51 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
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Discovery and pharmacological evaluation of a novel series of adamantyl cyanoguanidines as P2X
The University of Sydney
Flexible analogues of WAY-267,464: Synthesis and pharmacology at the human oxytocin and vasopressin 1a receptors.
The University of Sydney
Cyclic Peptides Incorporating Phosphotyrosine Mimetics as Potent and Specific Inhibitors of the Grb7 Breast Cancer Target.
The University of Sydney
Structure-activity relationship studies of SEN12333 analogues: determination of the optimal requirements for binding affinities ata7 nAChRs through incorporation of known structural motifs.
The University of Sydney
Investigations of amide bond variation and biaryl modification in analogues ofa7 nAChR agonist SEN12333.
The University of Sydney
Synthesis of gallinamide A analogues as potent falcipain inhibitors and antimalarials.
The University of Sydney
Structure-activity relationships of N-substituted 4-(trifluoromethoxy)benzamidines with affinity for GluN2B-containing NMDA receptors.
The University of Sydney
N-substituted 8-aminopentacyclo[5.4.0.0(2,6).0(3,10).0(5,9)]undecanes ass receptor ligands with potential neuroprotective effects.
The University of Sydney
The development of CNS-active LRRK2 inhibitors using property-directed optimisation.
The University of Sydney
The discovery of novel isoflavone pan peroxisome proliferator-activated receptor agonists.
The University of Sydney
Design, Synthesis, and Pharmacological Evaluation of Fluorescent and Biotinylated Antagonists ofρ1 GABAC Receptors.
The University of Sydney
Identification of selective inhibitors of indoleamine 2,3-dioxygenase 2.
The University of Sydney
As(1) receptor pharmacophore derived from a series of N-substituted 4-azahexacyclo[5.4.1.0(2,6).0(3,10).0(5,9).0(8,11)]dodecan-3-ols (AHDs).
The University of Sydney
Exploration of ring size in a series of cyclic vicinal diamines withs1 receptor affinity.
The University of Sydney
7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (s2) receptor ligands.
The University of Sydney
Consequences of linker length alteration of thea7 nicotinic acetylcholine receptor (nAChR) agonist, SEN12333.
The University of Sydney
Enantioselective actions of 4-amino-3-hydroxybutanoic acid and (3-amino-2-hydroxypropyl)methylphosphinic acid at recombinant GABA(C) receptors.
The University of Sydney
Chiral derivatives of 2-cyclohexylideneperhydro-4,7-methanoindenes, a novel class of nonsteroidal androgen receptor ligand: synthesis, X-ray analysis, and biological activity.
The University of Sydney
Aminomethyl-2,6-difluorophenols as a novel class of increased lipophilicity GABA(C) receptor antagonists.
The University of Sydney
Design and synthesis of novel inhibitors of human kynurenine aminotransferase-I.
The University of Sydney
Synthesis and in vivo evaluation of [18F]N-(2-benzofuranylmethyl)-N'-[4-(2-fluoroethoxy)benzyl]piperazine, a novels1 receptor PET imaging agent.
The University of Sydney
Effects of linker elongation in a series of N-(2-benzofuranylmethyl)-N'-(methoxyphenylalkyl)piperazines¿? receptor ligands.
The University of Sydney
N-Arylalkyl-2-azaadamantanes as cage-expanded polycarbocyclic sigma (s) receptor ligands.
The University of Sydney
Molecular hybridization of 4-azahexacyclo[5.4.1.0(2,6).0(3,10).0(5,9).0(8,11)]dodecane-3-ol with sigma (s) receptor ligands modulates off-target activity and subtype selectivity.
The University of Sydney
Trishomocubane as a scaffold for the development of selective dopamine transporter (DAT) ligands.
The University of Sydney
Synthesis, antifungal, haemolytic and cytotoxic activities of a series of bis(alkylpyridinium)alkanes.
The University of Sydney
7-Hydroxy-benzopyran-4-one derivatives: a novel pharmacophore of peroxisome proliferator-activated receptor alpha and -gamma (PPARalpha and gamma) dual agonists.
The University of Sydney
Recent Scaffold Hopping Applications in Central Nervous System Drug Discovery.
The University of Sydney
Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L.
The University of Sydney
Correlation of antifungal activity with fungal phospholipase inhibition using a series of bisquaternary ammonium salts.
The University of Sydney
Potent Cyclic Peptide Inhibitors of FXIIa Discovered by mRNA Display with Genetic Code Reprogramming.
The University of Sydney
The discovery of a potent and selective pyrazolo-[2,3-e]-[1,2,4]-triazine cannabinoid type 2 receptor agonist.
The University of Sydney
Nonclassical Phenyl Bioisosteres as Effective Replacements in a Series of Novel Open-Source Antimalarials.
The University of Sydney
Immobilized Metal Affinity Chromatography as a Drug Discovery Platform for Metalloenzyme Inhibitors.
The University of Sydney
Exploring hydroxamic acid inhibitors of HDAC1 and HDAC2 using small molecule tools and molecular or homology modelling.
The University of Sydney
Falcipain Inhibitors Based on the Natural Product Gallinamide A Are Potent in Vitro and in Vivo Antimalarials.
The University of Sydney
GABA allosteric modulators: An overview of recent developments in non-benzodiazepine modulators.
The University of Sydney
Identification of dual PPARα/γ agonists and their effects on lipid metabolism.
The University of Sydney
Synthesis and biological evaluation of flavan-3-ol derivatives as positive modulators of GABAA receptors.
The University of Sydney
Conformationally rigid derivatives of WAY-267,464: Synthesis and pharmacology at the human oxytocin and vasopressin-1a receptors.
The University of Sydney
Investigation of pyrazolo-sulfonamides as putative small molecule oxytocin receptor agonists.
The University of Sydney
A novel class of thiosemicarbazones show multi-functional activity for the treatment of Alzheimer's disease.
The University of Sydney
Pharmacological evaluation of a novel series of urea, thiourea and guanidine derivatives as P2X
The University of Sydney
