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Discovery of novel Trypanosoma brucei phosphodiesterase B1 inhibitors by virtual screening against the unliganded TbrPDEB1 crystal structure.

Vu University Amsterdam

Structure-based design, synthesis and structure-activity relationships of dibenzosuberyl- and benzoate-substituted tropines as ligands for acetylcholine-binding protein.

Vu University Amsterdam

Molecular determinants of ligand binding modes in the histamine H(4) receptor: linking ligand-based three-dimensional quantitative structure-activity relationship (3D-QSAR) models to in silico guided receptor mutagenesis studies.

Vu University Amsterdam

Fragment library screening reveals remarkable similarities between the G protein-coupled receptor histamine H4 and the ion channel serotonin 5-HT3A.

Vu University Amsterdam

Triazole ligands reveal distinct molecular features that induce histamine H4 receptor affinity and subtly govern H4/H3 subtype selectivity.

Vu University Amsterdam

Surface plasmon resonance biosensor based fragment screening using acetylcholine binding protein identifies ligand efficiency hot spots (LE hot spots) by deconstruction of nicotinic acetylcholine receptora7 ligands.

Vu University Amsterdam

Clobenpropit analogs as dual activity ligands for the histamine H3 and H4 receptors: synthesis, pharmacological evaluation, and cross-target QSAR studies.

Vu University Amsterdam

Exploring a pocket for polycycloaliphatic groups in the CXCR3 receptor with the aid of a modular synthetic strategy.

Vu University Amsterdam

CXCR3 antagonists: quaternary ammonium salts equipped with biphenyl- and polycycloaliphatic-anchors.

Vu University Amsterdam

Chemical subtleties in small-molecule modulation of peptide receptor function: the case of CXCR3 biaryl-type ligands.

Vu University Amsterdam

Design, synthesis, and structure-activity relationships of highly potent 5-HT3 receptor ligands.

Vu University Amsterdam

Catechol pyrazolinones as trypanocidals: fragment-based design, synthesis, and pharmacological evaluation of nanomolar inhibitors of trypanosomal phosphodiesterase B1.

Vu University Amsterdam

Synthesis, modeling and functional activity of substituted styrene-amides as small-molecule CXCR7 agonists.

Vu University Amsterdam

Fragment based lead discovery of small molecule inhibitors for the EPHA4 receptor tyrosine kinase.

Vu University Amsterdam

Crystal structure-based virtual screening for fragment-like ligands of the human histamine H(1) receptor.

Vu University Amsterdam

Acetylcholine binding protein (AChBP) as template for hierarchical in silico screening procedures to identify structurally novel ligands for the nicotinic receptors.

Vu University Amsterdam

Selectivity of TMC207 towards mycobacterial ATP synthase compared with that towards the eukaryotic homologue.

Vu University Amsterdam

Targeting the interaction of β-catenin and TCF/LEF transcription factors to inhibit oncogenic Wnt signaling.

Vu University Amsterdam

Route to Prolonged Residence Time at the Histamine H

Vu University Amsterdam

KLIFS: a knowledge-based structural database to navigate kinase-ligand interaction space.

Vu University Amsterdam

Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B2) for the treatment of congestive heart failure and myocardial fibrosis.

Saarland University