PMID

Data

Article Title

Organization

A triple exon-skipping luciferase reporter assay identifies a new CLK inhibitor pharmacophore.

Sri International

17-Desoxy estrogen analogues.

Sri International

Diamino-1,2,4-triazole derivatives are selective inhibitors of TYK2 and JAK1 over JAK2 and JAK3.

Sri International

Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 4. Effect of various side-chain substituents on therapeutic activity against anticholinesterase intoxication.

Sri International

Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 2. Preparation and in vitro and in vivo evaluation of 1-(alkoxymethyl)-2-[(hydroxyimino)methyl]-3-methylimida zolium halides for reactivation of organophosphorus-inhibited acetylcholinesterases.

Sri International

Effects of addition of a 2-methyl group to ethyl nipecotates (beta-meperidines) on receptor affinities and opiate agonist/antagonist activities.

Sri International

Synthesis and biological evaluation of 8-deazahomofolic acid and its tetrahydro derivative.

Sri International

The design and synthesis of a novel quinolizidine template for potent opioid and opioid receptor-like (ORL1, NOP) receptor ligands.

Sri International

Novela3ß4 nicotinic acetylcholine receptor-selective ligands. Discovery, structure-activity studies, and pharmacological evaluation.

Sri International

A novel series of piperidin-4-yl-1,3-dihydroindol-2-ones as agonist and antagonist ligands at the nociceptin receptor.

Sri International

Conformational effects on retinoid receptor selectivity. 1. Effect of 9-double bond geometry on retinoid X receptor activity.

Sri International

Synthesis and antitumor activity of 10-propargyl-10-deazaaminopterin.

Sri International

Conformational effects on retinoid receptor selectivity. 2. Effects of retinoid bridging group on retinoid X receptor activity and selectivity.

Sri International

Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 3. Synthesis and evaluation of (alkenyloxy)-, (alkynyloxy)-, and (aralkyloxy)methyl quaternarized 2-[(hydroxyimino)methyl]-1-alkylimidazolium halides as reactivators and therapy for soman intoxication.

Sri International

Synthesis and antifolate properties of 10-alkyl-5,10-dideaza analogues of methotrexate and tetrahydrofolic acid.

Sri International

Synthesis and antifolate properties of 9-alkyl-10-deazaminopterins.

Sri International

Synthesis and antifolate properties of 5,10-ethano-5,10-dideazaaminopterin.

Sri International

Pyrido-, pyrazo- and pyrimido-pyrimidine derivatives as mTOR inhibitors

Kudos Pharmaceuticals

Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells.

Johnson & Johnson Pharmaceutical