Compile Data Set for Download or QSAR
Report error Found 34 Enz. Inhib. hit(s) with all data for entry = 50014135
TargetL-lactate dehydrogenase A chain(Human)
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50572932(CHEMBL4850573)
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of recombinant human LDHA expressed in BL21 gold (DE3) using sodium pyruvate as substrate preincubated for 10 mins followed by sodium pyru...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetL-lactate dehydrogenase A chain(Mouse)
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50250656(CHEMBL4081890 | US11247971, Cmpd ID 276)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of recombinant mouse LDHA expressed in BL21 gold (DE3) using sodium pyruvate as substrate preincubated for 10 mins followed by sodium pyru...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50572931(CHEMBL4855986)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of recombinant human LDHA expressed in BL21 gold (DE3) using sodium pyruvate as substrate preincubated for 10 mins followed by sodium pyru...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetL-lactate dehydrogenase A chain(Mouse)
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50572933(CHEMBL4861379)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of recombinant mouse LDHA expressed in BL21 gold (DE3) using sodium pyruvate as substrate preincubated for 10 mins followed by sodium pyru...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetL-lactate dehydrogenase A chain(Mouse)
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50572931(CHEMBL4855986)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of recombinant mouse LDHA expressed in BL21 gold (DE3) using sodium pyruvate as substrate preincubated for 10 mins followed by sodium pyru...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50572934(CHEMBL4847068)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of recombinant human LDHA expressed in BL21 gold (DE3) using sodium pyruvate as substrate preincubated for 10 mins followed by sodium pyru...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50572933(CHEMBL4861379)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of recombinant human LDHA expressed in BL21 gold (DE3) using sodium pyruvate as substrate preincubated for 10 mins followed by sodium pyru...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetL-lactate dehydrogenase A chain(Mouse)
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50572930(CHEMBL4873879)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of recombinant mouse LDHA expressed in BL21 gold (DE3) using sodium pyruvate as substrate preincubated for 10 mins followed by sodium pyru...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetL-lactate dehydrogenase A chain(Mouse)
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50572934(CHEMBL4847068)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of recombinant mouse LDHA expressed in BL21 gold (DE3) using sodium pyruvate as substrate preincubated for 10 mins followed by sodium pyru...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50572930(CHEMBL4873879)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of recombinant human LDHA expressed in BL21 gold (DE3) using sodium pyruvate as substrate preincubated for 10 mins followed by sodium pyru...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetL-lactate dehydrogenase A chain(Mouse)
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50572932(CHEMBL4850573)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of recombinant mouse LDHA expressed in BL21 gold (DE3) using sodium pyruvate as substrate preincubated for 10 mins followed by sodium pyru...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50572929(CHEMBL4864519)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of recombinant human LDHA expressed in BL21 gold (DE3) using sodium pyruvate as substrate preincubated for 10 mins followed by sodium pyru...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetL-lactate dehydrogenase A chain(Mouse)
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50572929(CHEMBL4864519)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of recombinant mouse LDHA expressed in BL21 gold (DE3) using sodium pyruvate as substrate preincubated for 10 mins followed by sodium pyru...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target2-Hydroxyacid oxidase 1(Human)
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50572931(CHEMBL4855986)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of recombinant human GOX expressed in Escherichia coli C41 (DE3) using glycolate as substrate preincubated for 10 mins followed by substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target2-Hydroxyacid oxidase 1(Human)
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50572933(CHEMBL4861379)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of recombinant human GOX expressed in Escherichia coli C41 (DE3) using glycolate as substrate preincubated for 10 mins followed by substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target2-Hydroxyacid oxidase 1(Human)
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50572932(CHEMBL4850573)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of recombinant human GOX expressed in Escherichia coli C41 (DE3) using glycolate as substrate preincubated for 10 mins followed by substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50103568(CHEMBL3335794)
Affinity DataIC50: 2.60nMAssay Description:Competitive inhibition of recombinant human LDHA in the presence of NADH by resazurin dye reduction methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target2-Hydroxyacid oxidase 1(Human)
