PMID

Data

Article Title

Organization

Recent Update on Human Lactate Dehydrogenase Enzyme 5 (hLDH5) Inhibitors: A Promising Approach for Cancer Chemotherapy.

National Cancer Institute-Cro

Identification of N-acylhydrazone derivatives as novel lactate dehydrogenase A inhibitors.

University of Bologna

An update on therapeutic opportunities offered by cancer glycolytic metabolism.

University of Pisa

Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase.

Genentech

Identification of substituted 3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase.

Genentech

Identification of 3,6-disubstituted dihydropyrones as inhibitors of human lactate dehydrogenase.

Genentech

Identification of 2-amino-5-aryl-pyrazines as inhibitors of human lactate dehydrogenase.

Genentech

Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase.

Genentech

Fragment growing and linking lead to novel nanomolar lactate dehydrogenase inhibitors.

Ariad Pharmaceuticals

CNAD: a potent and specific inhibitor of alcohol dehydrogenase.

University of Rochester Medical Center

Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells.

Universita` Di Pisa

Discovery of the First Lactate Dehydrogenase Proteolysis Targeting Chimera Degrader for the Treatment of Pancreatic Cancer.

Icahn School of Medicine At Mount Sinai

Structure-based optimization of hydroxylactam as potent, cell-active inhibitors of lactate dehydrogenase.

Genentech

New salicylic acid derivatives, double inhibitors of glycolate oxidase and lactate dehydrogenase, as effective agents decreasing oxalate production.

Universidad De Granada

Discovery of novel human lactate dehydrogenase inhibitors: Structure-based virtual screening studies and biological assessment.

Sapienza University of Rome

Designed β-Hairpins Inhibit LDH5 Oligomerization and Enzymatic Activity.

Queensland University of Technology

Cannabichromene and Δ

The University of Sydney

Dual Glycolate Oxidase/Lactate Dehydrogenase A Inhibitors for Primary Hyperoxaluria.

Chinook Therapeutics

Optimization of ether and aniline based inhibitors of lactate dehydrogenase.

Vanderbilt University

Development of dual inhibitors targeting pyruvate dehydrogenase kinases and human lactate dehydrogenase A: High-throughput virtual screening, synthesis and biological validation.

Chongqing University

Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties.

National Institutes of Health

Identification of human lactate dehydrogenase A inhibitors with anti-osteosarcoma activity through cell-based phenotypic screening.

Jilin University China-Japan Union Hospital

Discovery of 2-((3-cyanopyridin-2-yl)thio)acetamides as human lactate dehydrogenase A inhibitors to reduce the growth of MG-63 osteosarcoma cells: Virtual screening and biological validation.

Heilongjiang Province Hospital

Discovery of human lactate dehydrogenase 5 inhibitors (hLDH5) with anti-lung cancer activity through an in silico method and biological validation.

The 5Th Affiliated Hospital of Shenzhen University Health Science Center

Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice.

Genentech

Interrogating the Lactate Dehydrogenase Tetramerization Site Using (Stapled) Peptides.

University of Louvain

Development of novel human lactate dehydrogenase A inhibitors: High-throughput screening, synthesis, and biological evaluations.

Hubei University of Medicine

1-(2-Hydroxybenzoyl)-thiosemicarbazides are promising antimicrobial agents targeting d-alanine-d-alanine ligase in bacterio.

University of Louvain

Inhibition of 3-phosphoglycerate dehydrogenase (PHGDH) by indole amides abrogates de novo serine synthesis in cancer cells.

Meyer Cancer Center

Selective inhibitors of human lactate dehydrogenases and lactate dehydrogenase from the malarial parasite Plasmodium falciparum.

University of New Mexico School of Medicine

Identification of a potent inhibitor targeting human lactate dehydrogenase A and its metabolic modulation for cancer cell line.

Chongqing University

Thiazole Derivatives as Inhibitors for the Treatment of Cancer Cells Resistant.

Usona Institute

Constituents of Polygala flavescens ssp. flavescens and Their Activity as Inhibitors of Human Lactate Dehydrogenase.

University of Pisa

Computer-aided discovery and biological characterization of human lactate dehydrogenase 5 inhibitors with anti-osteosarcoma activity.

Capital Medical University

Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH).

National Center For Advancing Translational Sciences

L,2-dihydro-3H-pyrazolo[3,4-D]pyrimidin-3-one analogs

Recurium Ip Holdings

Methods for treating ulcerative colitis using 3-((1R,3s,5S)-3-((7-((5-methyl-1H-pyrazol-3-yl)amino)-1,6-naphthyridin-5-yl)amino)-8-azabicyclo[3.2.1]octan-8-yl)propanenitrile

Theravance Biopharma R&D Ip

Bicyclic pyridone lactams and methods of use thereof

Genentech

Cardiac glycoside analogs and their use in methods for inhibition of viral infection

The John Hopkins University

Substituted N-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs as tyrosine receptor kinase BTK inhibitors

University of Utah Research Foundation

Synthesis and biological evaluation of some new N(4)-substituted isatin-3-thiosemicarbazones.

Bahauddin Zakariya University

Novel behavior of O-methylated beta-cyclodextrins in inclusion of meso-tetraarylporphyrins.

Doshisha University