxypeptidase G2 (CPG2): potential use in antibody-directed enzyme prodrug therapy.

Imperial College

Thienopyrimidinone Based Sirtuin-2 (SIRT2)-Selective Inhibitors Bind in the Ligand Induced Selectivity Pocket.

Imperial College

Design and synthesis of high affinity inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferases directed by ligand efficiency dependent lipophilicity (LELP).

Imperial College

Design of symmetrical and nonsymmetrical

Imperial College

Building bridges for highly selective, potent and stable oxytocin and vasopressin analogs.

Imperial College

Long chain base sphingosine kinase inhibitors

University of Virginia Patent Foundation