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50572934(CHEMBL4847068)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of recombinant human GOX expressed in Escherichia coli C41 (DE3) using glycolate as substrate preincubated for 10 mins followed by substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target2-Hydroxyacid oxidase 1(Human)
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50572929(CHEMBL4864519)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of recombinant human GOX expressed in Escherichia coli C41 (DE3) using glycolate as substrate preincubated for 10 mins followed by substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target2-Hydroxyacid oxidase 1(Human)
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50572928(CHEMBL4857427)
Affinity DataIC50: 6.70nMAssay Description:Inhibition of recombinant human GOX expressed in Escherichia coli C41 (DE3) using glycolate as substrate preincubated for 10 mins followed by substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target2-Hydroxyacid oxidase 1(Mouse)
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50572929(CHEMBL4864519)
Affinity DataIC50: 7.70nMAssay Description:Inhibition of recombinant mouse GOX expressed in Escherichia coli C41 (DE3) using glycolate as substrate preincubated for 10 mins followed by substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target2-Hydroxyacid oxidase 1(Human)
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50572930(CHEMBL4873879)
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant human GOX expressed in Escherichia coli C41 (DE3) using glycolate as substrate preincubated for 10 mins followed by substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target2-Hydroxyacid oxidase 1(Mouse)
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50572928(CHEMBL4857427)
Affinity DataIC50: 15nMAssay Description:Inhibition of recombinant mouse GOX expressed in Escherichia coli C41 (DE3) using glycolate as substrate preincubated for 10 mins followed by substra...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50250656(CHEMBL4081890 | US11247971, Cmpd ID 276)
Affinity DataIC50: 32nMAssay Description:Inhibition of recombinant human LDHA expressed in BL21 gold (DE3) using sodium pyruvate as substrate preincubated for 10 mins followed by sodium pyru...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHydroxyacid oxidase 1(Pig)
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50572935(CHEMBL4848350)
Affinity DataIC50: 87nMAssay Description:Inhibition of pig HAO1 in presence of NADH by spectrometry analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetL-lactate dehydrogenase A chain(Mouse)
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50572929(CHEMBL4864519)
Affinity DataIC50: 136nMAssay Description:Inhibition of LDHA in wild type CD1 mouse primary hepatocyte assessed as inhibition of lactate production using pyruvate as substrate measured after ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetL-lactate dehydrogenase A chain(Mouse)
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50572931(CHEMBL4855986)
Affinity DataIC50: 143nMAssay Description:Inhibition of LDHA in wild type CD1 mouse primary hepatocyte assessed as inhibition of lactate production using pyruvate as substrate measured after ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetL-lactate dehydrogenase A chain(Mouse)
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50572934(CHEMBL4847068)
Affinity DataIC50: 170nMAssay Description:Inhibition of LDHA in wild type CD1 mouse primary hepatocyte assessed as inhibition of lactate production using pyruvate as substrate measured after ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetL-lactate dehydrogenase A chain(Mouse)
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50572932(CHEMBL4850573)
Affinity DataIC50: 198nMAssay Description:Inhibition of LDHA in wild type CD1 mouse primary hepatocyte assessed as inhibition of lactate production using pyruvate as substrate measured after ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetL-lactate dehydrogenase A chain(Mouse)
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50572933(CHEMBL4861379)
Affinity DataIC50: 230nMAssay Description:Inhibition of LDHA in wild type CD1 mouse primary hepatocyte assessed as inhibition of lactate production using pyruvate as substrate measured after ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM86137(LDHA Inhibitor, 33)
Affinity DataIC50: 500nMAssay Description:Inhibition of recombinant human LDHA expressed in BL21 gold (DE3) using sodium pyruvate as substrate preincubated for 10 mins followed by sodium pyru...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetL-lactate dehydrogenase A chain(Mouse)
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50572930(CHEMBL4873879)
Affinity DataIC50: 732nMAssay Description:Inhibition of LDHA in wild type CD1 mouse primary hepatocyte assessed as inhibition of lactate production using pyruvate as substrate measured after ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target2-Hydroxyacid oxidase 1(Human)
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50463046(CHEMBL1229989)
Affinity DataKi:  15nMAssay Description:Inhibition of human glycolate oxidase expressed in Escherichia coli using glycolate as substrate by DCIP dye based spectrophotometry analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target2-Hydroxyacid oxidase 1(Mouse)
Chinook Therapeutics

Curated by ChEMBL
LigandPNGBDBM50463047(CHEMBL1794748)
Affinity DataKi:  4.50E+3nMAssay Description:Non competitive inhibition of mouse glycolate oxidase in hyperoxaluric-Agxt knockdown mouse primary hepatocyte assessed as reduction in oxalate produ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed