PMID

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Discovery of a 1,2-bis(3-indolyl)ethane that selectively inhibits the pyruvate kinase of methicillin-resistant Staphylococcus aureus over human isoforms.

University of British Columbia

Use of adenine nucleotide derivatives to assess the potential of exo-active-site-directed reagents as species- or isozyme-specific enzyme inactivators. 2. Isozyme-specific inactivation of a mammalian enzyme and its significance in the possible design of fetal isozyme targeted antineoplastic agents.

TBA

Species- or isozyme-specific enzyme inhibitors. 9. Selective effects in inhibitions of rat pyruvate kinase isozymes by adenosine 5'-diphosphate derivatives.

TBA

Tuning liver pyruvate kinase activity up or down with a new class of allosteric modulators.

University of Gothenburg

Anthraquinone derivatives as ADP-competitive inhibitors of liver pyruvate kinase.

University of Gothenburg

Tumor pyruvate kinase M2 modulators: a comprehensive account of activators and inhibitors as anticancer agents.

National Institute of Pharmaceutical Education and Research Ahmedabad

Discovery of novel naphthoquinone derivatives as inhibitors of the tumor cell specific M2 isoform of pyruvate kinase.

Peking University Health Science Center