PMID

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Fine tuning of agonistic/antagonistic activity for vitamin D receptor by 22-alkyl chain length of ligands: 22S-Hexyl compound unexpectedly restored agonistic activity.

Showa Pharmaceutical University

A mixed population of antagonist and agonist binding conformers in a single crystal explains partial agonism against vitamin D receptor: active vitamin D analogues with 22R-alkyl group.

Showa Pharmaceutical University

Design and characterization of a selenium-containing inhibitor of activated thrombin-activatable fibrinolysis inhibitor (TAFIa), a zinc-containing metalloprotease.

Showa Pharmaceutical University

Butyl pocket formation in the vitamin D receptor strongly affects the agonistic or antagonistic behavior of ligands.

Showa Pharmaceutical University

A new class of vitamin D analogues that induce structural rearrangement of the ligand-binding pocket of the receptor.

Showa Pharmaceutical University

Zamamiphidins B and C, Manzamine-Related Alkaloids from an

Showa Pharmaceutical University

Design and synthesis of selective CYP1B1 inhibitor via dearomatization of α-naphthoflavone.

Showa Pharmaceutical University

Identification of the Histidine Residue in Vitamin D Receptor That Covalently Binds to Electrophilic Ligands.

Showa Pharmaceutical University

Structural basis for the selective inhibition of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) by a selenium-containing inhibitor with chloro-aminopyridine as a basic group.

Showa Pharmaceutical University

Vitamin D Analogues with a p-Hydroxyphenyl Group at the C25 Position: Crystal Structure of Vitamin D Receptor Ligand-Binding Domain Complexed with the Ligand Explains the Mechanism Underlying Full Antagonistic Action.

Showa Pharmaceutical University