PMID

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Article Title

Organization

Leupeptazin, a highly modified tripeptide isolated from cultures of a Streptomyces sp. inhibits cathepsin K.

University of British Columbia

Affinity Crystallography: A New Approach to Extracting High-Affinity Enzyme Inhibitors from Natural Extracts.

University of British Columbia

In silico to in vitro screening of hydroxypyridinones as acetylcholinesterase inhibitors.

University of British Columbia

Discovery of 1H-indole-2-carboxamides as novel inhibitors of the androgen receptor binding function 3 (BF3).

University of British Columbia

Discovery of a 1,2-bis(3-indolyl)ethane that selectively inhibits the pyruvate kinase of methicillin-resistant Staphylococcus aureus over human isoforms.

University of British Columbia

Phosphinic acid-based inhibitors of tubulin polyglutamylases.

University of British Columbia

Modular, efficient synthesis of asymmetrically substituted piperazine scaffolds as potent calcium channel blockers.

University of British Columbia

Targeting the binding function 3 (BF3) site of the androgen receptor through virtual screening. 2. development of 2-((2-phenoxyethyl) thio)-1H-benzimidazole derivatives.

University of British Columbia

An updated steroid benchmark set and its application in the discovery of novel nanomolar ligands of sex hormone-binding globulin.

University of British Columbia

Halicloic acids A and B isolated from the marine sponge Haliclona sp. collected in the Philippines inhibit indoleamine 2,3-dioxygenase.

University of British Columbia

Rapid assembly of a library of lipophilic iminosugars via the thiol-ene reaction yields promising pharmacological chaperones for the treatment of Gaucher disease.

University of British Columbia

Progressive docking: a hybrid QSAR/docking approach for accelerating in silico high throughput screening.

University of British Columbia

First enantioselective syntheses of the dopamine D1 and D2 receptor modulators, (+)- and (-)-govadine.

University of British Columbia

Targeting the binding function 3 (BF3) site of the human androgen receptor through virtual screening.

University of British Columbia

Inhibitors of androgen receptor activation function-2 (AF2) site identified through virtual screening.

University of British Columbia

6''-Azido-6''-deoxy-UDP-N-acetylglucosamine as a glycosyltransferase substrate.

University of British Columbia

Synthesis of phosphatidylinositol 3-kinase (PI3K) inhibitory analogues of the sponge meroterpenoid liphagal.

University of British Columbia

Indoleamine 2,3-dioxygenase inhibitors from the Northeastern Pacific Marine Hydroid Garveia annulata.

University of British Columbia

Meroterpenoid MAPKAP (MK2) inhibitors isolated from the indonesian marine sponge Acanthodendrilla sp.

University of British Columbia

Thorectidiol A Isolated from the Marine Sponge

University of British Columbia

A guanidinium group is an effective mimic of the tertiary carbocation formed by isopentenyl diphosphate isomerase.

University of British Columbia

Successful in silico discovery of novel nonsteroidal ligands for human sex hormone binding globulin.

University of British Columbia

Development of 2-(5,6,7-Trifluoro-1

University of British Columbia

A guanidinium-based inhibitor of a type I isopentenyl diphosphate isomerase.

University of British Columbia

Towards the PET radiotracer for p75 neurotrophin receptor: [(11)C]LM11A-24 shows biological activity in vitro, but unfavorable ex vivo and in vivo profile.

University of British Columbia

Computer-aided drug discovery of Myc-Max inhibitors as potential therapeutics for prostate cancer.

University of British Columbia

Discovery of small-molecule inhibitors selectively targeting the DNA-binding domain of the human androgen receptor.

University of British Columbia

Scalarane-based sesterterpenoid RCE-protease inhibitors isolated from the Indonesian marine sponge Carteriospongia foliascens.

University of British Columbia

Thienopyrimidones

Boehringer Ingelheim International

Substituted indazoles, methods for the production thereof, pharmaceutical preparations that contain said new substituted indazoles, and use of said new substituted indazoles to produce drugs

Bayer Pharma Aktiengesellschaft

Kinase inhibitors

Topivert Pharma

ASK1 inhibitor compounds and uses thereof

Seal Rock Therapeutics

Differences in agonist/antagonist binding affinity and receptor transduction using recombinant human gamma-aminobutyric acid type A receptors.

Merck Sharp and Dohme Research Laboratories